公开(公告)号：US11810772B2

公开(公告)日：2023-11-07

申请号：US17731684

申请日：2022-04-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea Guna

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/004 ,  H01J49/427 ,  H01J49/4225 ,  H01J49/4265

Abstract: In one aspect, a method of processing ions in a mass spectrometer is disclosed, which comprises trapping a plurality of ions having different mass-to-charge (m/z) ratios in a collision cell, releasing said ions from the collision cell in a descending order in m/z ratio, and receiving the ions in a mass analyzer having a plurality of rods to at least one of which an RF voltage is applied, where the RF voltage is varied from a first value to a lower second value as the released ions are received by the mass analyzer.

公开(公告)号：US20220254618A1

公开(公告)日：2022-08-11

申请号：US17731684

申请日：2022-04-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea Guna

IPC: H01J49/00 ,  H01J49/42

Abstract: In one aspect, a method of processing ions in a mass spectrometer is disclosed, which comprises trapping a plurality of ions having different mass-to-charge (m/z) ratios in a collision cell, releasing said ions from the collision cell in a descending order in m/z ratio, and receiving the ions in a mass analyzer having a plurality of rods to at least one of which an RF voltage is applied, where the RF voltage is varied from a first value to a lower second value as the released ions are received by the mass analyzer.

公开(公告)号：US20150041639A1

公开(公告)日：2015-02-12

申请号：US14369601

申请日：2012-12-04

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea Guna

IPC: H01J49/42 ,  H01J49/26 ,  H01J49/06 ,  H01J49/00

CPC classification number: H01J49/4265 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/061 ,  H01J49/26

Abstract: A method is provided comprising accumulating ions in a first ion trap at a first time; transmitting a first plurality of ions out of the first ion trap through a timed-ion selector; applying a pulsed DC voltage to the timed-ion selector; transmitting the first portion of selected ions into a second ion trap at a second time; retaining a second plurality of ions in the first ion trap at the second time; transmitting the first portion of selected ions out of the second ion trap at a third time; transmitting the second plurality of ions out of the first ion trap through a timed-ion selector; applying a pulsed DC voltage to the timed-ion selector transmitting a second portion of selected ions into the second ion trap at a fourth time; and transmitting the second portion of selected ions out of the second trap.

Abstract translation: 提供了一种方法，包括在第一时间将离子累积在第一离子阱中; 通过定时离子选择器将第一多个离子从第一离子阱中传出; 将脉冲DC电压施加到定时离子选择器; 在第二时间将选定离子的第一部分传输到第二离子阱中; 在第二时间将第二多个离子保留在第一离子阱中; 在第三时间将选定离子的第一部分从第二离子阱中传出; 通过定时离子选择器将第二多个离子从第一离子阱中传出; 将脉冲DC电压施加到所述定时离子选择器，其在第四时间将选择的离子的第二部分传输到所述第二离子阱中; 以及将所述第二部分所选择的离子从所述第二陷阱中传出。

公开(公告)号：US11562895B2

公开(公告)日：2023-01-24

申请号：US17274105

申请日：2019-09-04

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Mircea Guna

IPC: H01J49/42 ,  H01J49/04

Abstract: A method of processing ions in a mass spectrometer comprises introducing one or more precursor ions into a collision cell to fragment at least a portion of said ions, where the collision cell is configured to confine ions having m/z ratios above a selected threshold (i.e., high m/z ions). The ions are released from the collision cell and introduced into a downstream analyzer ion trap to radially confine high m/z ions. The collision cell and the analyzer ion trap are configured to confine ions having m/z ratios below said selected threshold (i.e., low m/z ions). Ions are introduced into the collision cell and undergo fragmentation. The fragment ions are released from the collision cell and introduced into the analyzer ion trap, thus loading the analyzer ion trap with both high m/z and low m/z ions. The ions are released from the analyzer ion trap and detected by a detector.

公开(公告)号：US11348777B2

公开(公告)日：2022-05-31

申请号：US17274057

申请日：2019-09-04

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea Guna

IPC: H01J49/00 ,  H01J49/42

Abstract: In one aspect, a method of processing ions in a mass spectrometer is disclosed, which comprises trapping a plurality of ions having different mass-to-charge (m/z) ratios in a collision cell, releasing said ions from the collision cell in a descending order in m/z ratio, and receiving the ions in a mass analyzer having a plurality of rods to at least one of which an RF voltage is applied, where the RF voltage is varied from a first value to a lower second value as the released ions are received by the mass analyzer.

公开(公告)号：US20210202230A1

公开(公告)日：2021-07-01

申请号：US17274105

申请日：2019-09-04

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Mircea Guna

IPC: H01J49/42 ,  H01J49/04

Abstract: A method of processing ions in a mass spectrometer comprises introducing one or more precursor ions into a collision cell to fragment at least a portion of said ions, where the collision cell is configured to confine ions having m/z ratios above a selected threshold (i.e., high m/z ions). The ions are released from the collision cell and introduced into a downstream analyzer ion trap to radially confine high m/z ions. The collision cell and the analyzer ion trap are configured to confine ions having m/z ratios below said selected threshold (i.e., low m/z ions). Ions are introduced into the collision cell and undergo fragmentation. The fragment ions are released from the collision cell and introduced into the analyzer ion trap, thus loading the analyzer ion trap with both high m/z and low m/z ions. The ions are released from the analyzer ion trap and detected by a detector.

公开(公告)号：US20180286659A1

公开(公告)日：2018-10-04

申请号：US15763878

申请日：2016-09-23

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea Guna

IPC: H01J49/42

CPC classification number: H01J49/4225 ,  H01J49/063 ,  H01J49/4215 ,  H01J49/4255

Abstract: A linear ion trap includes a quadrupole having four substantially parallel conductive rods that are substantially coextensive in the axial direction. The rods include two diagonally arranged pairs including one continuous, rod pair and one pair of rods that are segmented such that the two segments in a rod are capacitively coupled to facilitate an RF drop when an RF signal is applied to one longer segment and capacitively provided to the other shorter segment. An RF signal is provided to the continuous rods and tire longer segment of the segmented rods.

公开(公告)号：US20180114684A1

公开(公告)日：2018-04-26

申请号：US15571301

申请日：2016-03-29

Applicant: DH Technologies Development PTE Ltd.

Inventor： Mircea Guna

IPC: H01J49/06 ,  H01J49/00 ,  H01J49/10 ,  H01J49/26

CPC classification number: H01J49/061 ,  H01J49/0027 ,  H01J49/062 ,  H01J49/067 ,  H01J49/10 ,  H01J49/24 ,  H01J49/26

Abstract: In one aspect, a mass spectrometer is disclosed, which comprises an ion source for generating ions, a chamber comprising a curtain plate providing an inlet orifice for receiving at least a portion of said generated ions, and a deflection electrode disposed upstream of said inlet orifice and positioned relative thereto so as to modulate, in response to application of different voltages thereto, a flux of said ions reaching the inlet orifice.

公开(公告)号：US09779930B2

公开(公告)日：2017-10-03

申请号：US15107177

申请日：2014-12-06

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea Guna

IPC: H01J49/42 ,  H01J49/26 ,  H01J49/28 ,  H01J49/00 ,  H01J49/02 ,  H01J49/06

CPC classification number: H01J49/4245 ,  H01J49/0031 ,  H01J49/027 ,  H01J49/063 ,  H01J49/26 ,  H01J49/282

Abstract: Systems and methods are provided for performing multiplex electrostatic linear ion trap mass spectrometry. A first beam of ions is received and the first beam is split into N beams of ions using a beam splitter. N is two or more. Ions are received from only one of the N beams of ions at each entrance aperture of N entrance apertures of an electrostatic linear ion trap (ELIT). Ions from each entrance aperture of the N entrance apertures are trapped in separate linear flight paths using the ELIT, producing N separate linear flight paths. Ion oscillations in the N separate linear flight paths are measured at substantially the same time using the ELIT. The ELIT uses two concentric mirrors with N apertures to trap ions in the N separate linear flight paths. The ELIT uses an image current detector with N apertures to the measure the ion oscillations.

公开(公告)号：US09576779B2

公开(公告)日：2017-02-21

申请号：US14369480

申请日：2012-11-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea Guna

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/10

CPC classification number: H01J49/0045 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/10

Abstract: A method of operating a tandem mass spectrometer system is disclosed including accumulating ions in an ion trap, transmitting a plurality of ions out of the ion trap into a timed-ion selector, applying a pulsed DC voltage to the timed-ion selector, the pulsed DC voltage being modulated to match an ejection time for selecting a first portion of ions from the plurality of ions, corresponding to a specific m/z window, transmitting the first portion of selected ions out of the timed-ion selector into a reaction cell, transmitting dissociation product ions and the remaining ions of the first portion of selected ions out of the reaction cell into a mass analyzer, and mass-selectively transmitting at least some of the fragment ions and the remaining ions of the first portion of selected ions out of the mass analyzer into a detector.

Abstract translation: 公开了一种操作串联质谱仪系统的方法，包括在离子阱中积聚离子，将多个离子从离子阱中传输到定时离子选择器中，将脉冲DC电压施加到定时离子选择器，脉冲 DC电压被调制以匹配喷射时间，用于从对应于特定m / z窗口的多个离子中选择离子的第一部分，将选定离子的第一部分从定时离子选择器传输到反应池中， 将离解产物离子和所选离子的第一部分的剩余离子从反应池中转移到质量分析器中，并且批量选择性地将选定离子的第一部分中的至少一些碎片离子和剩余离子从 质量分析仪成为检测器。