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公开(公告)号：US10253357B2
公开(公告)日：2019-04-09
申请号：US15306240
申请日：2015-04-24
Applicant: Diassess Inc.
Inventor： Debkishore Mitra , Ivan Krastev Dimov , John Robert Waldeisen
IPC: C12P19/34 , C12Q1/6844
Abstract: Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces an amplification reaction product if the sample contains a target nucleic acid template molecule. The reaction mix includes an enzyme for catalyzing the amplification reaction, and at least one halochromic agent. If the target nucleic acid template molecule is present, the amplification reaction changes the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating the presence of the target nucleic acid. If the target nucleic acid template molecule is not present, the amplification reaction does not generate an adequate number of protons to sufficiently change the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating that the amplification reaction product has not been produced.
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公开(公告)号：US10146909B2
公开(公告)日：2018-12-04
申请号：US15481349
申请日：2017-04-06
Applicant: Diassess Inc.
Inventor： Ivan Krastev Dimov , Frank B. Myers, III , John Robert Waldeisen , Debkishore Mitra
Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.
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公开(公告)号：US20200030798A1
公开(公告)日：2020-01-30
申请号：US16081802
申请日：2017-03-14
Applicant: Diassess Inc.
Inventor： Debkishore Mitra , Frank B. Myers, III , John Robert Waldeisen , Ivan Krastev Dimov
Abstract: Selectively vented biological assay devices and methods of performing biological assays with such devices are provided herein. Disclosed devices include a selective venting element having passively tunable porosity. The methods include controlling fluid flow within the subject devices with the selective venting element.
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公开(公告)号：US20190309356A1
公开(公告)日：2019-10-10
申请号：US16359913
申请日：2019-03-20
Applicant: Diassess Inc.
Inventor： Debkishore Mitra , Ivan Krastev Dimov , John Robert Waldeisen
IPC: C12Q1/6844
Abstract: Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces an amplification reaction product if the sample contains a target nucleic acid template molecule. The reaction mix includes an enzyme for catalyzing the amplification reaction, and at least one halochromic agent. If the target nucleic acid template molecule is present, the amplification reaction changes the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating the presence of the target nucleic acid. If the target nucleic acid template molecule is not present, the amplification reaction does not generate an adequate number of protons to sufficiently change the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating that the amplification reaction product has not been produced.
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公开(公告)号：US20190050988A1
公开(公告)日：2019-02-14
申请号：US16155829
申请日：2018-10-09
Applicant: Diassess Inc.
Inventor： Ivan Krastev Dimov , Frank B. Myers, III , John Robert Waldeisen , Debkishore Mitra
Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.
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Patent Agency Ranking
公开(公告)号：US20190083975A1
公开(公告)日：2019-03-21
申请号：US16081793
申请日：2017-03-14
Applicant: Diassess Inc.
Inventor： Debkishore Mitra , Frank B. Myers, III , John Robert Waldeisen , Ivan Krastev Dimov
IPC: B01L3/00 , G01N27/447 , C12Q1/6844
Abstract: Systems and methods for performing biological assays are provided herein. The systems and methods determine one or more characteristics of a nucleic acid amplification sample based on a modified optical property of the sample.
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公开(公告)号：US20180293350A1
公开(公告)日：2018-10-11
申请号：US15481349
申请日：2017-04-06
Applicant: Diassess Inc.
Inventor： Ivan Krastev Dimov , Frank B. Myers, III , John Robert Waldeisen , Debkishore Mitra
IPC: G06F19/00 , A61B5/00 , G01N33/569 , C12Q1/70 , G06T7/00
CPC classification number: G06F19/321 , A61B5/0059 , A61B5/742 , C12Q1/701 , G01N33/56983 , G06F19/3456 , G06T7/0012 , G06T2207/30072 , G16H50/20
Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.
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公开(公告)号：US20190094114A1
公开(公告)日：2019-03-28
申请号：US16081799
申请日：2017-03-14
Applicant: Diassess Inc.
Inventor： Frank B. Myers, III , Wei Hsuan Ho , Debkishore Mitra , John Robert Waldeisen , Ivan Krastev Dimov , Ryan C. Griswold , Bruce Richardson
Abstract: Devices and methods for preparing and delivering biological assay samples are provided herein. Components of such devices include a sample receiving module within which a biological assay sample can be prepared and a cap, which when operatively coupled with the sample receiving module, pressurizes the module. These devices can be employed for subsequently delivering a biological assay sample.
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公开(公告)号：US20190060895A1
公开(公告)日：2019-02-28
申请号：US16081800
申请日：2017-03-14
Applicant: Diassess Inc.
Inventor： Frank B. Myers, III , Debkishore Mitra , John Robert Waldeisen , Ivan Krastev Dimov
Abstract: Devices and methods for modifying optical properties of biological samples or aspects thereof are provided. The subject methods include generating a reaction product with a device and reacting the reaction product to sufficiently modify an optical property to allow detection of the modified optical property.
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公开(公告)号：US20170044599A1
公开(公告)日：2017-02-16
申请号：US15306240
申请日：2015-04-24
Applicant: DIASSESS INC.
Inventor： Debkishore Mitra , Ivan Krastev Dimov , John Robert Waldeisen
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/6846 , C12Q2527/119 , C12Q2527/125 , C12Q2563/173
Abstract: Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces an amplification reaction product if the sample contains a target nucleic acid template molecule. The reaction mix includes an enzyme for catalyzing the amplification reaction, and at least one halochromic agent. If the target nucleic acid template molecule is present, the amplification reaction changes the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating the presence of the target nucleic acid. If the target nucleic acid template molecule is not present, the amplification reaction does not generate an adequate number of protons to sufficiently change the starting pH of the reaction mix to cause a detectable colorimetric change of the halochromic agent, thereby indicating that the amplification reaction product has not been produced.
Abstract translation: 比色法用于检测扩增反应产物。 在发生扩增反应的条件下使样品与反应混合物接触，如果样品含有靶核酸模板分子，则产生扩增反应产物。 反应混合物包括用于催化扩增反应的酶和至少一种卤代色素。 如果存在靶核酸模板分子，则扩增反应改变反应混合物的起始pH，以引起卤色变色剂的可检测的比色变化，从而指示靶核酸的存在。 如果目标核酸模板分子不存在，则扩增反应不产生足够数量的质子，以充分改变反应混合物的起始pH，引起卤代色素的可检测的比色变化，从而表明扩增反应产物 尚未制作。
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