公开(公告)号：US20130150626A1

公开(公告)日：2013-06-13

申请号：US13704406

申请日：2011-06-14

Applicant: Pascal Mertens ,  Dirk De Vos ,  Bart Steenackers

Inventor： Pascal Mertens ,  Dirk De Vos ,  Bart Steenackers

IPC: C07C45/66

CPC classification number: C07C45/66 ,  C07C51/36 ,  C12C3/12 ,  C07C59/90

Abstract: The invention relates to a process for the production of hexahydro-iso-alpha-acids starting from iso-alpha-acids (or tetrahydro-iso-alpha-acids) in which iso-alpha-acids (or tetrahydro-iso-alpha-acids) are mixed with a heterogeneous ruthenium containing catalyst, that catalyzes the hydrogenation from iso-alpha-acids or tetrahydro-iso-alpha-acids to hexahydro-iso-alpha-acids, either in solvent-free conditions, or in the presence of a solvent phase (e.g. carbon dioxide, water, ethanol or another organ-ic solvent, or mixtures thereof), and in the absence or presence of other hop compounds (such as beta-acids). The resulting mix-ture is then subjected to a temperature at which the iso-alpha-acid (or tetrahydro-iso-alpha-acid) containing reaction medium is sufficiently low in viscosity to allow easy mixing with the heterogeneous ruthenium containing catalyst and held under a hydrogen containing atmosphere (either pure hydrogen gas or mixed with an inert gas) for a reaction tune sufficient to effect high conver-sion of the iso-alpha-acid (or tetrahydro-iso-alpha-acid) reactant into the hexahydro-iso-alpha-acid product. The molar ratio of iso-alpha-acid or tetrahydro-iso-alpha-acid to ruthenium varies between 1:1 and 2000:1. After the hydrogenation process, the hetero-geneous ruthenium containing catalyst can be separated from the hexahydro-iso-alpha-acid product phase by centrifugation, filtra-tion, decantation or other liquid-solid separation techniques. The hydrogenation process can be performed batch-wise or alterna-tively in continuous mode.

Abstract translation: 本发明涉及从异-α-酸（或四氢异α-酸）开始制备六氢异-5-酸的方法，其中异-α-酸（或四氢异α-酸） ）与含异丁烯的含钌催化剂混合，催化剂在无溶剂条件下或在无水条件下催化从异-α-酸或四氢异-α-酸氢化成六氢异-α-酸 溶剂相（如二氧化碳，水，乙醇或其他有机溶剂或其混合物），以及其它啤酒花化合物（如β-酸）不存在或不存在时。 然后将所得混合物经受含有异-α酸（或四氢异α-酸）的反应介质的粘度足够低的温度，以容易地与含异丁烯的含钌催化剂混合并保持在 用于反应曲线的氢气气氛（纯氢气或惰性气体混合）足以使异α酸（或四氢异α-酸）反应物高效转化为六氢异构体 -α-酸产物。 异-α-酸或四氢异-α-酸与钌的摩尔比在1:1至2000:1之间变化。 在氢化过程之后，通过离心，过滤，倾析或其它液固分离技术，可以将异质含钌的催化剂与六氢 - 异α-酸产物相分离。 氢化过程可以分批进行或以连续模式交替进行。

公开(公告)号：US08710273B2

公开(公告)日：2014-04-29

申请号：US13643305

申请日：2011-04-28

Applicant: Luc De Cooman ,  Dirk De Vos ,  Pascal Mertens ,  Bart Steenackers

Inventor： Luc De Cooman ,  Dirk De Vos ,  Pascal Mertens ,  Bart Steenackers

IPC: C07C45/67

CPC classification number: C12C3/12 ,  C12C3/08 ,  C12C3/10 ,  Y02P20/582

Abstract: The invention relates to a process for the production of iso-alpha-acids starting from hop alpha-acids in which an hop alpha-acid containing feed is contacted with a heterogeneous alkaline earth metal based catalyst, that essentially does not dissolve in the alpha-acid containing feed or in the iso-alpha-acid product phase, either in solvent-free conditions or in the presence of water, carbon dioxide, or an organic solvent or a mixture thereof. The resulting mixture is subjected to a temperature of at least 293 K, preferably under an inert atmosphere, for a time sufficient to effect high conversion of the alpha-acid reactant into the iso-alpha-acid product. The molar ratio of alpha-acid to earth alkaline metal (Mg, Ca, Sr, Ba) varies preferably between 0.2 and 20. After the isomerization process, the heterogeneous alkaline earth metal based catalyst can be quantitatively separated from the iso-alpha-acid product phase by liquid-solid separation techniques.

Abstract translation: 本发明涉及从啤酒花α-酸开始生产异-α酸的方法，其中含啤酒花酸的进料与非均相碱土金属的催化剂接触，其基本上不溶于α-烯烃， 含酸进料或异α酸产物相中，在无溶剂条件下或在水，二氧化碳或有​​机溶剂或其混合物存在下进行。 将所得混合物经受至少293K的温度，优选在惰性气氛下进行足以实现α-酸反应物高度转化成异α酸产物的时间。 α-酸与碱土金属（Mg，Ca，Sr，Ba）的摩尔比优选在0.2和20之间变化。在异构化过程之后，异相碱土金属的催化剂可以从异α酸定量分离 产物相通过液固分离技术。

公开(公告)号：US20130060066A1

公开(公告)日：2013-03-07

申请号：US13643305

申请日：2011-04-28

Applicant: Luc De Cooman ,  Dirk De Vos ,  Pascal Mertens ,  Bart Steenackers

Inventor： Luc De Cooman ,  Dirk De Vos ,  Pascal Mertens ,  Bart Steenackers

IPC: C07C45/67

CPC classification number: C12C3/12 ,  C12C3/08 ,  C12C3/10 ,  Y02P20/582

Abstract: The invention relates to a process for the production of iso-alpha-acids starting from hop alpha-acids in which an hop alpha-acid containing feed is contacted with a heterogeneous alkaline earth metal based catalyst, that essentially does not dissolve in the alpha-acid containing feed or in the iso-alpha-acid product phase, either in solvent-free conditions or in the presence of water, carbon dioxide, or an organic solvent or a mixture thereof. The resulting mixture is subjected to a temperature of at least 293 K, preferably under an inert atmosphere, for a time sufficient to effect high conversion of the alpha-acid reactant into the iso-alpha-acid product. The molar ratio of alpha-acid to earth alkaline metal (Mg, Ca, Sr, Ba) varies preferably between 0.2 and 20. After the isomerisation process, the heterogeneous alkaline earth metal based catalyst can be quantitatively separated from the iso-alpha-acid product phase by liquid-solid separation techniques.

Abstract translation: 本发明涉及从啤酒花α-酸开始生产异-α酸的方法，其中含啤酒花酸的进料与非均相碱土金属的催化剂接触，其基本上不溶于α-烯烃， 含酸进料或异α酸产物相中，在无溶剂条件下或在水，二氧化碳或有​​机溶剂或其混合物存在下进行。 将所得混合物经受至少293K的温度，优选在惰性气氛下进行足以实现α-酸反应物高度转化成异α酸产物的时间。 α-酸与碱土金属（Mg，Ca，Sr，Ba）的摩尔比优选在0.2和20之间变化。在异构化过程之后，异相碱土金属的催化剂可以与异α酸定量分离 产物相通过液固分离技术。

公开(公告)号：US08766013B2

公开(公告)日：2014-07-01

申请号：US13704406

申请日：2011-06-14

Applicant: Pascal Mertens ,  Dirk De Vos ,  Bart Steenackers

Inventor： Pascal Mertens ,  Dirk De Vos ,  Bart Steenackers

IPC: C07C45/66

CPC classification number: C07C45/66 ,  C07C51/36 ,  C12C3/12 ,  C07C59/90

Abstract: The invention relates to a process for the production of hexahydro-iso-alpha-acids starting from iso-alpha-acids (or tetrahydro-iso-alpha-acids) in which iso-alpha-acids (or tetrahydro-iso-alpha-acids) are mixed with a heterogeneous ruthenium containing catalyst, that catalyzes the hydrogenation from iso-alpha-acids or tetrahydro-iso-alpha-acids to hexahydro-iso-alpha-acids, either in solvent-free conditions, or in the presence of a solvent phase (e.g. carbon dioxide, water, ethanol or another organic solvent, or mixtures thereof), and in the absence or presence of other hop compounds (such as beta-acids). The resulting mixture is then subjected to a temperature at which the iso-alpha-acid (or tetrahydro-iso-alpha-acid) containing reaction medium is sufficiently low in viscosity to allow easy mixing with the heterogeneous ruthenium containing catalyst and held under a hydrogen containing atmosphere (either pure hydrogen gas or mixed with an inert gas) for a reaction time sufficient to effect high conversion of the iso-alpha-acid (or tetrahydro-iso-alpha-acid) reactant into the hexahydro-iso-alpha-acid product.

Abstract translation: 本发明涉及从异-α-酸（或四氢异α-酸）开始制备六氢异-5-酸的方法，其中异-α-酸（或四氢异α-酸） ）与含异丁烯的含钌催化剂混合，催化剂在无溶剂条件下或在无水条件下催化从异-α-酸或四氢异-α-酸氢化成六氢异-α-酸 溶剂相（如二氧化碳，水，乙醇或其他有机溶剂，或其混合物），以及其它啤酒花化合物（如β-酸）不存在或不存在时。 然后将所得混合物进行含有异-α-酸（或四氢异α-酸）的反应介质的粘度足够低的温度，以便容易地与非均相含钌催化剂混合并保持在氢气 反应时间足以使异α酸（或四氢异α-酸）反应物转化为六氢异-α酸的反应时间（或纯氢气或与惰性气体混合） 产品。

公开(公告)号：US09909088B2

公开(公告)日：2018-03-06

申请号：US13876915

申请日：2011-09-29

Applicant: Dirk De Vos ,  Pascal Mertens

Inventor： Dirk De Vos ,  Pascal Mertens

IPC: C12C3/12

CPC classification number: C12C3/12

Abstract: The invention relates to a process for the production of iso-alpha-acids starting from alpha-acids in which an alpha-acid containing hop extract is mixed with a carbon-containing chemical compound with one or more functional groups containing a (basic) nitrogen atom with a lone pair (or mixtures thereof), either in solvent-free conditions or in the presence of solvents and preferably under an oxygen-free atmosphere. The resulting mixture is subjected to a temperature of at least 278 K for a time sufficient to effect the intended conversion of the alpha-acid reactant into the iso-alpha-acid product. The present invention further relates to iso-alpha-acid compositions obtained by said improved isomerisation process and to the use of said iso-alpha-acid compositions as bittering formulation and/or as source to obtain reduced or hydrogenated iso-alpha-acid compositions.

公开(公告)号：US20130209653A1

公开(公告)日：2013-08-15

申请号：US13876915

申请日：2011-09-29

Applicant: Dirk De Vos ,  Pascal Mertens

Inventor： Dirk De Vos ,  Pascal Mertens

IPC: C12C3/12

CPC classification number: C12C3/12

Abstract: The invention relates to a process for the production of iso-alpha-acids starting from alpha-acids in which an alpha-acid containing hop extract is mixed with a carbon-containing chemical compound with one or more functional groups containing a (basic) nitrogen atom with a lone pair (or mixtures thereof), either in solvent-free conditions or in the presence of solvents and preferably under an oxygen-free atmosphere. The resulting mixture is subjected to a temperature of at least 278 K for a time sufficient to effect the intended conversion of the alpha-acid reactant into the iso-alpha-acid product. The present invention further relates to iso-alpha-acid compositions obtained by said improved isomerisation process and to the use of said iso-alpha-acid compositions as bittering formulation and/or as source to obtain reduced or hydrogenated iso-alpha-acid compositions.

Abstract translation: 本发明涉及从α-酸开始生产异α酸的方法，其中将含有α-酸的啤酒花提取物与含碳化合物与含有（碱）氮的一个或多个官能团混合 原子与一对（或其混合物），无溶剂条件下或在溶剂存在下，优选在无氧气氛下进行。 将所得混合物经受至少278K的温度足以实现将α-酸反应物预期转化成异α酸产物的时间。 本发明还涉及通过所述改进的异构化方法获得的异-α酸组合物和所述异-α-酸组合物作为苦味制剂和/或作为来源以获得还原或氢化异-α酸组合物的用途。

公开(公告)号：US20090162833A1

公开(公告)日：2009-06-25

申请号：US12096008

申请日：2006-12-08

Applicant: Pascal Mertens ,  Laurence Denorme ,  Thierry Leclipteux

Inventor： Pascal Mertens ,  Laurence Denorme ,  Thierry Leclipteux

IPC: C12Q1/70 ,  G01N21/64 ,  G01N33/558 ,  G01N33/569

CPC classification number: G01N33/558 ,  G01N33/54386 ,  G01N33/569

Abstract: Devices for detecting analytes or analogues thereof in a biological sample are disclosed. The device includes a solid support. The solid support has several juxtaposed zones. The sample is able to migrate from a sample receiving zone towards a detection zone. The analyte, if present, is detected in the detection zone. Both zones have material allowing a capillary flow of the sample through the zones. In between the zones, there is an intermediate zone of transport of the sample which is free from any capillary material. This allows the ample to migrate by gravitational forces on the support laid in a vertical position. Methods for detecting analytes or analogues thereof in a biological sample using the device are also disclosed.

Abstract translation: 公开了用于检测生物样品中其分析物或类似物的装置。 该设备包括坚固的支持。 坚实的支持有几个并置的区域。 样品能够从样品接收区迁移到检测区。 在检测区域中检测分析物（如果存在）。 两个区域都具有允许样品通过区域的毛细管流动的材料。 在这些区域之间，存在不含任何毛细管材料的样品的中间输送区。 这样就可以通过在垂直位置上放置的支撑物上的重力来迁移。 还公开了使用该装置检测生物样品中的分析物或其类似物的方法。

公开(公告)号：US20070202497A1

公开(公告)日：2007-08-30

申请号：US10555154

申请日：2004-04-30

Applicant: Ismaelle Renuart ,  Pascal Mertens ,  Thierry Leclipteux

Inventor： Ismaelle Renuart ,  Pascal Mertens ,  Thierry Leclipteux

IPC: C12Q1/68 ,  G01N33/558

CPC classification number: G01N33/54386 ,  C12Q1/6834 ,  G01N30/90 ,  G01N30/92 ,  G01N33/558 ,  C12Q2565/625 ,  C12Q2565/137 ,  C12Q2545/101 ,  C12Q2563/131 ,  C12Q2537/125

Abstract: The present invention relates to methods and devices for detecting one or more analytes in a biological sample, preferably a clean liquid sample. This invention in particular relates to improved rapid tests such as “dipsticks”, “lateral flow” devices and “flow-through” devices. The invention in particular relates to oligochromatographic devices that make use of a peptide- or hapten-coupled oligonucleotide and a reagent specifically recognizing the hapten or peptide and a conjugated probe that hybridizes specifically to a target sequence. It allows to detect specifically the presence of a polynucleotides directly or after molecular amplification steps with the use of a specific genuine internal control and a chromatographic control.

Abstract translation: 本发明涉及用于检测生物样品中优选清洁液体样品中的一种或多种分析物的方法和装置。 本发明特别涉及改进的快速测试，例如“骰子”，“横向流动”装置和“流通”装置。 本发明特别涉及利用肽或半抗原偶联的寡核苷酸和特异性识别半抗原或肽的试剂和与靶序列特异性杂交的共轭探针的低色谱装置。 它允许通过使用特定的真正的内部对照和色谱控制来直接或在分子扩增步骤之后特异性地检测多核苷酸的存在。

公开(公告)号：US08389209B2

公开(公告)日：2013-03-05

申请号：US12096008

申请日：2006-12-08

Applicant: Pascal Mertens ,  Laurence Denorme ,  Thierry Leclipteux

Inventor： Pascal Mertens ,  Laurence Denorme ,  Thierry Leclipteux

IPC: C12Q1/70 ,  G01N33/53

CPC classification number: G01N33/558 ,  G01N33/54386 ,  G01N33/569

Abstract: Devices for detecting analytes or analogues thereof in a biological sample are disclosed. The device includes a solid support. The solid support has several juxtaposed zones. The sample is able to migrate from a sample receiving zone towards a detection zone. The analyte, if present, is detected in the detection zone. Both zones have material allowing a capillary flow of the sample through the zones. In between the zones, there is an intermediate zone of transport of the sample which is free from any capillary material. This allows the ample to migrate by gravitational forces on the support laid in a vertical position. Methods for detecting analytes or analogues thereof in a biological sample using the device are also disclosed.

Abstract translation: 公开了用于检测生物样品中其分析物或类似物的装置。 该设备包括坚固的支持。 坚实的支持有几个并置的区域。 样品能够从样品接收区迁移到检测区。 在检测区域中检测分析物（如果存在）。 两个区域都具有允许样品通过区域的毛细管流动的材料。 在这些区域之间，存在不含任何毛细管材料的样品的中间输送区。 这样就可以通过在垂直位置上放置的支撑物上的重力来迁移。 还公开了使用该装置检测生物样品中的分析物或其类似物的方法。

公开(公告)号：US20060199278A1

公开(公告)日：2006-09-07

申请号：US11265321

申请日：2005-11-02

Applicant: Thierry Leclipteux ,  Stephane Degallaix ,  Laurence Denorme ,  Pascal Mertens ,  Christine Olungu

Inventor： Thierry Leclipteux ,  Stephane Degallaix ,  Laurence Denorme ,  Pascal Mertens ,  Christine Olungu

IPC: G01N33/558

CPC classification number: G01N33/558

Abstract: The present invention relates to methods and devices for detecting one or more analytes or analyte products in a biological sample. This invention in particular relates to improved rapid tests such as “dipsticks” and “lateral flow” devices. The invention in particular relates to chromatographic device made of two active sides, in order to allow multiplex detections, quantitative or semi-quantitative detections, use of multiple sizes and kinds of particles or microspheres, use of different nitrocellulose porosities, use of different kinds of membranes. The devices described in this invention allow to detect or identify various biologicals or chemicals with one manipulation.

Abstract translation: 本发明涉及用于检测生物样品中一种或多种分析物或分析物产物的方法和装置。 本发明特别涉及改进的快速测试，例如“骰子”和“横向流动”装置。 本发明特别涉及由两个活性侧面制成的色谱装置，以允许多重检测，定量或半定量检测，使用多种尺寸和种类的颗粒或微球体，使用不同的硝酸纤维素孔隙率，使用不同种类的 膜。 本发明描述的装置允许通过一次操纵来检测或识别各种生物制品或化学品。