公开(公告)号：US11474085B2

公开(公告)日：2022-10-18

申请号：US15963809

申请日：2018-04-26

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, Jr. ,  Jack Saloio

IPC: G01N30/76 ,  G01N30/46 ,  G01N30/72 ,  G01N33/543 ,  B01D15/38 ,  B01D15/18 ,  C07K1/22 ,  G01N30/02 ,  C12M1/42 ,  C12N13/00

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US20180362918A1

公开(公告)日：2018-12-20

申请号：US16010296

申请日：2018-06-15

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Brian Dutra ,  Rudolf Gilmanshin ,  Jason Dionne ,  Walter M. Presz, JR. ,  Benjamin Ross-Johnsrud ,  Goutam Ghoshal ,  Kedar Chitale

IPC: C12M1/00 ,  A61K35/12

Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

公开(公告)号：US11708572B2

公开(公告)日：2023-07-25

申请号：US16421459

申请日：2019-05-23

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Kedar C. Chitale ,  Krishna N. Kumar ,  Walter M. Presz, Jr. ,  Ruan Zhang ,  Benjamin Ross-Johnsrud ,  Rudolf Gilmanshin ,  Natalia Rodionova ,  Rui Tostoes

IPC: C12N13/00 ,  B01D21/28 ,  G01N15/14 ,  A61M1/36 ,  B01L3/00 ,  C12M1/00 ,  G01N15/00 ,  G01N15/10

CPC classification number: C12N13/00 ,  A61M1/3678 ,  B01D21/283 ,  B01L3/502761 ,  C12M47/04 ,  G01N15/1484 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0436 ,  B01L2400/0439 ,  G01N2015/0053 ,  G01N2015/1006 ,  G01N2015/149

Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap, retain or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes. The acoustic field may be generated, for example, in an acoustic angled wave device or in an acoustic fluidized bed.

公开(公告)号：US11459540B2

公开(公告)日：2022-10-04

申请号：US15983823

申请日：2018-05-18

Applicant: FloDesign Sonics, Inc.

Inventor： Rui Tostoes ,  Bart Lipkens ,  Kedar Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, Jr. ,  Jack Saloio

IPC: C12M1/00 ,  C12M1/42 ,  B01D15/38 ,  C12N13/00 ,  B01D15/18

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US20190011407A9

公开(公告)日：2019-01-10

申请号：US15963809

申请日：2018-04-26

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, JR. ,  Jack Saloio

IPC: G01N30/76 ,  G01N30/46 ,  G01N30/72 ,  G01N33/543

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US20220380748A1

公开(公告)日：2022-12-01

申请号：US17753750

申请日：2020-10-28

Applicant: FloDesign Sonics, Inc.

Inventor： Krishna N. Kumar ,  Bart Lipkens ,  Rui Tostoes

IPC: C12N13/00 ,  B01J13/04 ,  C12M1/00

Abstract: Microparticles and nanoparticles made of various materials that are used in various configurations are disclosed. The particles may be perfluorocarbon droplets with a lipid coating. The particles may be used in an acoustic cell selection process. The droplets are highly acoustically responsive and can be retained against fluid flow by an acoustic field. Such particles can be used in the separation, segregation, differentiation, modification or filtration of a system.

公开(公告)号：US20200206730A1

公开(公告)日：2020-07-02

申请号：US16557994

申请日：2019-08-30

Applicant: FloDesign Sonics, Inc.

Inventor： Rui Tostoes ,  Bart Lipkens ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, JR. ,  Jack Saloio

IPC: B01L3/00

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US20190062690A1

公开(公告)日：2019-02-28

申请号：US15983823

申请日：2018-05-18

Applicant: FloDesign Sonics, Inc.

Inventor： Rui Tostoes ,  Bart Lipkens ,  Kedar Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, JR. ,  Jack Saloio

IPC: C12M1/00 ,  B01D15/38 ,  C12M1/42 ,  C12N13/00

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US20190276815A1

公开(公告)日：2019-09-12

申请号：US15916270

申请日：2018-03-08

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Brian Dutra ,  Rudolf Gilmanshin ,  Jason Dionne ,  Walter M. Presz, JR. ,  Benjamin Ross-Johnsrud ,  Goutam Ghoshal ,  Kedar Chitale

IPC: C12N13/00 ,  C12M1/00

Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

公开(公告)号：US20180275106A1

公开(公告)日：2018-09-27

申请号：US15963809

申请日：2018-04-26

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, JR. ,  Jack Saloio

IPC: G01N30/76 ,  G01N30/46 ,  G01N30/72 ,  G01N33/543

CPC classification number: G01N30/76 ,  B01D15/1807 ,  B01D15/3823 ,  B01D15/3866 ,  C07K1/22 ,  C12M35/04 ,  C12N13/00 ,  G01N30/462 ,  G01N30/7293 ,  G01N33/54313 ,  G01N2030/027

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.