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1.发明授权Fluid flow conduits and apparatus and methods for making and joining fluid conduits 有权流体流动管道以及用于制造和连接流体管道的装置和方法公开(公告)号：US09199070B2
公开(公告)日：2015-12-01
申请号：US14110010
申请日：2012-12-12
Applicant: Fenwal, Inc.
Inventor： Christopher Wegener , Kyungyoon Min , Mark Brierton , Benjamin Kusters , James Madsen , William H. Cork
IPC: B29C65/36 , B29C65/02 , B29C65/34 , A61M39/14 , B29C65/30 , B29C65/32 , B29C65/20 , B29C65/78 , B29C65/48 , B29C65/50 , B29C65/00
CPC classification number: A61M39/143 , A61M39/14 , B29C65/022 , B29C65/2015 , B29C65/203 , B29C65/30 , B29C65/32 , B29C65/3444 , B29C65/3456 , B29C65/36 , B29C65/3644 , B29C65/3656 , B29C65/4855 , B29C65/5021 , B29C65/5057 , B29C65/7841 , B29C66/0342 , B29C66/1142 , B29C66/3494 , B29C66/5221 , B29C66/5223 , B29C66/52298 , B29C66/5346 , B29C66/5414 , B29C66/543 , B29C66/71 , B29C66/72321 , B29C66/73115 , B29C66/73141 , B29C66/857 , B29C66/91231 , B29C66/91421 , B29C66/91651 , B29C66/919 , B29C66/91933 , B29C66/949 , B29C66/954 , B29K2027/06 , B29K2023/12 , B29K2067/003
Abstract: Fluid flow conduits (14a, 14b) and apparatus (40) and methods for joining the conduits (14a, 14b), preferably in a sterile manner, are disclosed. Each conduit (14, 14b) has a polymeric open end that is sealed by a sealing member (26a, 26b) that may include a heating element (28). The polymeric end material is melted, the sealing members (26a, 26b) are moved to expose the melted open ends of the conduits (14a, 14b) and the ends are brought together to form a fused or welded connection (12) between the conduits (14a, 14b).
Abstract translation: 公开了优选以无菌方式连接导管（14a，14b）的流体流动导管（14a，14b）和装置（40）和方法。 每个导管（14,14b）具有由可包括加热元件（28）的密封构件（26a，26b）密封的聚合物开口端。 聚合物端部材料被熔化，密封件（26a，26b）被移动以露出导管（14a，14b）的熔化的开口端，并且端部被接合在一起，以形成导管之间的熔接或焊接连接（12） （14a，14b）。
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公开(公告)号：US20150218517A1
公开(公告)日：2015-08-06
申请号：US14422032
申请日：2013-03-11
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Kyungyoon Min , Christopher Wegener , William H. Cork
IPC: C12N5/078
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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公开(公告)号：US09164078B2
公开(公告)日：2015-10-20
申请号：US13788164
申请日：2013-03-07
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Benjamin Kusters , Christopher Wegener
IPC: G01N33/49 , A61B5/145 , A61B5/1455 , G01N21/3577
CPC classification number: G01N33/49 , A61B5/14535 , A61B5/14557 , G01N21/3577
Abstract: A separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, including prediction of the hematocrit of the whole blood using a light source and an optical sensor.
Abstract translation: 公开了一种分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种旋转膜分离器。 公开了用于将先前收集的全血的单位分离成选定的血液成分（例如浓缩红细胞和血浆）的自动化系统和方法，包括使用光源和光学传感器预测全血的血细胞比容。
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4.发明申请MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 有权膜分离装置，系统和使用方法以及数据管理系统和方法公开(公告)号：US20150175967A1
公开(公告)日：2015-06-25
申请号：US14625024
申请日：2015-02-18
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Christopher Wegener , Kyungyoon Min
IPC: C12N5/078
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
Abstract translation: 公开了膜分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施方案中，提供了纺丝膜分离器，其中在纺丝膜和壳体之间的间隙中形成至少两个区域或区域，使得两个区域之间的流体的混合被相关联的径向肋或脊部抑制 通过纺丝膜减少纺丝膜和壳体之间的间隙以限定两个流体区域，脊部将两个区域中的流体隔离以最小化两者之间的混合。 公开了自动化系统和方法，用于将先前收集的全血的单元分离成选定的血液成分，例如浓缩的红细胞和血浆，以单次从供体中收集红细胞和血浆，并进行细胞洗涤。 还公开了数据管理系统和方法以及启动方法。
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5.发明申请FLUID FLOW CONDUITS AND APPARATUS AND METHODS FOR MAKING AND JOINING FLUID CONDUITS 审中-公开流体流量和流体流量的制作和接合方法公开(公告)号：US20140077488A1
公开(公告)日：2014-03-20
申请号：US14088781
申请日：2013-11-25
Applicant: Fenwal, Inc.
Inventor： Christopher Wegener , Kyungyoon Min , Mark Brierton , Benjamin Kusters , James Madsen , William H. Cork
CPC classification number: A61M39/143 , A61M39/14 , B29C65/022 , B29C65/2015 , B29C65/203 , B29C65/30 , B29C65/32 , B29C65/3444 , B29C65/3456 , B29C65/36 , B29C65/3644 , B29C65/3656 , B29C65/4855 , B29C65/5021 , B29C65/5057 , B29C65/7841 , B29C66/0342 , B29C66/1142 , B29C66/3494 , B29C66/5221 , B29C66/5223 , B29C66/52298 , B29C66/5346 , B29C66/5414 , B29C66/543 , B29C66/71 , B29C66/72321 , B29C66/73115 , B29C66/73141 , B29C66/857 , B29C66/91231 , B29C66/91421 , B29C66/91651 , B29C66/919 , B29C66/91933 , B29C66/949 , B29C66/954 , B29K2027/06 , B29K2023/12 , B29K2067/003
Abstract: Fluid flow conduits and apparatus and methods for joining the conduits, preferably in a sterile manner, are disclosed. Each conduit has a polymeric open end that is sealed by a sealing member that may include a heating element. The polymeric end material is melted, the sealing members are moved to expose the melted open ends of the conduits and the ends are brought together to form a fused or welded connection between the conduits.
Abstract translation: 公开了流体流动管道以及用于连接管道的装置和方法，优选以无菌方式。 每个管道具有聚合物开口端，该开口端由可包括加热元件的密封构件密封。 聚合物端部材料被熔化，密封构件被移动以暴露导管的熔化的开口端，并且端部被带到一起以形成导管之间的熔接或焊接连接。
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Patent Agency Ranking
公开(公告)号：US09770545B2
公开(公告)日：2017-09-26
申请号：US15177426
申请日：2016-06-09
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Kyungyoon Min , Christopher Wegener , William H. Cork
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.
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公开(公告)号：US09717838B2
公开(公告)日：2017-08-01
申请号：US15014177
申请日：2016-02-03
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Christopher Wegener , Kyungyoon Min
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A method and system for collecting leukoreduced red blood cells employing a spinning membrane separator including a housing having an upper end region and a lower end region in an operating position with a red blood cell outlet in the upper end region of the housing and a whole blood inlet in the lower end region of the housing. The method and system provide for flowing additive solution into the whole blood inlet of the housing to prime the separator; flowing whole blood into the whole blood inlet of the housing; separating red blood cells from the whole blood; flowing separated red blood cells out of the red blood cell outlet of the housing; combining the separated red blood cells with additive solution: passing the separated red blood cells and additive solution combination through a leukoreduction filter; and collecting the filtered red blood cells and additive solution.
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公开(公告)号：US10307582B2
公开(公告)日：2019-06-04
申请号：US14088781
申请日：2013-11-25
Applicant: Fenwal, Inc.
Inventor： Christopher Wegener , Kyungyoon Min , Mark Brierton , Benjamin Kusters , James Madsen , William H. Cork
IPC: A61M39/14 , B29C65/30 , B29C65/32 , B29C65/00 , B29C65/02 , B29C65/20 , B29C65/36 , B29C65/78 , B29C65/58 , B29C65/72 , B29C65/34 , B29C65/48 , B29C65/50
Abstract: Fluid flow conduits and apparatus and methods for joining the conduits, preferably in a sterile manner, are disclosed. Each conduit has a polymeric open end that is sealed by a sealing member that may include a heating element. The polymeric end material is melted, the sealing members are moved to expose the melted open ends of the conduits and the ends are brought together to form a fused or welded connection between the conduits.
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公开(公告)号：US20160279316A1
公开(公告)日：2016-09-29
申请号：US15177426
申请日：2016-06-09
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Kyungyoon Min , Christopher Wegener , William H. Cork
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.
Abstract translation: 提供使用纺丝膜分离器收集双倍体积的红细胞的方法和系统，通过该方法和系统从供体中取出第一量的全血; 第一量的全血流入纺丝膜分离器; 其中它被分成第一量的红细胞和第一量的血浆。 然后将第一数量的红细胞和第一量的血浆流入相应的收集容器，并且将第一量的等离子体的至少一部分返回给供体。 从供体排出的第二量全血，然后使用纺丝膜分离器分离成第二量的红细胞和第二量的血浆。 然后将第二数量的红细胞和第二量的血浆流到相应的收集容器，并且将第二量的等离子体的至少一部分返回给供体。
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10.发明申请公开(公告)号：US20160184504A1
公开(公告)日：2016-06-30
申请号：US15066047
申请日：2016-03-10
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Kyungyoon Min , Christopher Wegener
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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