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    Automated Splitting of a Fluid
    1.
    发明申请
    Automated Splitting of a Fluid 有权

    公开(公告)号：US20250137833A1

    公开(公告)日：2025-05-01

    申请号：US19008489

    申请日：2025-01-02

    Applicant: Fenwal, Inc.

    Inventor： James Madsen ,  Kyungyoon Min

    IPC: G01G13/26 ,  G01G13/00

    Abstract: A system for splitting a fluid includes a source support configured to support a source container of a fluid flow circuit and at least one satellite support, with each satellite support configured to support a different satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller is configured to control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale. The controller is configured to control the clamp system to selectively allow and prevent fluid flow from the source container to each satellite container based at least in part upon the weights measured by each weight scale. Fluid flow continues until the contents of each container have reached a target volume.

    Collection, genome editing, and washing of T-cell lymphocytes
    3.
    发明授权
    Collection, genome editing, and washing of T-cell lymphocytes 有权

    公开(公告)号：US12168087B2

    公开(公告)日：2024-12-17

    申请号：US16807254

    申请日：2020-03-03

    Applicant: Fenwal, Inc.

    Inventor： Kyungyoon Min ,  Benjamin E. Kusters

    IPC: C12N5/078 ,  A61K35/17 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  A61M1/38 ,  C12M1/00 ,  C12M1/42 ,  C12N5/00 ,  C12N5/0783 ,  C12N5/10 ,  C12N13/00 ,  C12N15/85

    Abstract: Blood from a blood source is drawn into a fluid flow circuit. A mononuclear cell product is separated from the blood, followed by at least a portion of the mononuclear cell product being conveyed into an electroporation device without disconnecting the blood source from the fluid flow circuit. The electroporation device opens pores in a membrane of at least one of the cells of the mononuclear cell product to allow DNA material (which is added to the mononuclear cell product prior to electroporation) to enter and modify the genome of the cell. At least a portion of the modified mononuclear cell product is returned to the blood source. The mononuclear cell product may be washed prior to being conveyed into the electroporation device. The modified mononuclear cell product may be washed after exiting the electroporation device.

    Packaging Tray for a Blood Processing Kit
    4.
    发明公开
    Packaging Tray for a Blood Processing Kit 审中-公开

    公开(公告)号：US20240245840A1

    公开(公告)日：2024-07-25

    申请号：US18420050

    申请日：2024-01-23

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  James Gregory Madsen ,  Kyungyoon Min

    IPC: A61M1/02 ,  B04B5/04 ,  B04B11/02

    CPC classification number: A61M1/0277 ,  B04B5/0442 ,  B04B11/02 ,  A61M2205/3393 ,  A61M2209/06

    Abstract: A packaging tray for use in a blood processing system including a blood processing device having device components arranged on a component surface and a removable fluid flow circuit having circuit components configured to interact with corresponding device components, wherein the packaging tray configured to be selectively arranged on and removable from the component surface. The packaging tray includes a first surface and a second surface opposite to the first surface and spaced apart by a thickness, component sections arranged at positions corresponding to positions of respective device components, the component sections respectively formed, at least partially, as openings extending through the thickness, and a plurality of recessed pathways formed on the first surface, the recessed pathways extending between the component sections. A blood processing device may include the packaging tray, and a blood processing system may include a blood processing device and the packaging tray.

    Maximization Of Plasma Collection And Collection Of Buffy Coat Or White Blood Cell Layer Using Collected Plasma
    6.
    发明公开
    Maximization Of Plasma Collection And Collection Of Buffy Coat Or White Blood Cell Layer Using Collected Plasma 审中-公开

    公开(公告)号：US20240157038A1

    公开(公告)日：2024-05-16

    申请号：US18388871

    申请日：2023-11-13

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Richard I. Brown ,  Kyungyoon Min

    IPC: A61M1/36

    CPC classification number: A61M1/3693

    Abstract: A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge, separating the blood in the centrifuge into red blood cells and plasma, and collecting portions of the separated red blood cells and plasma. Subsequently, a portion of the collected red blood cells is pumped back into the centrifuge to collect an additional amount of the separated plasma. A buffy coat or white blood cell layer may be formed between the separated red blood cells and plasma in the centrifuge. If so, a portion of the collected plasma may be pumped back into the centrifuge to harvest the buffy coat or white blood cell layer.

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