公开(公告)号：US10525166B2

公开(公告)日：2020-01-07

申请号：US15889235

申请日：2018-02-06

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Shengmin Zhang ,  Yan Li ,  Hang Hao

IPC: A61L27/50 ,  A61L27/42 ,  A61L27/16 ,  C01B25/32

Abstract: The invention relates to a selenium-doped hydroxyapatite and a preparation method thereof. The selenium-doped hydroxyapatite provided is a single crystal comprising a rod-like structure, a uniform morphology, and a good dispersibility. The preparation method comprises adding a mixed solution of a phosphate and a selenite dropwise to a mixed solution of a calcium salt and a dispersing agent, and reacting for 1.5-2.5 hrs at a controlled temperature of 80-90° C., to obtain a solution of a calcium phosphate amorphous precursor, followed by performing a hydrothermal reaction at 190-210° C., to obtain a selenium-doped hydroxyapatite comprising a rod-like structure. Compared with selenium-doped hydroxyapatite with severe agglomeration, the selenium-doped hydroxyapatite provided in the present invention comprises good dispersibility and able to have better prevention of clogging problem in human body when in use, thus having a good prospect using as a multi-functional new material for bone repair in patients as a repair material for bone defects, an anti-tumor, etc.

公开(公告)号：US20190167848A1

公开(公告)日：2019-06-06

申请号：US15889235

申请日：2018-02-06

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Shengmin Zhang ,  Yan Li ,  Hang Hao

IPC: A61L27/50 ,  C01B25/32 ,  A61L27/42 ,  A61L27/16

Abstract: The invention relates to a selenium-doped hydroxyapatite and a preparation method thereof. The selenium-doped hydroxyapatite provided is a single crystal comprising a rod-like structure, a uniform morphology, and a good dispersibility. The preparation method comprises adding a mixed solution of a phosphate and a selenite dropwise to a mixed solution of a calcium salt and a dispersing agent, and reacting for 1.5-2.5 hrs at a controlled temperature of 80-90° C., to obtain a solution of a calcium phosphate amorphous precursor, followed by performing a hydrothermal reaction at 190-210° C., to obtain a selenium-doped hydroxyapatite comprising a rod-like structure. Compared with selenium-doped hydroxyapatite with severe agglomeration, the selenium-doped hydroxyapatite provided in the present invention comprises good dispersibility and able to have better prevention of clogging problem in human body when in use, thus having a good prospect using as a multi-functional new material for bone repair in patients as a repair material for bone defects, an anti-tumor, etc.