公开(公告)号：US12217953B2

公开(公告)日：2025-02-04

申请号：US17781449

申请日：2020-10-15

Applicant: Hitachi High-Tech Corporation

Inventor： Hideki Hasegawa ,  Masuyuki Sugiyama ,  Yuichiro Hashimoto

IPC: H01J49/00 ,  G01N27/623 ,  H01J49/04 ,  H01J49/16

Abstract: Provided are an ion source and a mass spectrometer that reduce a dead volume of the connecting part of a pipe to a capillary. An ion source has a capillary and a pipe. The capillary has a large-diameter part that forms a capillary upstream-side end face on an upstream side. The large-diameter part has a large-diameter part downstream side face on a downstream side. The pipe has a pipe downstream end face on the downstream side. A capillary retaining unit has a hole through which the capillary downstream-side end face is passable and a face on which the large-diameter part downstream side face is installable. The ion source includes a pipe retaining unit that retains the pipe. The capillary retaining unit and the pipe retaining unit are disposed such that the capillary upstream-side end face contacts the pipe downstream end face to connect the capillary to the pipe.

公开(公告)号：US12210003B2

公开(公告)日：2025-01-28

申请号：US17911763

申请日：2021-03-05

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Midori Tobita ,  Yuichiro Hashimoto ,  Nobuhiro Tsukada

IPC: G01N30/32

Abstract: A liquid chromatographic apparatus which removes air bubbles during preparatory operation for apparatus startup includes a liquid feeding pump to feed a solvent, an injector to inject a sample into the solvent, a separation column to receive the solvent and the sample through the injector and separate the sample into components, a detector to detect the components supplied from the separation column, a pressure sensor to measure a pressure in a solvent flow channel of the liquid feeding pump, and a controller to control a purge operation for removing air bubbles in the solvent flow channel by the liquid feeding pump, determine whether a pressure change amount in the solvent flow channel measured by the pressure sensor during the purge operation is a specified change amount or larger, and complete the air bubble removal operation when the pressure change amount is the specified change amount or larger.

公开(公告)号：US11955327B2

公开(公告)日：2024-04-09

申请号：US17433133

申请日：2020-01-22

Applicant: Hitachi High-Tech Corporation

Inventor： Kiyomi Yoshinari ,  Masuyuki Sugiyama ,  Yuichiro Hashimoto ,  Shin Imamura

IPC: H01J49/42 ,  G01N27/623 ,  G01T1/20 ,  G01T1/28

CPC classification number: H01J49/42 ,  G01N27/623 ,  G01T1/2018 ,  G01T1/28

Abstract: The present invention implements an ion detector with which it is possible to avoid direct collisions of negative ions with a scintillator, prevent degradation of the scintillator, prolong life of the scintillator, reduce the need for maintenance, and perform highly sensitive detection of both positive and negative ions. With respect to a reference line 65 connecting a central point 63 of a positive ion CD 52 and a central point 64 of a counter electrode 54, a central point 66 of a negative ion CD 53 is provided in a region of a side opposite to a region of a side of a central point 67 of a scintillator 56. Positive ions entering from an ion entrance 62 receive a deflection force and collide with the positive ion CD 52 to generate secondary electrons. The generated secondary electrons collide with the scintillator 56 to generate light. The generated light passes through a light guide 59 and is detected by a photomultiplier tube 58. A negative potential barrier is generated along the reference line 65. Negative ions entering form the ion entrance 62 are attracted to and collide with the negative ion CD 53 to generate positive ions. The generated positive ions collide with the positive ion CD 52 to generate secondary electrons. The generated secondary electrons collide with the scintillator 56 and are detected by the photomultiplier tube 58.

公开(公告)号：US20240060942A1

公开(公告)日：2024-02-22

申请号：US18261299

申请日：2021-12-07

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Yusuke Shimizu ,  Yoshito Watanabe ,  Yu Iijima ,  Shuhei Yamamura ,  Yuichiro Hashimoto

IPC: G01N30/60 ,  G01N30/54 ,  B01D15/16

CPC classification number: G01N30/6091 ,  G01N30/54 ,  B01D15/161 ,  G01N2030/027

Abstract: Provided is an analyzer column cartridge that can control the temperature of an analysis column while saving resources and costs. An analyzer column cartridge 1 includes: metal blocks 7, 8 that accommodate an analysis column 10 used in a liquid chromatography; and housings 2, 3 that accommodate the metal blocks 7, 8. A plurality of holes 11A, 11B, 11C, 11D, and 11E that communicate with an accommodation space of the analysis column 10 are formed in the metal block 8. The housing has a plurality of windows 6A, 6B, 6C, 6D, and 6E formed at positions facing the plurality of holes 11A, 11B, 11C, 11D, and 11E formed in the metal block 8.

公开(公告)号：US20230408459A1

公开(公告)日：2023-12-21

申请号：US18253987

申请日：2021-12-08

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Daisuke Kanai ,  Yuichiro Hashimoto

IPC: G01N30/24 ,  G01N35/02

CPC classification number: G01N30/24 ,  G01N35/02 ,  G01N2030/027

Abstract: Provided is an autosampler of a liquid chromatograph that can manage a sample container even in a case where the throughput of a pretreatment unit exceeds the throughput of the autosampler.
An autosampler of a liquid chromatograph includes a plurality of sample aspiration nozzles that aspirates a sample from sample containers installed at respective sample aspiration points; a sample transfer means that transfers the sample containers to the respective sample aspiration points; and a retraction point where one of the sample containers is put into the autosampler and one of the sample containers collected from the sample aspiration points can be held.

公开(公告)号：US11749517B2

公开(公告)日：2023-09-05

申请号：US17286054

申请日：2019-10-10

Applicant: Hitachi High-Tech Corporation

Inventor： Hideki Hasegawa ,  Masuyuki Sugiyama ,  Yuichiro Hashimoto

IPC: H01J49/16 ,  H01J49/04 ,  G01N30/72

CPC classification number: H01J49/167 ,  G01N30/7266 ,  H01J49/0445 ,  H01J49/0477

Abstract: An object of the present invention is to improve the safety and stability of an ion source by making a temperature distribution of a heated gas uniform while ensuring heat insulating properties. The ion source according to the present invention includes a gas introduction port inside a probe holder that holds an ion probe. A heater that increases the temperature of a heated gas and the gas introduction port are connected by a plurality of pipes which extend along an extending direction of the ion probe and are independent of each other (see FIG. 4).

公开(公告)号：US20250146985A1

公开(公告)日：2025-05-08

申请号：US18691091

申请日：2022-09-21

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Yuka Sugawara ,  Hiroyuki Yasuda ,  Riku Tamura ,  Tsugunao Toma ,  Yuichiro Hashimoto ,  Masuyuki Sugiyama

IPC: G01N30/72 ,  B01D15/16 ,  B01D15/42 ,  G01N30/02 ,  G01N30/86

Abstract: To provide a method for controlling a liquid chromatograph mass spectrometer by which contamination of a mobile phase solvent caused by a foreign substance can be detected without using an internal standard substance. The method for controlling a liquid chromatograph mass spectrometer according to the present disclosure includes: calculating a first ratio of signal intensities at a first time point and a second time point when measurement is performed using a first mobile phase solvent; calculating a second ratio of signal intensities at the first time point and the second time point when measurement is further performed using a second mobile phase solvent; and determining whether or not the second mobile phase solvent is contaminated according to an absolute difference between the first ratio and the second ratio.

公开(公告)号：US12153026B2

公开(公告)日：2024-11-26

申请号：US17911469

申请日：2021-03-05

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Daisuke Akieda ,  Nobuhiro Tsukada ,  Yusuke Yota ,  Yuichiro Hashimoto ,  Jun Maeda

IPC: G01N30/32 ,  G01N30/34

Abstract: The present invention relates to a liquid feeding apparatus capable of feeding a liquid with high accuracy. The liquid feeding apparatus includes a liquid feeder having a downstream side, a plunger, and a cylinder that is configured for aspirating and discharging a solvent when a plunger slides. The liquid feeding apparatus further includes a pressure sensor for the solvent to be discharged, a selector valve configured to switch between a plurality of solvents to be aspirated and discharged, and a controller configured to control the liquid feeder and the selector valve. The controller controls the selector valve in synchronization with an aspiration operation of the plunger so that a mixing ratio of the solvents changes, controls the plunger to cause the plunger to operate at first and second accelerations that are different from each other, and suppresses a fluctuation of the solvent to be aspirated by the plunger.

公开(公告)号：US12106951B2

公开(公告)日：2024-10-01

申请号：US17599231

申请日：2020-03-12

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Yuka Sumigama ,  Yuichiro Hashimoto ,  Hiroyuki Yasuda ,  Masuyuki Sugiyama

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/10

CPC classification number: H01J49/0036 ,  G01N27/62 ,  H01J49/0009 ,  H01J49/10

Abstract: Provided is a technique for accurately determining a performance of a single detector that detects ions having passed through a mass analysis unit. A mass analysis system according to the present disclosure includes, in a mass analysis device, a first converter configured to calculate a first measured value based on an intensity and an area of a pulse in an electric signal output from the detector configured to detect the ions having passed through the mass analysis unit, a second converter configured to obtain a second measured value by counting the number of pulses of the electric signal, a calculation unit configured to calculate an A/P ratio indicating a ratio of the first measured value to the second measured value, a determination unit configured to determine a performance of the detector based on a value of the A/P ratio, and a control unit configured to control at least an output of a determination result obtained by the determination unit.

公开(公告)号：US20240192180A1

公开(公告)日：2024-06-13

申请号：US18554237

申请日：2022-02-04

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Midori Tobita ,  Daisuke Akieda ,  Makoto Nogami ,  Yuichiro Hashimoto

IPC: G01N30/32 ,  G01N30/02 ,  G01N30/38 ,  G01N30/46 ,  G01N30/88

CPC classification number: G01N30/32 ,  G01N30/468 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/328 ,  G01N2030/385 ,  G01N2030/8804

Abstract: An automatic analyzer includes a liquid feed unit including a liquid feed unit and a liquid feed flow passage and feeding a mobile phase, a sample introduction unit introducing a sample to the mobile phase, a separation column separating the sample into plural components, a detector detecting the component, and a control unit. A pressure sensor detecting pressure of the liquid feed flow passage is provided, and the control unit calculates a pressure rise rate of the time immediately after starting liquid feeding of the mobile phase based on the pressure detected by the pressure sensor and a compression pressure variation amount and a pressure average after continuing liquid feeding of the mobile phase for a certain time, and determines completion of equilibration of the separation column.