公开(公告)号：US11530220B2

公开(公告)日：2022-12-20

申请号：US16967100

申请日：2019-02-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Hilary Plake Beck ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: A61K31/4985 ,  C07D487/04 ,  A61K45/06

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formula: wherein the letters and symbols a, b, c, d, e, f, A, R1, X1, Ar1 and Ar2 have the meanings provided in the specification.

公开(公告)号：US12258354B2

公开(公告)日：2025-03-25

申请号：US17853647

申请日：2022-06-29

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D519/00 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04 ,  C07D513/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US10815250B2

公开(公告)日：2020-10-27

申请号：US16268444

申请日：2019-02-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  C07D498/04 ,  A61P35/00 ,  C07D491/107 ,  C07D513/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US11407764B2

公开(公告)日：2022-08-09

申请号：US17023980

申请日：2020-09-17

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D498/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US11584755B2

公开(公告)日：2023-02-21

申请号：US16648865

申请日：2018-09-25

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Hilary Plake Beck ,  Leah Brigit Cleary ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  Luis Ruben P. Martinez ,  James Clifford Sutton, Jr.

IPC: C07D495/04 ,  A61P35/00 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/519 ,  C07D519/00

Abstract: Compounds are provided having Formula (I): wherein R, R1, Cyc and A have the meanings provided herein. The compounds have utility in the treatment of diseases, either alone or in combination with other agents.

公开(公告)号：US11548867B2

公开(公告)日：2023-01-10

申请号：US16631738

申请日：2018-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  Alice Chen Rico ,  James Clifford Sutton, Jr.

IPC: C07D401/12 ,  C07D215/12 ,  C07D217/18 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.