公开(公告)号：US12258354B2

公开(公告)日：2025-03-25

申请号：US17853647

申请日：2022-06-29

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D519/00 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04 ,  C07D513/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US10815250B2

公开(公告)日：2020-10-27

申请号：US16268444

申请日：2019-02-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  C07D498/04 ,  A61P35/00 ,  C07D491/107 ,  C07D513/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US12115163B2

公开(公告)日：2024-10-15

申请号：US18405638

申请日：2024-01-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Michael Patrick Dillon ,  Claire L. Neilan ,  Marcus Michael Fischer ,  Kimberline Yang Gerrick

IPC: A61K31/519 ,  A61K31/502 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K31/502 ,  A61P35/00

Abstract: Provided herein is a combination product comprising a methionine adenosyltransferase II alpha (MAT2A) inhibitor and a Type II protein arginine methyltransferase (Type II PRMT) inhibitor. The combination product is useful for the treatment of a variety of cancers, including solid tumors. The combination product is useful for the treatment of any number of MAT2A-associated and/or PRMT-associated diseases.

公开(公告)号：US12269820B2

公开(公告)日：2025-04-08

申请号：US18188278

申请日：2023-03-22

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Paul A. Barsanti ,  Michael Patrick Dillon ,  Firoz Ali Jaipuri ,  Ying-Zi Xu ,  Xin Linghu

IPC: C07D417/14 ,  A61P35/00

Abstract: Provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors. Additional utilities and advantages are described herein.

公开(公告)号：US11407764B2

公开(公告)日：2022-08-09

申请号：US17023980

申请日：2020-09-17

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D498/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US11584755B2

公开(公告)日：2023-02-21

申请号：US16648865

申请日：2018-09-25

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Hilary Plake Beck ,  Leah Brigit Cleary ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  Luis Ruben P. Martinez ,  James Clifford Sutton, Jr.

IPC: C07D495/04 ,  A61P35/00 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/519 ,  C07D519/00

Abstract: Compounds are provided having Formula (I): wherein R, R1, Cyc and A have the meanings provided herein. The compounds have utility in the treatment of diseases, either alone or in combination with other agents.

公开(公告)号：US11548867B2

公开(公告)日：2023-01-10

申请号：US16631738

申请日：2018-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  Alice Chen Rico ,  James Clifford Sutton, Jr.

IPC: C07D401/12 ,  C07D215/12 ,  C07D217/18 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

公开(公告)号：US20220389003A1

公开(公告)日：2022-12-08

申请号：US17761935

申请日：2020-09-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： James Clifford SUTTON, Jr. ,  Michael Patrick Dillon

IPC: C07D417/14 ,  C07D417/04

Abstract: Provided herein are compounds having the formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, Ar, X1, X2, and ring B have the meanings as provided herein. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors.