公开(公告)号：US11548867B2

公开(公告)日：2023-01-10

申请号：US16631738

申请日：2018-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  Alice Chen Rico ,  James Clifford Sutton, Jr.

IPC: C07D401/12 ,  C07D215/12 ,  C07D217/18 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

公开(公告)号：US11046691B1

公开(公告)日：2021-06-29

申请号：US17175578

申请日：2021-02-12

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Leah Cleary ,  Melissa Fleury ,  Zhonghua Pei ,  Richard Steel ,  James Sutton ,  John E. Knox ,  Zachary E. R. Newby

IPC: C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D239/95 ,  C07D471/04 ,  C07D405/12 ,  C07D403/12 ,  C07D403/14 ,  C07D487/04 ,  C07D401/14 ,  C07D401/12 ,  C07D413/12 ,  C07D519/00 ,  C07D417/12 ,  C07D239/80

Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US12258354B2

公开(公告)日：2025-03-25

申请号：US17853647

申请日：2022-06-29

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D519/00 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04 ,  C07D513/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US10815250B2

公开(公告)日：2020-10-27

申请号：US16268444

申请日：2019-02-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  C07D498/04 ,  A61P35/00 ,  C07D491/107 ,  C07D513/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US11407764B2

公开(公告)日：2022-08-09

申请号：US17023980

申请日：2020-09-17

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  James Clifford Sutton, Jr.

IPC: C07D498/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US11130759B1

公开(公告)日：2021-09-28

申请号：US17175581

申请日：2021-02-12

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Leah Cleary ,  Melissa Fleury ,  Zhonghua Pei ,  Richard Steel ,  James Sutton ,  John E. Knox ,  Zachary E. R. Newby

IPC: C07D471/04

Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US11084798B1

公开(公告)日：2021-08-10

申请号：US17175579

申请日：2021-02-12

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Leah Cleary ,  Melissa Fleury ,  Zhonghua Pei ,  Richard Steel ,  James Sutton ,  John E. Knox ,  Zachary E. R. Newby

IPC: C07D239/95 ,  C07D401/12 ,  C07D471/04 ,  C07D473/04 ,  C07D403/12 ,  C07D417/04 ,  C07D403/06 ,  C07D401/02 ,  C07D239/80

Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.