公开(公告)号：US11141725B2

公开(公告)日：2021-10-12

申请号：US15769665

申请日：2016-10-21

Applicant: IDEXX Laboratories, Inc.

Inventor： Garland Christian Misener ,  Richard Ellis Holt ,  Keith Nassif

IPC: B01L3/00 ,  G01N33/487 ,  G02B21/34 ,  B01L9/00

Abstract: A hematology test slide has the same or similar dimensions as a chemical reagent test slide and an immunoassay test slide so that it may be used with these other slides on a single clinical instrument. The hematology slide includes, in order from top to bottom, a slide housing having a top housing member, a top cover slip, a U-shaped, transfer tape spacer, a bottom cover slip, a base gasket and a base plate. The U-shaped spacer has a curved end portion which defines a sample deposit area, where a blood sample is pipetted thereon, and a pair of straight, parallel, spaced apart legs extending from the curved end portion. The legs define a read area. A blood sample deposited on the hematology slide at the sample deposit area will flow by capillary action to the read area, where optical measurements are made on the sample.

公开(公告)号：US11047857B2

公开(公告)日：2021-06-29

申请号：US15908313

申请日：2018-02-28

Applicant: IDEXX Laboratories, Inc.

Inventor： Eugene Chan ,  Keith Nassif

IPC: G01N33/573 ,  G01N33/543 ,  G01N35/00

Abstract: An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix. The slide cover piece has an opening formed through the thickness thereof to expose a central portion of the fluid flow matrix so that a precise volume of fluid sample of blood, serum or the like, preferably pre-mixed with a conjugate reagent, and precise volumes of a wash reagent and a substrate (detector reagent), may be deposited on the matrix through the cover opening by a metering device of the analytical instrument. The bottom piece of the immunoassay test slide is transparent, and the slide is moved by a transport mechanism of the analytical instrument over a reflectometer or a fluorometer for performing reflectance or fluorescence measurements.

公开(公告)号：US20180304257A1

公开(公告)日：2018-10-25

申请号：US15769665

申请日：2016-10-21

Applicant: IDEXX Laboratories, Inc.

Inventor： Garland Christian Misener ,  Richard Ellis Holt ,  Keith Nassif

IPC: B01L3/00 ,  B01L9/00 ,  G02B21/34

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L9/52 ,  B01L2300/0609 ,  B01L2300/0822 ,  B01L2300/168 ,  B01L2400/0406 ,  G01N33/4875 ,  G02B21/34

Abstract: A hematology test slide has the same or similar dimensions as a chemical reagent test slide and an immunoassay test slide so that it may be used with these other slides on a single clinical instrument. The hematology slide includes, in order from top to bottom, a slide housing having a top housing member, a top cover slip, a U-shaped, transfer tape spacer, a bottom cover slip, a base gasket and a base plate. The U-shaped spacer has a curved end portion which defines a sample deposit area, where a blood sample is pipetted thereon, and a pair of straight, parallel, spaced apart legs extending from the curved end portion. The legs define a read area. A blood sample deposited on the hematology slide at the sample deposit area will flow by capillary action to the read area, where optical measurements are made on the sample.

公开(公告)号：US20180188250A1

公开(公告)日：2018-07-05

申请号：US15908313

申请日：2018-02-28

Applicant: IDEXX Laboratories, Inc.

Inventor： Eugene Chan ,  Keith Nassif

IPC: G01N33/573 ,  G01N35/00 ,  G01N33/543

CPC classification number: G01N33/573 ,  G01N33/54366 ,  G01N35/00029 ,  G01N2035/00138 ,  G01N2333/918

Abstract: An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix. The slide cover piece has an opening formed through the thickness thereof to expose a central portion of the fluid flow matrix so that a precise volume of fluid sample of blood, serum or the like, preferably pre-mixed with a conjugate reagent, and precise volumes of a wash reagent and a substrate (detector reagent), may be deposited on the matrix through the cover opening by a metering device of the analytical instrument. The bottom piece of the immunoassay test slide is transparent, and the slide is moved by a transport mechanism of the analytical instrument over a reflectometer or a fluorometer for performing reflectance or fluorescence measurements.

公开(公告)号：US11666909B2

公开(公告)日：2023-06-06

申请号：US17469215

申请日：2021-09-08

Applicant: IDEXX Laboratories, Inc.

Inventor： Garland Christian Misener ,  Richard Ellis Holt ,  Keith Nassif

IPC: B01L3/00 ,  G02B21/34 ,  B01L9/00 ,  G01N33/487

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L9/52 ,  G02B21/34 ,  B01L2300/0609 ,  B01L2300/0822 ,  B01L2300/168 ,  B01L2400/0406 ,  G01N33/4875

Abstract: A hematology test slide has the same or similar dimensions as a chemical reagent test slide and an immunoassay test slide so that it may be used with these other slides on a single clinical instrument. The hematology slide includes, in order from top to bottom, a slide housing having a top housing member, a top cover slip, a U-shaped, transfer tape spacer, a bottom cover slip, a base gasket and a base plate. The U-shaped spacer has a curved end portion which defines a sample deposit area, where a blood sample is pipetted thereon, and a pair of straight, parallel, spaced apart legs extending from the curved end portion. The legs define a read area. A blood sample deposited on the hematology slide at the sample deposit area will flow by capillary action to the read area, where optical measurements are made on the sample.

公开(公告)号：US20210402400A1

公开(公告)日：2021-12-30

申请号：US17469215

申请日：2021-09-08

Applicant: IDEXX Laboratories, Inc.

Inventor： Garland Christian Misener ,  Richard Ellis Holt ,  Keith Nassif

IPC: B01L3/00 ,  G02B21/34 ,  B01L9/00

Abstract: A hematology test slide has the same or similar dimensions as a chemical reagent test slide and an immunoassay test slide so that it may be used with these other slides on a single clinical instrument. The hematology slide includes, in order from top to bottom, a slide housing having a top housing member, a top cover slip, a U-shaped, transfer tape spacer, a bottom cover slip, a base gasket and a base plate. The U-shaped spacer has a curved end portion which defines a sample deposit area, where a blood sample is pipetted thereon, and a pair of straight, parallel, spaced apart legs extending from the curved end portion. The legs define a read area. A blood sample deposited on the hematology slide at the sample deposit area will flow by capillary action to the read area, where optical measurements are made on the sample.

公开(公告)号：US09933428B2

公开(公告)日：2018-04-03

申请号：US14358280

申请日：2013-01-07

Applicant: IDEXX Laboratories, Inc.

Inventor： Eugene Chan ,  Keith Nassif

IPC: G01N33/557 ,  G01N33/573 ,  G01N35/00 ,  G01N33/543

CPC classification number: G01N33/573 ,  G01N33/54366 ,  G01N35/00029 ,  G01N2035/00138 ,  G01N2333/918

Abstract: An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix. The slide cover piece has an opening formed through the thickness thereof to expose a central portion of the fluid flow matrix so that a precise volume of fluid sample of blood, serum or the like, preferably pre-mixed with a conjugate reagent, and precise volumes of a wash reagent and a substrate (detector reagent), may be deposited on the matrix through the cover opening by a metering device of the analytical instrument. The bottom piece of the immunoassay test slide is transparent, and the slide is moved by a transport mechanism of the analytical instrument over a reflectometer or a fluorometer for performing reflectance or fluorescence measurements.

公开(公告)号：US20140315216A1

公开(公告)日：2014-10-23

申请号：US14358280

申请日：2013-01-07

Applicant: IDEXX Laboratories, Inc.

Inventor： Eugene Chan ,  Keith Nassif

IPC: G01N33/573

CPC classification number: G01N33/573 ,  G01N33/54366 ,  G01N35/00029 ,  G01N2035/00138 ,  G01N2333/918

Abstract: An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix. The slide cover piece has an opening formed through the thickness thereof to expose a central portion of the fluid flow matrix so that a precise volume of fluid sample of blood, serum or the like, preferably pre-mixed with a conjugate reagent, and precise volumes of a wash reagent and a substrate (detector reagent), may be deposited on the matrix through the cover opening by a metering device of the analytical instrument. The bottom piece of the immunoassay test slide is transparent, and the slide is moved by a transport mechanism of the analytical instrument over a reflectometer or a fluorometer for performing reflectance or fluorescence measurements.

Abstract translation: 用于干化学分析仪器的免疫测定试验片包括由两个可配置部分形成的滑动壳体或壳体 - 滑动盖件和滑动底部件。 滑动壳体限定内部空腔，其中位于片状多孔载体矩阵中。 滑动盖件具有通过其厚度形成的开口，以暴露流体流动基体的中心部分，使得精确体积的血液，血清等的液体样品优选与共轭试剂预混合，并且精确体积 洗涤剂和底物（检测剂试剂）可以通过分析仪器的计量装置通过盖开口沉积在基质上。 免疫测定试验载玻片的底部是透明的，并且通过分析仪器的输送机构通过反射计或荧光计使载玻片移动，以进行反射或荧光测量。