公开(公告)号：US11428664B2

公开(公告)日：2022-08-30

申请号：US15509447

申请日：2015-09-07

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Vinay Kumar ,  Navakanta Bhat

IPC: G01N27/416 ,  G01N33/72

Abstract: An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.

公开(公告)号：US20200240942A1

公开(公告)日：2020-07-30

申请号：US16756743

申请日：2018-10-16

Applicant: Indian Institute of Science

Inventor： Chandra Shekhar Prajapati ,  Navakanta Bhat

IPC: G01N27/12

Abstract: Methods of fabrication and nano-sensor and nano-sensor array thereof are provided. A sensing electrode assembly can be patterned on a sacrificial layer of a substrate. The sensing electrode assembly can comprise a pair of contact pads and an electrode element coupled to and disposed between the pair of contact pads. The sensing electrode assembly can be formed on the patterned sensing electrode assembly. The sacrificial layer below a portion of the electrode element can be removed to obtain a suspended electrode element. The suspended electrode element can be oxidized at a first predetermined temperature to obtain a pair of electromigrated regions and a notch portion between the pair of the electromigrated regions. The notch portion can be used to detect a gaseous component in an ambient gas at a second predetermined temperature.

公开(公告)号：US11592437B2

公开(公告)日：2023-02-28

申请号：US16802179

申请日：2020-02-26

Applicant: Indian Institute of Science

Inventor： Pallavi Dasgupta ,  Patnam Krishnaswamy ,  Vinay Kumar ,  Navakanta Bhat

IPC: G01N33/487 ,  G01N27/327 ,  G01N27/333 ,  G01N33/49 ,  G01N33/493

Abstract: Methods and devices for quantifying creatinine in a test sample are provided. The test sample is contacted with a sensing composition to obtain a product comprising a hydantoin-transition metal complex and ammonia. The sensing composition comprises creatinine deaminase and a transition metal salt. The creatinine deaminase enzymatically reacts with creatinine to provide the N-methyl hydantoin and ammonia. The N-methyl hydantoin forms the hydantoin-transition metal complex with the transition salt. A potential difference is applied to the product to measure a current signal provided by the hydantoin-transition metal complex. Concentration of N-methyl hydantoin is obtained based on the measured current signal using a calibration equation. The concentration of N-methyl hydantoin is correlated with concentration of creatinine to quantify the creatinine in the test sample.

公开(公告)号：US11275043B2

公开(公告)日：2022-03-15

申请号：US16755344

申请日：2018-10-10

Applicant: Indian Institute of Science

Inventor： Chandra Shekhar Prajapati ,  Navakanta Bhat

IPC: G01N27/18

Abstract: Nano-sensors, nano-sensor array and methods of fabrication thereof are provided. A nano-sensor comprises a pair of sensing electrode assemblies aligned longitudinally along a first axis. Each sensing electrode assembly comprises an electrode strip coupled to a contact pad at a first end of the electrode strip. A sensing member is disposed between the pair of sensing electrode assemblies to detect, at a predetermined temperature, presence of a gaseous component. A thermally conductive layer is provided in contact with the sensing member. The nano-sensor comprises a heating assembly, comprising a heating strip disposed between and coupled to a pair of heating contact pads, aligned longitudinally along a second axis substantially perpendicular to the first axis. A portion of the heating strip is in contact with the thermally conductive layer to heat the sensing member through the thermally conductive layer.

公开(公告)号：US20190067440A1

公开(公告)日：2019-02-28

申请号：US16114650

申请日：2018-08-28

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Mayank Shrivastava ,  Sayak Dutta Gupta ,  Ankit Soni ,  Srinivasan Raghavan ,  Navakanta Bhat

IPC: H01L29/49 ,  H01L29/778 ,  H01L21/02

Abstract: The present disclosure provides an improved enhancement mode field effect transistor (FET) having an oxide (AlxTi1-xO) emulating p-type gate. The present disclosure provides a novel enhancement mode High Electron Mobility Transistor (HEMT) structure with AlxTi1-xO Gate Oxide Engineering as Replacement of p-GaN Gate. In an aspect, the present disclosure provides a hybrid gate stack that combines p-GaN technology with the proposed oxide for e-mode operation. The HEMT structure with AlxTi1-xO Gate oxide provides a threshold voltage tuning from negative to positive by changing p-doping composition. Using a developed p-type oxide, e-mode device shows ON current ˜400 mA/mm, sub-threshold slope of 73 mV/dec, Ron=8.9 Ωmm, interface trap density

公开(公告)号：US20170241945A1

公开(公告)日：2017-08-24

申请号：US15509447

申请日：2015-09-07

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Vinay Kumar ,  Navakanta Bhat

IPC: G01N27/416 ,  G01N33/72

CPC classification number: G01N27/4168 ,  A61B5/1477 ,  A61B5/726 ,  A61B2562/0295 ,  G01N33/721

Abstract: An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.

公开(公告)号：US12078605B2

公开(公告)日：2024-09-03

申请号：US16756743

申请日：2018-10-16

Applicant: Indian Institute of Science

Inventor： Chandra Shekhar Prajapati ,  Navakanta Bhat

IPC: G01N27/12 ,  B82Y15/00 ,  B82Y40/00

CPC classification number: G01N27/127 ,  B82Y15/00 ,  B82Y40/00

Abstract: Methods of fabrication and nano-sensor and nano-sensor array thereof are provided. A sensing electrode assembly can be patterned on a sacrificial layer of a substrate. The sensing electrode assembly can comprise a pair of contact pads and an electrode element coupled to and disposed between the pair of contact pads. The sensing electrode assembly can be formed on the patterned sensing electrode assembly. The sacrificial layer below a portion of the electrode element can be removed to obtain a suspended electrode element. The suspended electrode element can be oxidized at a first predetermined temperature to obtain a pair of electromigrated regions and a notch portion between the pair of the electromigrated regions. The notch portion can be used to detect a gaseous component in an ambient gas at a second predetermined temperature.

公开(公告)号：US11973137B2

公开(公告)日：2024-04-30

申请号：US17309583

申请日：2019-12-05

Applicant: Indian Institute of Science

Inventor： Srinivasan Raghavan ,  Navakanta Bhat ,  Rohith Soman

IPC: H01L29/778 ,  H01L29/06

CPC classification number: H01L29/7786 ,  H01L29/0638

Abstract: The present subject matter provides a High Mobility Electron Transistor (HEMT) comprising: a substrate, a nucleation layer provided on the substrate, a channel layer, and a buffer layer formed between the nucleation layer and the channel layer. The buffer layer comprises a vertical stack of p-n junctions. Each p-n junction of the vertical stack of p-n junctions comprises an n-type layer provided on a p-type layer. The n-type layer and the p-type layer are parallel to the substrate.

公开(公告)号：US11867654B2

公开(公告)日：2024-01-09

申请号：US15573686

申请日：2016-01-22

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Vinay Kumar ,  Navakanta Bhat ,  Nikhila Kashyap Dhanvantari Madhuresh

IPC: G01N27/327 ,  G01N33/543 ,  G01N33/493 ,  A61B5/145 ,  A61B5/1468 ,  G01N27/48 ,  G01N33/68 ,  G01N33/70

CPC classification number: G01N27/3277 ,  A61B5/1468 ,  A61B5/14507 ,  A61B5/14546 ,  G01N27/327 ,  G01N27/48 ,  G01N33/493 ,  G01N33/5438 ,  G01N33/68 ,  G01N33/70 ,  G01N2333/76 ,  G01N2333/765

Abstract: An electrochemically active, creatinine-binding device is provided to detect and measure quantitatively, creatinine in biological samples. The device of the present invention is also provided with a device to detect and measure quantitatively creatinine and albumin bioanalytes, simultaneously and to determine albumin to creatinine ratio (ACR). The present invention also provides an electrochemically active, creatinine-binding and albumin-binding device, for collection and retention of biological samples, having creatinine and albumin bioanalytes. In the present invention, a device holder is provided to receive the electrochemically active, creatinine-binding and albumin-binding device. The device, point-of-care biosensor and the method of the present invention, facilitate quantitative measurement of creatinine and albumin bioanalytes in urine and blood samples, and albumin to creatinine ratio (ACR), in urine samples, electrochemically, by determining redox current values.

公开(公告)号：US11435344B2

公开(公告)日：2022-09-06

申请号：US15509460

申请日：2015-09-01

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Vinay Kumar ,  Navakanta Bhat

IPC: G01N33/68 ,  G01N27/327 ,  G01N33/543

Abstract: An electrochemically active device for collecting and retaining a biological sample with a bioanalyte, the device provided with at least a two-electrode member and an albumin-binding and an electrochemically active receptor in chemical contact with the two-electrode members and the biological sample. The present invention also provides a point-of-care biosensor with the device of the present invention and a method for measuring a bioanalyte in a biological sample. The device, point-of-care biosensor and the method of the present invention facilitate accurate measurements concentrations of urine albumin, human serum albumin (HSA), glycated albumin (GA) and methemalbumin (MHA) by determining redox current values in reduced volumes of biological samples.