公开(公告)号：US20200072850A1

公开(公告)日：2020-03-05

申请号：US16467229

申请日：2017-12-08

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Raghavan Varadarajan ,  Tariq Ahmad Najar ,  Rohini Datta

IPC: G01N33/68 ,  C12N15/10 ,  C40B40/02

Abstract: The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.

公开(公告)号：US20230233664A1

公开(公告)日：2023-07-27

申请号：US18158940

申请日：2023-01-24

Applicant: Emory University ,  Indian Institute of Science

Inventor： Rama Rao Amara ,  Andrew Jones ,  Raghavan Varadarajan

IPC: A61K39/21 ,  C07K14/16 ,  C12N7/00

CPC classification number: A61K39/21 ,  C07K14/162 ,  C12N7/00 ,  A61K2039/53

Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.

公开(公告)号：US11221339B2

公开(公告)日：2022-01-11

申请号：US16467229

申请日：2017-12-08

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Raghavan Varadarajan ,  Tariq Ahmad Najar ,  Rohini Datta

IPC: C40B30/04 ,  G01N33/68 ,  C12N15/10 ,  C40B40/02

Abstract: The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.

公开(公告)号：US20200368348A1

公开(公告)日：2020-11-26

申请号：US16966387

申请日：2019-01-31

Applicant: Emory University ,  Indian Institute of Science

Inventor： Rama Rao Amara ,  Andrew Jones ,  Raghavan Varadarajan

IPC: A61K39/21 ,  C07K14/16 ,  C12N7/00

Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.

公开(公告)号：US12194088B2

公开(公告)日：2025-01-14

申请号：US18158940

申请日：2023-01-24

Applicant: Emory University ,  Indian Institute of Science

Inventor： Rama Rao Amara ,  Andrew Jones ,  Raghavan Varadarajan

IPC: A61K39/12 ,  A61K39/21 ,  C07K14/155 ,  C07K14/16 ,  C12N7/00 ,  A61K39/00

Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.

公开(公告)号：US11590219B2

公开(公告)日：2023-02-28

申请号：US16966387

申请日：2019-01-31

Applicant: Emory University ,  Indian Institute of Science

Inventor： Rama Rao Amara ,  Andrew Jones ,  Raghavan Varadarajan

IPC: A61K39/21 ,  C12N7/00 ,  C07K14/16 ,  A61K39/00

Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.

公开(公告)号：US10344058B2

公开(公告)日：2019-07-09

申请号：US15305575

申请日：2015-04-29

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Raghavan Varadarajan ,  Vamsee V. Aditya Mallajosyula

IPC: C07K14/005 ,  A61K39/145

Abstract: The present disclosure relates to a polypeptide comprising hemagglutinin stem domain fragments that can elicit broadly cross-reactive anti-influenza antibodies and confer protection against influenza virus. The disclosure also provides a method of preparing the polypeptide with biochemical and biophysical properties that enhance its immunogenic properties. Also provided are recombinant DNA constructs, vectors, and host cells comprising the nucleic acid encoding the polypeptide, as well as uses of the polypeptide, particularly in the prevention, and detection of influenza.