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    Device and method for detection of haemoglobin and its complexes
    1.
    发明授权
    Device and method for detection of haemoglobin and its complexes 有权

    公开(公告)号：US11428664B2

    公开(公告)日：2022-08-30

    申请号：US15509447

    申请日：2015-09-07

    Applicant: INDIAN INSTITUTE OF SCIENCE

    Inventor： Vinay Kumar ,  Navakanta Bhat

    IPC: G01N27/416 ,  G01N33/72

    Abstract: An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.

    Electrochemical measurement of creatinine in serum
    3.
    发明授权
    Electrochemical measurement of creatinine in serum 有权

    公开(公告)号：US11592437B2

    公开(公告)日：2023-02-28

    申请号：US16802179

    申请日：2020-02-26

    Applicant: Indian Institute of Science

    Inventor： Pallavi Dasgupta ,  Patnam Krishnaswamy ,  Vinay Kumar ,  Navakanta Bhat

    IPC: G01N33/487 ,  G01N27/327 ,  G01N27/333 ,  G01N33/49 ,  G01N33/493

    Abstract: Methods and devices for quantifying creatinine in a test sample are provided. The test sample is contacted with a sensing composition to obtain a product comprising a hydantoin-transition metal complex and ammonia. The sensing composition comprises creatinine deaminase and a transition metal salt. The creatinine deaminase enzymatically reacts with creatinine to provide the N-methyl hydantoin and ammonia. The N-methyl hydantoin forms the hydantoin-transition metal complex with the transition salt. A potential difference is applied to the product to measure a current signal provided by the hydantoin-transition metal complex. Concentration of N-methyl hydantoin is obtained based on the measured current signal using a calibration equation. The concentration of N-methyl hydantoin is correlated with concentration of creatinine to quantify the creatinine in the test sample.

    DEVICE AND METHOD FOR DETECTION OF HAEMOGLOBIN AND ITS COMPLEXES
    4.
    发明申请
    DEVICE AND METHOD FOR DETECTION OF HAEMOGLOBIN AND ITS COMPLEXES 审中-公开

    公开(公告)号：US20170241945A1

    公开(公告)日：2017-08-24

    申请号：US15509447

    申请日：2015-09-07

    Applicant: INDIAN INSTITUTE OF SCIENCE

    Inventor： Vinay Kumar ,  Navakanta Bhat

    IPC: G01N27/416 ,  G01N33/72

    CPC classification number: G01N27/4168 ,  A61B5/1477 ,  A61B5/726 ,  A61B2562/0295 ,  G01N33/721

    Abstract: An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.

    Electrochemical biosensor and a method of sensing albumin and its complexes
    6.
    发明授权
    Electrochemical biosensor and a method of sensing albumin and its complexes 有权

    公开(公告)号：US11435344B2

    公开(公告)日：2022-09-06

    申请号：US15509460

    申请日：2015-09-01

    Applicant: INDIAN INSTITUTE OF SCIENCE

    Inventor： Vinay Kumar ,  Navakanta Bhat

    IPC: G01N33/68 ,  G01N27/327 ,  G01N33/543

    Abstract: An electrochemically active device for collecting and retaining a biological sample with a bioanalyte, the device provided with at least a two-electrode member and an albumin-binding and an electrochemically active receptor in chemical contact with the two-electrode members and the biological sample. The present invention also provides a point-of-care biosensor with the device of the present invention and a method for measuring a bioanalyte in a biological sample. The device, point-of-care biosensor and the method of the present invention facilitate accurate measurements concentrations of urine albumin, human serum albumin (HSA), glycated albumin (GA) and methemalbumin (MHA) by determining redox current values in reduced volumes of biological samples.

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