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公开(公告)号：US11231409B2
公开(公告)日：2022-01-25
申请号：US16591413
申请日：2019-10-02
Applicant: Instrumentation Laboratory Company
Inventor： Brian Joseph Bosy , Josef Kerimo
Abstract: An apparatus for measuring hemolysis in a cartridge based automated blood analyzer is described. The apparatus allows hemolysis testing to be performed on a sample which is presented as a whole blood sample for other testing by the cartridge based automated blood analyzer. A disposable module is configured for optically analyzing one or more plasma analytes in a flow cell while red blood cells are acoustically separated from plasma in the flow cell.
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公开(公告)号：US11079325B2
公开(公告)日：2021-08-03
申请号：US14696756
申请日：2015-04-27
Applicant: Instrumentation Laboratory Company
Inventor： Josef Kerimo , Hansong Zeng , Ron Scharlack , Gert Blankenstein
Abstract: This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.
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公开(公告)号：US10324025B2
公开(公告)日：2019-06-18
申请号：US15971061
申请日：2018-05-04
Applicant: Instrumentation Laboratory Company
Inventor： Brian Joseph Bosy , Josef Kerimo
Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member made from an optically clear material and a second plate member made from an optically clear material and opposing the first plate member. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal. The floating seal surrounds a fluid chamber that retains a sample of body fluid for optical measurement. The fluid chamber may be opened for flushing by separating the first plate member from the second plate member. During measurements the fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member.
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公开(公告)号：US10288556B2
公开(公告)日：2019-05-14
申请号：US15694083
申请日：2017-09-01
Applicant: Instrumentation Laboratory Company
Inventor： Brian Joseph Bosy , Josef Kerimo
Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.
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公开(公告)号：US20180252633A1
公开(公告)日：2018-09-06
申请号：US15971061
申请日：2018-05-04
Applicant: Instrumentation Laboratory Company
Inventor： Brian Joseph Bosy , Josef Kerimo
CPC classification number: G01N21/05 , B01L3/508 , B01L2200/0689 , B01L2300/0822 , G01N21/0303 , G01N21/27 , G01N33/4915 , G01N2021/058 , G01N2021/115 , G01N2201/061 , G01N2201/062 , G01N2201/0668
Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member made from an optically clear material and a second plate member made from an optically clear material and opposing the first plate member. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal. The floating seal surrounds a fluid chamber that retains a sample of body fluid for optical measurement. The fluid chamber may be opened for flushing by separating the first plate member from the second plate member. During measurements the fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member.
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Patent Agency Ranking
公开(公告)号：US20170363538A1
公开(公告)日：2017-12-21
申请号：US15694083
申请日：2017-09-01
Applicant: Instrumentation Laboratory Company
Inventor： Brian Joseph Bosy , Josef Kerimo
CPC classification number: G01N21/31 , B01L3/508 , B01L2200/025 , B01L2200/0689 , B01L2300/0822 , B01L2300/0877 , G01N21/0303 , G01N21/05 , G01N33/4915 , G01N2021/058 , G01N2021/115 , G01N2201/0668
Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.
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公开(公告)号：US20170336385A1
公开(公告)日：2017-11-23
申请号：US15594827
申请日：2017-05-15
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Gert Blankenstein , Josef Kerimo , Hansong Zeng
CPC classification number: G01N33/49 , B01L3/502 , B01L2300/0654 , B01L2300/168 , G01N21/0303 , G01N21/05 , G01N21/25 , G01N21/552 , G01N2201/0612
Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.
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公开(公告)号：US20220113297A1
公开(公告)日：2022-04-14
申请号：US17558721
申请日：2021-12-22
Applicant: Instrumentation Laboratory Company
Inventor： Brian Joseph Bosy , Josef Kerimo
Abstract: An apparatus for measuring hemolysis in a cartridge based automated blood analyzer is described. The apparatus allows hemolysis testing to be performed on a sample which is presented as a whole blood sample for other testing by the cartridge based automated blood analyzer. A disposable module is configured for optically analyzing one or more plasma analytes in a flow cell while red blood cells are acoustically separated from plasma in the flow cell.
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公开(公告)号：US20220018765A1
公开(公告)日：2022-01-20
申请号：US17360477
申请日：2021-06-28
Applicant: Instrumentation Laboratory Company
Inventor： Josef Kerimo , Hansong Zeng , Ron Scharlack , Gert Blankenstein
Abstract: This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.
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公开(公告)号：US20190293551A1
公开(公告)日：2019-09-26
申请号：US16388498
申请日：2019-04-18
Applicant: Instrumentation Laboratory Company
Inventor： Brian Joseph Bosy , Josef Kerimo
Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.
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