公开(公告)号：US11079325B2

公开(公告)日：2021-08-03

申请号：US14696756

申请日：2015-04-27

Applicant: Instrumentation Laboratory Company

Inventor： Josef Kerimo ,  Hansong Zeng ,  Ron Scharlack ,  Gert Blankenstein

IPC: G01N21/53 ,  G01N21/64 ,  G01N21/65 ,  G01N33/49 ,  G01N21/59

Abstract: This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.

公开(公告)号：US20220018765A1

公开(公告)日：2022-01-20

申请号：US17360477

申请日：2021-06-28

Applicant: Instrumentation Laboratory Company

Inventor： Josef Kerimo ,  Hansong Zeng ,  Ron Scharlack ,  Gert Blankenstein

IPC: G01N21/53 ,  G01N21/64 ,  G01N21/65 ,  G01N33/49 ,  G01N21/59

Abstract: This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.