公开(公告)号：US20180289639A1

公开(公告)日：2018-10-11

申请号：US16007998

申请日：2018-06-13

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61P37/08 ,  A61K9/00 ,  A61K9/12

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.

公开(公告)号：US10441538B2

公开(公告)日：2019-10-15

申请号：US15876553

申请日：2018-01-22

Applicant: Insys Development Company, Inc.

Inventor： Kiran Amancha ,  Chandeshwari Chilampalli ,  Thrimoorthy Potta ,  Ningxin Yan ,  Venkat R. Goskonda ,  Eshwaran Narayanan

IPC: A61K31/485 ,  A61K47/10 ,  A61K47/12 ,  A61K9/08 ,  A61P25/36 ,  A61K9/00

Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid overdose, opioid dependence, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention intranasally to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally the naloxone formulations of the present invention.

公开(公告)号：US20190216750A1

公开(公告)日：2019-07-18

申请号：US16290853

申请日：2019-03-01

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K31/137 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61P37/08

CPC classification number: A61K31/137 ,  A61K9/0043 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/186 ,  A61P37/08

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.

公开(公告)号：US20180289617A1

公开(公告)日：2018-10-11

申请号：US16007999

申请日：2018-06-13

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K9/00 ,  A61K9/08 ,  A61K31/137 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61P11/02

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.

公开(公告)号：US10039710B2

公开(公告)日：2018-08-07

申请号：US15488712

申请日：2017-04-17

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K9/00 ,  A61K31/137 ,  A61K47/36 ,  A61K47/10 ,  A61K47/02 ,  A61K47/12

CPC classification number: A61K9/0043 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/0078 ,  A61K9/08 ,  A61K31/137 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.

公开(公告)号：US20180147143A1

公开(公告)日：2018-05-31

申请号：US15876553

申请日：2018-01-22

Applicant: Insys Development Company, Inc.

Inventor： Kiran Amancha ,  Chandeshwari Chilampalli ,  Thrimoorthy Potta ,  Ningxin Yan ,  Venkat R. Goskonda

IPC: A61K9/08 ,  A61K31/485 ,  A61K9/00 ,  A61K47/10 ,  A61K47/12 ,  A61P25/36

CPC classification number: A61K9/08 ,  A61K9/0043 ,  A61K31/485 ,  A61K47/10 ,  A61K47/12 ,  A61P25/36

Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid overdose, opioid dependence, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention intranasally to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally the naloxone formulations of the present invention.

公开(公告)号：US20190209494A1

公开(公告)日：2019-07-11

申请号：US16242101

申请日：2019-01-08

Applicant: Insys Development Company, Inc.

Inventor： Eshwaran Narayanan ,  Rajesh Wakaskar ,  Chandeshwari Chilampalli ,  Thrimoorthy Potta ,  Venkat R. Goskonda

IPC: A61K31/137 ,  A61K47/02 ,  A61K47/18 ,  A61K47/10 ,  A61K9/00 ,  A61J1/00

CPC classification number: A61K31/137 ,  A61J1/00 ,  A61K9/0043 ,  A61K47/02 ,  A61K47/10 ,  A61K47/186

Abstract: The present invention is directed to methods of stabilizing a pharmaceutical composition comprising epinephrine containing the steps filling a container, capping the container, assembling the container and placing the assembled capped container (assembled device) in a secondary packaging system.

公开(公告)号：US10966925B2

公开(公告)日：2021-04-06

申请号：US16240632

申请日：2019-01-04

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K9/08 ,  A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61K9/12 ,  A61K9/00 ,  A61P37/08 ,  A61K47/26 ,  A61K47/10 ,  A61K47/18 ,  A61M11/00

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.

公开(公告)号：US20190070105A1

公开(公告)日：2019-03-07

申请号：US16177361

申请日：2018-10-31

Applicant: Insys Development Company, Inc.

Inventor： Kiran Amancha ,  Chandeshwari Chilampalli ,  Thrimoorthy Potta ,  Ningxin Yan ,  Venkat R. Goskonda

IPC: A61K9/00 ,  A61K31/485

Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid overdose, opioid dependence, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention intranasally to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally the naloxone formulations of the present invention.

公开(公告)号：US20180318215A1

公开(公告)日：2018-11-08

申请号：US16023313

申请日：2018-06-29

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K9/08 ,  A61K31/137 ,  A61K47/02 ,  A61K47/18 ,  A61K47/10 ,  A61K9/00 ,  A61P37/08

CPC classification number: A61K31/137 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/08 ,  A61K9/12 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/186 ,  A61P37/08

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.