公开(公告)号：US10705087B2

公开(公告)日：2020-07-07

申请号：US14907689

申请日：2014-07-25

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Kengo Takeuchi ,  Yuki Togashi ,  Seiji Sakata ,  Satoko Baba

IPC: C12Q1/68 ,  G01N33/574 ,  C12Q1/6886 ,  G01N33/50 ,  A61K31/277 ,  A61K31/553

Abstract: A polynucleotide, which is a novel causative gene for cancer, is elucidated, and, based on this finding, provided are a method for detecting the polynucleotide, or a polypeptide encoded by the polynucleotide; a kit and a primer set for the detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for treating a cancer containing the inhibitor. In the detection method of the present invention, an NTRK3 fusion protein, or a fusion gene encoding the fusion protein, or an ETV6 fusion protein, or a fusion gene encoding the fusion protein, in a sample derived from the digestive system obtained from a subject, is detected.