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    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
    2.
    发明授权
    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease 失效
    丝氨酸蛋白酶抑制剂，特别是HCV NS3-NS4A蛋白酶

    公开(公告)号：US07365092B2

    公开(公告)日：2008-04-29

    申请号：US10821663

    申请日：2004-04-09

    Applicant: Kevin M. Cottrell ,  John Maxwell ,  Robert B. Perni ,  Janos Pitlik

    Inventor： Kevin M. Cottrell ,  John Maxwell ,  Robert B. Perni ,  Janos Pitlik

    IPC: A61K31/4025 ,  C07D207/30

    CPC classification number: C07K5/0804 ,  A61K31/40 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.

    Abstract translation: 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐。 因此，它们通过干扰丙型肝炎病毒的生命周期起作用，并且作为抗病毒剂是有用的。 本发明还涉及包含用于离体使用或用于给予HCV感染患者的所述化合物的药学上可接受的组合物以及制备该化合物的方法。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗患者HCV感染的方法。

    Integral molded heat sinks on DC-DC converters and power supplies
    4.
    发明申请
    Integral molded heat sinks on DC-DC converters and power supplies 有权
    DC-DC转换器和电源的集成模制散热器

    公开(公告)号：US20060164811A1

    公开(公告)日：2006-07-27

    申请号：US11044870

    申请日：2005-01-26

    Applicant: John Maxwell ,  William Yeates

    Inventor： John Maxwell ,  William Yeates

    IPC: H05K7/20

    CPC classification number: H05K1/0203 ,  H05K1/0204 ,  H05K3/284 ,  H05K3/285 ,  H05K7/209 ,  H05K2201/0141 ,  H05K2201/066 ,  H05K2203/1316

    Abstract: A power supply module has a printed circuit board (PCB) containing a plurality of electrical components for converting an input voltage to an output voltage. A heat sink is formed over substantially an entire surface area of the PCB for providing heat dissipation. The heat sink is made with a thermally conductive and electrically insulating polymer compound, such as liquid crystalline polymer or polyphenylene sulfide, which is injection molded to surface of the PCB. The heat sink can be formed on a front side and backside of the PCB and may have a plurality of posts for increasing the heat dissipating surface area of the heat sink. By disposing the heat sink over substantially the entire surface of the PCB, the heat sink is able to remove more heat and allow the power supply module to provide more output load current given the same physical size and ambient conditions.

    Abstract translation: 电源模块具有包含用于将输入电压转换为输出电压的多个电气部件的印刷电路板（PCB）。 在PCB的基本上整个表面区域上形成散热器以提供散热。 散热器由注塑在PCB表面上的导热和电绝缘的聚合物化合物（例如液晶聚合物或聚苯硫醚）制成。 散热器可以形成在PCB的前侧和后侧，并且可以具有用于增加散热片的散热表面积的多个支柱。 通过将散热器布置在PCB的整个表面上，散热器能够消除更多的热量，并允许电源模块在给定相同的物理尺寸和环境条件下提供更多的输出负载电流。

    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
    8.
    发明授权
    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease 有权
    丝氨酸蛋白酶抑制剂，特别是HCV NS3-NS4A蛋白酶

    公开(公告)号：US07906550B2

    公开(公告)日：2011-03-15

    申请号：US12026705

    申请日：2008-02-06

    Applicant: Kevin M. Cottrell ,  John Maxwell ,  Robert B. Perni ,  Janos Pitlik

    Inventor： Kevin M. Cottrell ,  John Maxwell ,  Robert B. Perni ,  Janos Pitlik

    IPC: A61K31/4025 ,  C07D207/30

    CPC classification number: C07K5/0804 ,  A61K31/40 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.

    Abstract translation: 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐。 因此，它们通过干扰丙型肝炎病毒的生命周期起作用，并且作为抗病毒剂是有用的。 本发明还涉及包含用于离体使用或用于给予HCV感染患者的所述化合物的药学上可接受的组合物以及制备该化合物的方法。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗患者HCV感染的方法。

    Systems and methods for the generation of alternate phrases from packed meaning
    9.
    发明申请
    Systems and methods for the generation of alternate phrases from packed meaning 有权
    从包装意义产生替代短语的系统和方法

    公开(公告)号：US20050137855A1

    公开(公告)日：2005-06-23

    申请号：US10739349

    申请日：2003-12-19

    Applicant: John Maxwell

    Inventor： John Maxwell

    IPC: G06F17/27 ,  G06F17/28

    CPC classification number: G06F17/2881

    Abstract: Techniques are provided to generate alternate phrases from a packed meaning representation. The semantics of input items in a packed meaning representation are matched against a lexicon to determine initial entries in a phrasal information structure. Context, syntax and semantic information describing each phrasal entry are added to the phrasal information structure. Linear or other implications are used to determine a set of unordered rewrite rules. The unordered rewrite rules associate semantic information with pseudofacts such that a complete set of choices from the set of disjunctions in the packed meaning representation is selected. Semantic information associated with the unordered rewrite rules identifies entries in the phrasal information structure to be updated with the pseudofact of the unordered rewrite rule; Entries in the phrasal information structure not associated with false contexts are combined based on ordered rewrite rules. The ordered rewrite rules are based on the language of the packed meaning representation. Source information associated with each new entry in the phrasal information structure reflects the phrasal entry identifiers of the entries used to determine the new entry. For any set of entries in the phrasal information structure produced by an ordered rewrite rule, the context of a missing semantic fact is subtracted from the context of the entry lacking the semantic fact. Entries associated with a false context are discarded and entries sharing the same syntax and semantic information are merged. Any entries in the phrasal information structure associated with the “ALL” pseudofact are then determined. Alternate phrases are generated based on the source information for the entry in the phrasal information structure associated with the “ALL” pseudofact.

    Abstract translation: 提供技术以从打包的意义表示生成替代短语。 打包意义表示中的输入项的语义与词典匹配以确定短语信息结构中的初始条目。 描述每个短语条目的上下文，语法和语义信息被添加到短语信息结构中。 线性或其他含义用于确定一组无序重写规则。 无序重写规则将语义信息与伪文本相关联，使得选择来自包装含义表示中的一组分离的完整的选择集合。 与无序重写规则相关联的语义信息识别要用无序重写规则的伪指令更新的短语信息结构中的条目; 基于有序重写规则组合了与虚假上下文无关的短语信息结构中的条目。 有序重写规则基于打包意义表示的语言。 与短语信息结构中的每个新条目相关联的源信息反映用于确定新条目的条目的短语条目标识符。 对于由有序重写规则产生的短语信息结构中的任何一组条目，从缺少语义事实的条目的上下文中减去缺失语义事实的上下文。 与false上下文关联的条目被丢弃，并且共享相同语法和语义信息的条目被合并。 然后确定与“ALL”pseudofact相关联的短语信息结构中的任何条目。 基于与“ALL”假结构相关联的短语信息结构中的条目的源信息生成替代短语。

    Arrangement for surface mounting of subassemblies on a mother board
    10.
    发明申请
    Arrangement for surface mounting of subassemblies on a mother board 有权
    组件表面安装在母板上的布置

    公开(公告)号：US20050052849A1

    公开(公告)日：2005-03-10

    申请号：US10715907

    申请日：2003-11-18

    Applicant: David Keating ,  Antoin Russell ,  Mysore Divakar ,  Thomas Templeton ,  John Maxwell

    Inventor： David Keating ,  Antoin Russell ,  Mysore Divakar ,  Thomas Templeton ,  John Maxwell

    IPC: H01R20060101 ,  H01R43/02 ,  H05K7/20

    CPC classification number: H01R12/52 ,  H01R12/57 ,  H01R12/7064 ,  H01R43/0263

    Abstract: The invention provides arrangements to facilitate surface mounting of subassembly boards on a motherboard with reliable, high conductivity interconnection. In accordance with the invention, the subassembly interconnection arrangement is composed of separate power and sense connector arms formed on one or more base headers. The arrangement interconnects and supports the subassembly board on the motherboard surface. Each power arm advantageously comprises a plurality of split-based mounting lugs secured to the arm in a coplanar configuration. Each sense connector arm preferably comprises a plurality of connector pins secured to the arm in a coplanar configuration. Embodiments are disclosed for vertical and horizontal surface mounting.

    Abstract translation: 本发明提供了便于在具有可靠的高导电性互连的母板上表面安装子组件板的布置。 根据本发明，子组件互连装置由形成在一个或多个底部集管上的分开的功率和感测连接臂构成。 该布置将主组件板上的子组件板互连并支撑。 每个动力臂有利地包括以共面构造固定到臂的多个基于分组的安装凸耳。 每个感测连接器臂优选地包括以共面构造固定到臂的多个连接器销。 公开了用于垂直和水平表面安装的实施例。

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