公开(公告)号：US08401604B2

公开(公告)日：2013-03-19

申请号：US12101859

申请日：2008-04-11

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: A61B5/1455 ,  A61B6/00

CPC classification number: A61B5/1455 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2560/0252

Abstract: Embodiments of the present system and methods measure a concentration of a substance, such as glucose, in a body. The present embodiments measure a first amount of infrared (IR) radiation absorbed or emitted from the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the body in a second wavelength band. The present embodiments also measure a temperature at a surface of the body and an ambient temperature. A normalized ratio parameter is calculated from the four measurements, and the concentration of the substance in the body is calculated by correlating the normalized ratio parameter with the body surface temperature and the ambient temperature using an empirically derived lookup table. Also disclosed are methods for creating the empirically derived lookup table.

Abstract translation: 本系统和方法的实施例测量身体中诸如葡萄糖的物质的浓度。 本实施例测量在第一波长带中从身体吸收或发射的第一量的红外（IR）辐射和在第二波长带中从身体吸收或发射的第二量的IR辐射。 本实施例还测量身体表面的温度和环境温度。 通过四次测量计算归一化比率参数，并且通过使用经验导出的查找表将归一化比值参数与身体表面温度和环境温度相关联来计算身体中物质的浓度。 还公开了用于创建经验导出的查找表的方法。

公开(公告)号：US08364219B2

公开(公告)日：2013-01-29

申请号：US12629763

申请日：2009-12-02

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye.

Abstract translation: 一种使用具有第一波长的物镜具有非零第一吸收系数的反射测量光和具有第二波长的反射参考光束来测量眼睛中物质浓度的装置和方法 该物质具有基本上等于零的第二吸收系数。 该装置还包括可被定位以接收反射后的测量光束和反射参考光束的检测器。 检测器通过产生测量信号来响应具有第一波长的光，并通过产生参考信号来响应具有第二波长的光。 该装置还包括耦合到检测器的电路。 电路响应测量信号和参考信号来测量眼中物质的浓度。

公开(公告)号：US20090201490A1

公开(公告)日：2009-08-13

申请号：US12029342

申请日：2008-02-11

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: G01N33/48

CPC classification number: A61B5/1455 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/6821 ,  A61B2560/0252

Abstract: A method determines the concentration of a substance in a subject's blood. The method includes noninvasively irradiating an eye with a measurement light beam having a first wavelength and a first power and with a reference light beam having a second wavelength and a second power. The second wavelength is different from the first wavelength. The method further includes measuring at least one of a body temperature of the subject and an ambient temperature of the subject. The method further includes detecting a power of the measurement retro-reflected light beam and detecting a power of the reference retro-reflected light beam. The method further includes calculating a measurement ratio of the detected power of the measurement retro-reflected light beam and the first power and calculating a reference ratio of the detected power of the reference retro-reflected light beam and the second power. The method further includes calculating a parameter dependent on the measurement ratio and the reference ratio and determining a concentration of the substance in the subject's blood in response to the calculated parameter and to the at least one of the body temperature and the ambient temperature.

Abstract translation: 一种方法确定受试者血液中物质的浓度。 该方法包括用具有第一波长和第一功率的测量光束以及具有第二波长和第二功率的参考光束非侵入地照射眼睛。 第二波长与第一波长不同。 该方法还包括测量受试者的体温和受试者的环境温度中的至少一个。 该方法还包括检测测量后反射光束的功率并检测参考反射光束的光焦度。 该方法还包括计算测量反射光束的检测功率和第一功率的测量比，并且计算参考反射光束的检测功率和第二功率的参考比。 该方法还包括根据测量比和参考比计算参数，并响应于所计算的参数和体温和环境温度中的至少一个，确定受试者血液中物质的浓度。

公开(公告)号：US20080111971A1

公开(公告)日：2008-05-15

申请号：US11871044

申请日：2007-10-11

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: A61B3/10

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye.

Abstract translation: 一种使用具有第一波长的物镜具有非零第一吸收系数的反射测量光和具有第二波长的反射参考光束来测量眼睛中物质浓度的装置和方法 该物质具有基本上等于零的第二吸收系数。 该装置还包括可被定位以接收反射后的测量光束和反射参考光束的检测器。 检测器通过产生测量信号来响应具有第一波长的光，并通过产生参考信号来响应具有第二波长的光。 该设备还包括耦合到检测器的电路。 电路响应测量信号和参考信号来测量眼中物质的浓度。

公开(公告)号：US06435711B1

公开(公告)日：2002-08-20

申请号：US09395797

申请日：1999-09-14

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: G01J508

CPC classification number: G01J5/04 ,  G01J5/02 ,  G01J5/0275 ,  G01J5/028 ,  G01J5/049 ,  G01J5/06 ,  G01J5/061 ,  G01J5/16 ,  G01J2005/068

Abstract: An infrared ear thermometer includes a detector head housing, a heat sink, a recess formed in the heat sink, a thermopile sensor mounted within the recess, a thermistor, and temperature determination circuitry. The recess defines an aperture that limits the field of view of the thermopile sensor. The thermal capacities and conductivities of the heat sink and the thermopile sensor are selected so that the output signal of the thermopile sensor stabilizes during a temperature measurement. A method of determining temperature using the ear thermometer takes successive measurements, stores the measurements in a moving time window, averages the measurements in the moving window, determines whether the average has stabilized, and outputs an average temperature. A method of calculating a subject's temperature determines the temperature of a cold junction of the thermopile, looks up a bias and slope of the thermopile based upon the temperature of the cold junction, measures the output of the thermopile, and calculates the subject's temperature based upon a linear relationship between the output and the subject's temperature. The linear relationship is defined by the bias and the slope.

Abstract translation: 红外耳温度计包括检测器头壳体，散热器，形成在散热器中的凹部，安装在凹部内的热电堆传感器，热敏电阻和温度确定电路。 凹槽限定了限制热电堆传感器的视野的孔。 选择散热器和热电堆传感器的热容量和电导率，使得热电堆传感器的输出信号在温度测量期间稳定。 使用耳温度计测定温度的方法是连续的测量，将测量值存储在移动时间窗口中，对移动窗口中的测量进行平均，确定平均值是否稳定，并输出平均温度。 计算受试者温度的方法决定了热电堆的冷连接温度，根据冷连接点的温度查找热电堆的偏压和斜率，测量热电堆的输出，并根据 输出与被摄体温度之间的线性关系。 线性关系由偏差和斜率定义。

公开(公告)号：US4930868A

公开(公告)日：1990-06-05

申请号：US256153

申请日：1988-10-11

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: G02B5/20 ,  G02B5/32 ,  G02B27/10

CPC classification number: G02B27/1013 ,  G02B27/141 ,  G02B5/203 ,  G02B5/32

Abstract: A beam splitter combining the optical apertures of at least three optical (or electro-optical) devices to one optical aperture with respect to a beam of electromagnetic radiation passing therethrough, comprises a dichroic member effective to reflect part of the spectral range of the electromagnetic radiation and to transmit the remainder therethrough; and a grid effective to refract a narrow bandwidth of the electromagnetic radiation and to transmit the remaining electromagnetic radiation therethrough.

Abstract translation: 将至少三个光学（或电光）器件的光学孔径相对于通过其中的电磁辐射束组合到一个光学孔的分束器包括有效地反映电磁辐射的光谱范围的一部分的二向色成分 并通过其余部分传送; 以及有效地折射电磁辐射的窄带宽并透过其余的电磁辐射的电网。

公开(公告)号：US08219169B2

公开(公告)日：2012-07-10

申请号：US12029342

申请日：2008-02-11

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/6821 ,  A61B2560/0252

Abstract: A method determines the concentration of a substance in a subject's blood. The method includes noninvasively irradiating an eye with a measurement light beam having a first wavelength and a first power and with a reference light beam having a second wavelength and a second power. The second wavelength is different from the first wavelength. The method further includes measuring at least one of a body temperature of the subject and an ambient temperature of the subject. The method further includes detecting a power of the measurement retro-reflected light beam and detecting a power of the reference retro-reflected light beam. The method further includes calculating a measurement ratio of the detected power of the measurement retro-reflected light beam and the first power and calculating a reference ratio of the detected power of the reference retro-reflected light beam and the second power. The method further includes calculating a parameter dependent on the measurement ratio and the reference ratio and determining a concentration of the substance in the subject's blood in response to the calculated parameter and to the at least one of the body temperature and the ambient temperature.

Abstract translation: 一种方法确定受试者血液中物质的浓度。 该方法包括用具有第一波长和第一功率的测量光束以及具有第二波长和第二功率的参考光束非侵入地照射眼睛。 第二波长与第一波长不同。 该方法还包括测量受试者的体温和受试者的环境温度中的至少一个。 该方法还包括检测测量后反射光束的功率并检测参考反射光束的光焦度。 该方法还包括计算测量反射光束的检测功率和第一功率的测量比，并且计算参考反射光束的检测功率和第二功率的参考比。 该方法还包括根据测量比和参考比计算参数，并响应于所计算的参数和体温和环境温度中的至少一个，确定受试者血液中物质的浓度。

公开(公告)号：US07643859B2

公开(公告)日：2010-01-05

申请号：US11871044

申请日：2007-10-11

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: A61B5/145

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye.

Abstract translation: 一种使用具有第一波长的物镜具有非零第一吸收系数的反射测量光和具有第二波长的反射参考光束来测量眼睛中物质浓度的装置和方法 该物质具有基本上等于零的第二吸收系数。 该装置还包括可被定位以接收反射后的测量光束和反射参考光束的检测器。 检测器通过产生测量信号来响应具有第一波长的光，并通过产生参考信号来响应具有第二波长的光。 该装置还包括耦合到检测器的电路。 电路响应测量信号和参考信号来测量眼中物质的浓度。

公开(公告)号：US07308293B2

公开(公告)日：2007-12-11

申请号：US10485876

申请日：2002-08-01

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: An apparatus for measuring a concentration of a substance in an eye (13) includes a measurement light source (4) producing a measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient. The apparatus further includes a reference light source (6) producing a reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. At least a portion of the measurement light beam retro-reflects from the retina (17) and at least a portion of the reference light beam retro-reflects from the retina (17). The apparatus further includes a detector (9) responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal.

Abstract translation: 用于测量眼睛中物质浓度的装置（13）包括测量光源（4），其产生具有第一波长的测量光束，物体具有非零第一吸收系数。 该装置还包括产生具有第二波长的参考光束的参考光源（6），在该第二波长处物质具有基本上等于零的第二吸收系数。 测量光束的至少一部分从视网膜（17）反射并且至少一部分参考光束从视网膜（17）反射。 该装置还包括通过产生测量信号并响应于具有第二波长的光而响应于具有第一波长的光的检测器（9），通过产生参考信号。

公开(公告)号：US20100152558A1

公开(公告)日：2010-06-17

申请号：US12629763

申请日：2009-12-02

Applicant: Jonathan Gerlitz

Inventor： Jonathan Gerlitz

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye.

Abstract translation: 一种使用具有第一波长的物镜具有非零第一吸收系数的反射测量光和具有第二波长的反射参考光束来测量眼睛中物质浓度的装置和方法 该物质具有基本上等于零的第二吸收系数。 该装置还包括可被定位以接收反射后的测量光束和反射参考光束的检测器。 检测器通过产生测量信号来响应具有第一波长的光，并通过产生参考信号来响应具有第二波长的光。 该设备还包括耦合到检测器的电路。 电路响应测量信号和参考信号来测量眼中物质的浓度。