公开(公告)号：US11324785B2

公开(公告)日：2022-05-10

申请号：US16324928

申请日：2017-08-11

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do Nam ,  Yun-Tai Kim ,  Hee Soon Shin ,  So-Young Lee ,  Jae-Goo Kim ,  Eun-Yeong Lim ,  Eun-Ji Song

IPC: A61K35/747 ,  A61K35/00 ,  A23L33/135 ,  A61P5/24 ,  C12N1/20 ,  C12R1/225

Abstract: The present invention relates to: a novel Lactobacillus intestinalis YT2 strain (deposition number: KCCM11812P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus intestinalis comprising the novel strain. The present inventors have established an animal model for menopause through ovariectomy, confirmed changes of the distribution of intestinal microorganisms by the model, identified and isolated a novel Lactobacillus intestinalis strain among lactic acid bacteria of which the distribution is significantly reduced in the menopausal model, and confirmed effects, by means of the novel strain and previously reported Lactobacillus intestinalis strains, of alleviating menopausal symptoms, such as the inhibition of an increase in body fat, the inhibition of a decrease in bone mineral density, the inhibition of an increase in the pain sensitivity, and the alleviation of depression. Therefore, it is expected that the composition comprising the Lactobacillus intestinalis according to the present invention can be usable for a use of preventing, alleviating, or treating menopause.

公开(公告)号：US20210393706A1

公开(公告)日：2021-12-23

申请号：US16903955

申请日：2020-06-17

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young Do NAM ,  So Young Lee ,  Hee Soon Shin ,  So Lim Park ,  Won Hyong Chung ,  Eun Sook Lee ,  Eun Ji Song ,  Dong Uk Shin

IPC: A61K35/742 ,  A61P3/04

Abstract: A novel Lactobacillus paracasei AO356 strain according to the present disclosure, which is a strain isolated from the human body, has high stability, exhibits the activity of inhibiting adipogenic differentiation in vitro and inducing the differentiation of M1 and M0 macrophages into M2 macrophages, and has excellent activity of alleviating, preventing, or treating obesity, such as the activity of reducing body weight and a reduction in blood lipid concentration through the browning of white fat in animal experiments. Thus, the novel strain of the present disclosure has a low possibility of causing side effects, and therefore, unlike conventional diet functional foods or drugs, which have side effect problems, a diet effect can be exhibited without controlling the dose thereof. Accordingly, the novel strain can be used as a pharmaceutical composition for treating or preventing obesity or a food composition for alleviating or preventing obesity.

公开(公告)号：US11278579B2

公开(公告)日：2022-03-22

申请号：US16903955

申请日：2020-06-17

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young Do Nam ,  So Young Lee ,  Hee Soon Shin ,  So Lim Park ,  Won Hyong Chung ,  Eun Sook Lee ,  Eun Ji Song ,  Dong Uk Shin

IPC: A61K35/747 ,  A61K39/09 ,  A61K35/00 ,  A61K35/742 ,  C12R1/225

Abstract: A novel Lactobacillus paracasei AO356 strain according to the present disclosure, which is a strain isolated from the human body, has high stability, exhibits the activity of inhibiting adipogenic differentiation in vitro and inducing the differentiation of M1 and M0 macrophages into M2 macrophages, and has excellent activity of alleviating, preventing, or treating obesity, such as the activity of reducing body weight and a reduction in blood lipid concentration through the browning of white fat in animal experiments. Thus, the novel strain of the present disclosure has a low possibility of causing side effects, and therefore, unlike conventional diet functional foods or drugs, which have side effect problems, a diet effect can be exhibited without controlling the dose thereof. Accordingly, the novel strain can be used as a pharmaceutical composition for treating or preventing obesity or a food composition for alleviating or preventing obesity.

公开(公告)号：US12016890B2

公开(公告)日：2024-06-25

申请号：US17714361

申请日：2022-04-06

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do Nam ,  Yun-Tai Kim ,  Hee Soon Shin ,  So-Young Lee ,  Jae-Goo Kim ,  Eun-Yeong Lim ,  Eun-Ji Song

IPC: A61K35/747 ,  A23L33/135 ,  A61K35/00 ,  C12R1/225

CPC classification number: A61K35/747 ,  A23L33/135 ,  A61K2035/115 ,  C12R2001/225

Abstract: The present invention relates to: a novel Lactobacillus intestinalis YT2 strain (deposition number: KCCM11812P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus intestinalis comprising the novel strain. The present inventors have established an animal model for menopause through ovariectomy, confirmed changes of the distribution of intestinal microorganisms by the model, identified and isolated a novel Lactobacillus intestinalis strain among lactic acid bacteria of which the distribution is significantly reduced in the menopausal model, and confirmed effects, by means of the novel strain and previously reported Lactobacillus intestinalis strains, of alleviating menopausal symptoms, such as the inhibition of an increase in body fat, the inhibition of a decrease in bone mineral density, the inhibition of an increase in the pain sensitivity, and the alleviation of depression. Therefore, it is expected that the composition comprising the Lactobacillus intestinalis according to the present invention can be usable for a use of preventing, alleviating, or treating menopause.

公开(公告)号：US11260087B2

公开(公告)日：2022-03-01

申请号：US16325018

申请日：2017-08-11

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do Nam ,  Yun-Tai Kim ,  Hee Soon Shin ,  So-Young Lee ,  Jae-Goo Kim ,  Eun-Yeong Lim ,  Eun-Ji Song

IPC: A61K35/747 ,  C12N1/20 ,  A23L33/135 ,  A61Q19/08 ,  A61P15/00 ,  A61K8/99 ,  A61Q19/00 ,  C12R1/23

Abstract: Provided is a novel Lactobacillus acidophilus YTI strain (deposition number: KCCM 11808P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus acidophilus comprising the novel strain.