公开(公告)号：US11261271B2

公开(公告)日：2022-03-01

申请号：US16536907

申请日：2019-08-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Chang Song ,  Bo Bae Seo

IPC: C08F30/02 ,  A61L27/16 ,  A61L27/36 ,  A61L27/52

Abstract: Provided is a thermosensitive phosphazene-based polymer including an amino acid ester moiety, a polyethyleneglycol moiety, and a moiety including a sulfate group linked directly or by a linker in a predetermined ratio, a method of preparing the same, and a hydrogel-formable composition including the same. For example, a hydrogel formed from the composition may be used for tissue regeneration or drug delivery or used as a storage, a body tissue regeneration inducer, or a filler in a body.

公开(公告)号：US10799529B2

公开(公告)日：2020-10-13

申请号：US16567027

申请日：2019-09-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Chang Song ,  Young-min Kim

IPC: A61K31/80 ,  A61P25/00

Abstract: The present disclosure relates to a pharmaceutical composition for preventing or treating spinal cord injury comprising an imidazole-poly(organophosphazene) hydrogel or a pharmaceutically acceptable salt thereof, a method for preventing or treating spinal cord injury, and a food composition for preventing or ameliorating spinal cord injury.The imidazole-poly(organophosphazene) hydrogel of the present disclosure has the effect of regenerating the extracellular matrix (ECM) by filling cystic cavities and can thus be effectively used for the prevention and treatment of spinal cord injury by a simple injection method.

公开(公告)号：US10603404B2

公开(公告)日：2020-03-31

申请号：US15809022

申请日：2017-11-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Chang Song ,  Young-Min Kim ,  ChangHo Kim

IPC: A61L26/00 ,  A61L24/04 ,  C08G79/025

Abstract: The present invention relates to a phosphazene-based polymer comprising an amino acid ester, polyethylene glycol, a group comprising a functional group, and a catechol group linked directly or by a linker to a part of or an entire functional group, in a predetermined ratio. In addition, the present invention relates to a preparation method thereof, and a tissue-adhesive composition comprising the same as an active ingredient.

公开(公告)号：US20200048377A1

公开(公告)日：2020-02-13

申请号：US16536907

申请日：2019-08-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Chang Song ,  Bo Bae Seo

IPC: C08F30/02 ,  A61L27/52 ,  A61L27/36 ,  A61L27/16

Abstract: Provided is a thermosensitive phosphazene-based polymer including an amino acid ester moiety, a polyethyleneglycol moiety, and a moiety including a sulfate group linked directly or by a linker in a predetermined ratio, a method of preparing the same, and a hydrogel-formable composition including the same. For example, a hydrogel formed from the composition may be used for tissue regeneration or drug delivery or used as a storage, a body tissue regeneration inducer, or a filler in a body.