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    Reducing optical interference in a fluidic device
    5.
    发明授权
    Reducing optical interference in a fluidic device 有权

    公开(公告)号：US11215610B2

    公开(公告)日：2022-01-04

    申请号：US15951720

    申请日：2018-04-12

    Applicant: Labrador Diagnostics LLC

    Inventor： Ian Gibbons ,  Michael O'Connell

    IPC: B01L3/00 ,  G01N33/53 ,  G01N33/536

    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces interference with an optical signal which is indicative of the presence of an analyte in a bodily sample.

    Integrated health data capture and analysis system
    6.
    发明授权
    Integrated health data capture and analysis system 有权

    公开(公告)号：US11195624B2

    公开(公告)日：2021-12-07

    申请号：US15952983

    申请日：2018-04-13

    Applicant: Labrador Diagnostics LLC

    Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Daniel Young ,  Seth G. Michelson

    IPC: G16H50/50 ,  G16H50/70 ,  G16H50/20 ,  G16H50/80 ,  G16Z99/00

    Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.

    Rapid, low-sample-volume cholesterol and triglyceride assays
    8.
    发明授权
    Rapid, low-sample-volume cholesterol and triglyceride assays 有权

    公开(公告)号：US11268130B2

    公开(公告)日：2022-03-08

    申请号：US16530322

    申请日：2019-08-02

    Applicant: Labrador Diagnostics LLC

    Inventor： Douglas Matje ,  Ian Gibbons ,  Paul Patel ,  Elizabeth A. Holmes

    IPC: C12Q1/60 ,  C12Q1/61 ,  G01N33/92 ,  C12Q1/26 ,  C12Q1/44

    Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed. Assays may be performed in a single reaction mixture, allowing more accurate and precise cholesterol determinations, including ratios of cholesterol sub-fractions to total cholesterol, at less expense, than would be expected by performing several different assays in different reaction mixtures.

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