公开(公告)号：US11320355B2

公开(公告)日：2022-05-03

申请号：US16259511

申请日：2019-01-28

Applicant: Labrador Diagnostics LLC

Inventor： Mark Dayel ,  Samartha Anekal ,  Elizabeth A. Holmes

IPC: G01N15/04 ,  G01N15/05 ,  G01N33/49 ,  G01N15/00

Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.

公开(公告)号：US11008628B1

公开(公告)日：2021-05-18

申请号：US14490653

申请日：2014-09-18

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Timothy Smith ,  Samartha Anekal ,  James R. Wasson ,  Daniel L. Young ,  Chinmay Pangarkar

IPC: C12Q1/70 ,  G01N33/569 ,  B01L7/00 ,  B01L3/00

Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.

公开(公告)号：US10989724B1

公开(公告)日：2021-04-27

申请号：US15664108

申请日：2017-07-31

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Samartha Anekal ,  Timothy Smith ,  James R. Wasson ,  Chinmay Pangarkar

IPC: G01N15/00 ,  G01N21/00 ,  G01N35/04 ,  G01J3/28 ,  G01N15/14

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US12209290B2

公开(公告)日：2025-01-28

申请号：US17319906

申请日：2021-05-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Timothy Smith ,  Samartha Anekal ,  James R. Wasson ,  Daniel L. Young ,  Chinmay Pangarkar

IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/70 ,  G01N33/569

Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.

公开(公告)号：US11524299B2

公开(公告)日：2022-12-13

申请号：US16712664

申请日：2019-12-12

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Joy Roy ,  John Kent Frankovich ,  Daniel L. Young ,  Timothy Smith ,  Chinmay Pangarkar ,  Samartha Anekal

IPC: G01N35/00 ,  B01L3/00 ,  G01N35/10 ,  B01L3/02 ,  B01L7/00 ,  B01L9/06

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20210318348A1

公开(公告)日：2021-10-14

申请号：US17236835

申请日：2021-04-21

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Samartha Anekal ,  Timothy Smith ,  James R. Wasson ,  Chinmay Pangarkar

IPC: G01N35/04 ,  G01J3/28 ,  G01N15/14

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20220072554A1

公开(公告)日：2022-03-10

申请号：US17402816

申请日：2021-08-16

Applicant: Labrador Diagnostics LLC

Inventor： Gary Frenzel ,  Samartha Anekal ,  Daniel Young

IPC: B01L3/00

Abstract: In one embodiment described herein, a cartridge is provided comprising a cartridge frame; a plurality of diluents each in an expandable container; a plurality of reagents each in an expandable container; and a plurality of mixing vessels comprising empty expandable containers.

公开(公告)号：US20210031148A1

公开(公告)日：2021-02-04

申请号：US16931127

申请日：2020-07-16

Applicant: Labrador Diagnostics LLC

Inventor： Samartha Anekal ,  Deborah Sloan

IPC: B01D69/12 ,  A61M1/34 ,  B01D69/06 ,  B01D71/68 ,  B01D65/02 ,  B01D67/00

Abstract: In one embodiment described herein, a bodily fluid separation material is provided comprising a formed component capture region and a bodily fluid pass-through region. The pass-through region has structures with a reduced liquid leaching quality relative to than the capture region, wherein during separation material use, bodily fluid enters the capture region prior to entering the pass-through region. Optionally, a bodily fluid pass-through region has a reduced amount of liquid leaching material relative to than the capture region.

公开(公告)号：US20220170951A1

公开(公告)日：2022-06-02

申请号：US17466314

申请日：2021-09-03

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Samartha Anekal ,  Chinmay Pangarkar

IPC: G01N35/00 ,  G01N15/14 ,  G01N21/01 ,  B01L3/00

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20220137075A1

公开(公告)日：2022-05-05

申请号：US17470596

申请日：2021-09-09

Applicant: Labrador Diagnostics LLC

Inventor： Mark Dayel ,  Samartha Anekal ,  Paul Patel ,  Ian Gibbons ,  Elizabeth A. Holmes

IPC: G01N33/86 ,  C12Q1/56 ,  G01N21/84 ,  G01N33/49 ,  G01N33/58

Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 μL) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.