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公开(公告)号：US10548663B2
公开(公告)日：2020-02-04
申请号：US14891652
申请日：2014-05-16
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Leonel Mendoza , Martha A. Barajas-Torres
Abstract: Neuromodulation catheters with shafts for enhanced flexibility and control and methods of making and using the catheters. A neuromodulation catheter can include an elongated shaft having a distal end portion and a mandrel extending at least along the distal end portion. The mandrel can have an at least substantially solid core. The neuromodulation catheter can further include a transition member and a neuromodulation assembly coupled to the transition member. The transition member can have a proximal portion, a distal portion, and a guide wire lumen extending through the proximal and distal portions. The neuromodulation assembly can extend distally from the distal portion of the transition member, and the mandrel can extend proximally from the proximal portion of the transition member.
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公开(公告)号：US09492635B2
公开(公告)日：2016-11-15
申请号：US14716631
申请日：2015-05-19
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Justin Goshgarian , Vincent Ku
IPC: A61M25/00 , A61B18/14 , A61N1/05 , A61N1/06 , A61B17/32 , A61B18/02 , A61B18/06 , A61F7/00 , A61F7/12 , A61N7/00 , A61B18/00
CPC classification number: A61M25/0053 , A61B17/320068 , A61B18/02 , A61B18/06 , A61B18/1492 , A61B2018/00386 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61F7/007 , A61F7/0085 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/0051 , A61M25/0054 , A61N1/0551 , A61N1/056 , A61N1/06 , A61N7/00 , A61N2007/0021
Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
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3.发明申请CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS 审中-公开具有增强灵活性和相关设备，系统和方法的导管公开(公告)号：US20150250981A1
公开(公告)日：2015-09-10
申请号：US14716631
申请日：2015-05-19
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Justin Goshgarian , Vincent Ku
CPC classification number: A61M25/0053 , A61B17/320068 , A61B18/02 , A61B18/06 , A61B18/1492 , A61B2018/00386 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61F7/007 , A61F7/0085 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/0051 , A61M25/0054 , A61N1/0551 , A61N1/056 , A61N1/06 , A61N7/00 , A61N2007/0021
Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
Abstract translation: 神经调节导管包括细长轴和神经调节元件。 轴包括沿着轴的纵向轴线延伸的沿着螺旋路径的两个或更多个第一切割形状和两个或更多个第二切割形状。 第一切割形状被配置为至少部分地抵抗在轴上的纵向压缩和张力以及在第一圆周方向上的扭转的变形。 第二切割形状被构造成至少部分地抵抗在轴上的纵向压缩和在第一和第二相对圆周方向上的轴上的扭转的变形。
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4.发明授权Catheters with enhanced flexibility and associated devices, systems, and methods 有权导管具有增强的灵活性和相关的设备，系统和方法公开(公告)号：US09044575B2
公开(公告)日：2015-06-02
申请号：US14060564
申请日：2013-10-22
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Justin Goshgarian , Vincent Ku
CPC classification number: A61M25/0053 , A61B17/320068 , A61B18/02 , A61B18/06 , A61B18/1492 , A61B2018/00386 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61F7/007 , A61F7/0085 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/0051 , A61M25/0054 , A61N1/0551 , A61N1/056 , A61N1/06 , A61N7/00 , A61N2007/0021
Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
Abstract translation: 神经调节导管包括细长轴和神经调节元件。 轴包括沿着轴的纵向轴线延伸的沿着螺旋路径的两个或更多个第一切割形状和两个或更多个第二切割形状。 第一切割形状被配置为至少部分地抵抗在轴上的纵向压缩和张力以及在第一圆周方向上的扭转的变形。 第二切割形状被构造成至少部分地抵抗在轴上的纵向压缩和在第一和第二相对圆周方向上的轴上的扭转的变形。
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公开(公告)号：US11376398B2
公开(公告)日：2022-07-05
申请号：US17503866
申请日：2021-10-18
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Justin Goshgarian , Vincent Ku
IPC: A61M25/00 , A61B18/14 , A61B17/32 , A61N1/05 , A61N1/06 , A61B18/00 , A61B18/02 , A61B18/06 , A61F7/00 , A61F7/12 , A61N7/00
Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
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Patent Agency Ranking
公开(公告)号：US11147948B2
公开(公告)日：2021-10-19
申请号：US16221220
申请日：2018-12-14
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Justin Goshgarian , Vincent Ku
IPC: A61M25/00 , A61B18/14 , A61N1/05 , A61N1/06 , A61B18/02 , A61B18/06 , A61F7/00 , A61F7/12 , A61N7/00 , A61B17/32 , A61B18/00
Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
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公开(公告)号：US09597018B2
公开(公告)日：2017-03-21
申请号：US13791751
申请日：2013-03-08
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Ayala Hezi-Yamit , Michele Lee Silver , Christopher W. Storment
IPC: A61B5/157 , A61N1/05 , A61B5/00 , A61N1/36 , A61B5/145 , A61B5/15 , A61B10/00 , A61B5/20 , A61B18/14 , A61B18/18 , A61N1/32 , G01N33/68 , A61B18/00
CPC classification number: A61B5/157 , A61B5/1405 , A61B5/14503 , A61B5/14546 , A61B5/15003 , A61B5/150229 , A61B5/150992 , A61B5/20 , A61B5/201 , A61B5/4035 , A61B5/4836 , A61B5/4848 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B5/6858 , A61B10/0045 , A61B10/007 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B2018/00166 , A61B2018/00214 , A61B2018/0022 , A61B2018/00279 , A61B2018/00345 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00875 , A61B2018/0212 , A61N1/05 , A61N1/32 , A61N1/36007 , A61N1/3605 , A61N1/40 , A61N7/02 , G01N33/68 , G01N2800/347
Abstract: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to biomarker sampling in the context of neuromodulation devices, systems, and methods. Some embodiments, for example, are directed to catheters, catheter systems, and methods for sampling biomarkers that change in response to neuromodulation. A system can include, for example, an elongated shaft and a neuromodulation and sampling assembly having a neuromodulation and a sampling element.
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8.发明申请CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS 有权具有增强灵活性和相关设备，系统和方法的导管公开(公告)号：US20170056619A1
公开(公告)日：2017-03-02
申请号：US15227691
申请日：2016-08-03
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Justin Goshgarian , Vincent Ku
CPC classification number: A61M25/0053 , A61B17/320068 , A61B18/02 , A61B18/06 , A61B18/1492 , A61B2018/00386 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61F7/007 , A61F7/0085 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/0051 , A61M25/0054 , A61N1/0551 , A61N1/056 , A61N1/06 , A61N7/00 , A61N2007/0021
Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
Abstract translation: 神经调节导管包括细长轴和神经调节元件。 轴包括沿着轴的纵向轴线延伸的沿着螺旋路径的两个或更多个第一切割形状和两个或更多个第二切割形状。 第一切割形状被配置为至少部分地抵抗在轴上的纵向压缩和张力以及在第一圆周方向上的扭转的变形。 第二切割形状被构造成至少部分地抵抗在轴上的纵向压缩和在第一和第二相对圆周方向上的轴上的扭转的变形。
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公开(公告)号：US11338140B2
公开(公告)日：2022-05-24
申请号：US15667901
申请日：2017-08-03
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Ayala Hezi-Yamit , Rudy Beasley , Susan Edwards , Lori Garcia , Michele Lee Silver , Christopher W. Storment , Carol M. Sullivan , Joseph A. Traina , Stefan Stoyanov Tunev
IPC: A61B5/145 , A61B18/14 , A61B5/00 , A61B18/02 , A61N1/36 , A61B18/00 , A61N1/05 , A61B5/20 , A61B5/15 , A61B5/157 , A61B10/00 , A61B18/18 , A61N1/32 , G01N33/68 , A61N1/40 , A61N7/02
Abstract: Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers. One aspect includes a comparison of baseline and post-modulation levels of one or more biomarkers in bodily fluid that have each been collected from a human subject at a relevant time, and that may be used to assess the neuromodulation efficacy. The post-neuromodulation levels for the one or more biomarkers may be collected from the human subject within about 5 minutes to about 14 days post-neuromodulation.
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公开(公告)号：US20220032004A1
公开(公告)日：2022-02-03
申请号：US17503866
申请日：2021-10-18
Applicant: Medtronic Ardian Luxembourg S.a.r.l.
Inventor： Rudy Beasley , Justin Goshgarian , Vincent Ku
IPC: A61M25/00 , A61B18/14 , A61N1/05 , A61N1/06 , A61B18/02 , A61B18/06 , A61F7/00 , A61F7/12 , A61N7/00 , A61B17/32
Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
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