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公开(公告)号：US10256262B2
公开(公告)日：2019-04-09
申请号：US14301187
申请日：2014-06-10
Inventor： Gabriel Popescu , Ramachandra Dasari , Michael Feld , Takahiro Ikeda
Abstract: Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.
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Patent Agency Ranking
2.发明授权公开(公告)号：US09546952B2
公开(公告)日：2017-01-17
申请号：US14490242
申请日：2014-09-18
Applicant: Massachusetts Institute of Technology
Inventor： Wonshik Choi , Ramachandra Dasari , Christopher Fang-Yen , Michael Feld
CPC classification number: G01N21/45 , G01N21/51 , G01N21/6458 , G01N21/6486 , G01N2021/458 , G01N2201/061 , G01N2201/105 , G01N2201/12
Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.
Abstract translation: 本发明涉及使用具有可变照明角度的移相激光干涉显微镜对活体或非活细胞，组织或微生物中的折射率进行定量三维映射的系统和方法。 优选的实施方案提供细胞和多细胞生物的层析成像，以及在组织光散射中具有多种应用的高分辨率显微镜中细胞结构的时间依赖性变化和样品诱导的像差的定量表征。
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公开(公告)号：US09528817B2
公开(公告)日：2016-12-27
申请号：US13715475
申请日：2012-12-14
Applicant: Massachusetts Institute of Technology
Inventor： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
CPC classification number: G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement of biological materials which can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering.
Abstract translation: 本发明的优选实施方案涉及可应用于例如细胞生理学和神经科学领域的生物材料的相位测量系统。 这些优选实施例基于相位测量和成像技术的原理。 使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。 亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。
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公开(公告)号：US20160100777A1
公开(公告)日：2016-04-14
申请号：US14800142
申请日：2015-07-15
Applicant: Massachusetts Institute of Technology
Inventor： Kate Bechtel , Wei-Chuan Shih , Michael Feld
IPC: A61B5/1455 , A61B5/1495 , A61B5/145
CPC classification number: A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1495 , A61B2560/0223 , G01N21/65
Abstract: The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.
Abstract translation: 本发明涉及用于测量诸如葡萄糖的分析物的系统和方法。 使用拉曼和反射光谱来测量受试者内的材料，例如血液样本或组织的体积，并根据其测定血液分析物的浓度。 本发明还涉及校准方法，约束正则化（CR），并证明其用于分析光谱的用途，包括例如使用经皮拉曼光谱测量葡萄糖浓度。
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公开(公告)号：US20170281059A9
公开(公告)日：2017-10-05
申请号：US14800142
申请日：2015-07-15
Applicant: Massachusetts Institute of Technology
Inventor： Kate Bechtel , Wei-Chuan Shih , Michael Feld
IPC: A61B5/1455 , A61B5/1495 , A61B5/145
CPC classification number: A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1495 , A61B2560/0223 , G01N21/65
Abstract: The present invention relates to systems and methods for the measurement of analytes such as glucose. Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR), and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.
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公开(公告)号：US20170202462A1
公开(公告)日：2017-07-20
申请号：US15388640
申请日：2016-12-22
Applicant: Massachusetts Institute of Technology
Inventor： Jason Motz , Luis H. Galindo , Martin Hunter , Abigail S. Haka , Saumil Gandhi , Ramachandra Dasari , Michael Feld
CPC classification number: A61B5/0086 , A61B1/07 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/415 , A61B5/441 , A61B5/4519 , A61B5/4872 , A61B5/6848 , A61B10/0233 , A61B2010/045 , G01N21/65 , G01N2021/656
Abstract: The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.
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