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    Reagents for enhanced detection of low volatility analytes
    4.
    发明授权
    Reagents for enhanced detection of low volatility analytes 有权

    公开(公告)号：US11543399B2

    公开(公告)日：2023-01-03

    申请号：US16506780

    申请日：2019-07-09

    Applicant: Massachusetts Institute of Technology

    Inventor： Jude A. Kelley ,  Roderick Russell Kunz ,  Alla Ostrinskaya ,  Richard Paul Kingsborough

    IPC: G01N33/22 ,  G01N27/623

    Abstract: The use of volatilization reagents is disclosed for improved detection of inorganic oxidizers such as, but not limited to, chlorates and perchlorates. Detection methods are disclosed whereby a reagent can transfer a proton to the anion (i.e., chlorate, perchlorate, etc.) of an inorganic salt analyte, forming an acid (i.e., chloric acid, perchloric acid) that is easier to detect by a mechanism whereby the acidified reagent is more easily vaporized, and hence, more easily detected. Concurrently, the anion of the acid forms a new salt with the cation released from the salt that was acidified. The reagents can also include acidic salts or cation-donators, more generally. In some embodiments, hydrated reagents or co-reagents that can release water can be employed.

    Substrate containing latent vaporization reagents
    5.
    发明授权
    Substrate containing latent vaporization reagents 有权

    公开(公告)号：US10816530B2

    公开(公告)日：2020-10-27

    申请号：US15687010

    申请日：2017-08-25

    Applicant: Massachusetts Institute of Technology

    Inventor： Jude Aaron Kelley ,  Richard Paul Kingsborough ,  Roderick Russell Kunz

    IPC: G01N33/22 ,  G01N27/62 ,  G01N1/44 ,  H01J49/00

    Abstract: Methods and reagents are disclosed for improved detection of inorganic oxidizers, such as but not limited to chlorates, perchlorates, permanganates, dichromates, and osmium tetraoxides. In one aspect of the invention, latent acid-generating reagents are employed that are chemically stable at room temperature but undergo an acidic transformation when exposed to an elevated temperature or radiation. The latent reagent can be activated by heat or radiation (e.g., UV radiation). The resulting acidic reagent can then transfer a proton to the anion (i.e., chlorate, perchlorate, etc.) of the target analyte, forming an acid (i.e., chloric acid, perchloric acid) that is more easily vaporized and, hence, more easily detected. In another aspect of the invention, heat-sensitive inorganic salts and/or photosensitive onium salts are disclosed as reagents to carry out this method. In various embodiments, these reagents can be embedded in a swipe or other substrate, infused onto the swipe or sample via nebulizer, or otherwise deployed in a desorption chamber of an ion mobility spectrometer or similar detector.

    Reagents for enhanced detection of low volatility analytes
    6.
    发明授权
    Reagents for enhanced detection of low volatility analytes 有权

    公开(公告)号：US10345281B2

    公开(公告)日：2019-07-09

    申请号：US14679891

    申请日：2015-04-06

    Applicant: Massachusetts Institute of Technology

    Inventor： Jude A. Kelley ,  Roderick Russell Kunz ,  Alla Ostrinskaya ,  Richard Paul Kingsborough

    IPC: G01N33/22 ,  G01N27/62

    Abstract: Volatilization reagents are disclosed for improved detection of inorganic oxidizers such as chlorates and perchlorates by mass spectrometry. Thermal desorption methods are also disclosed in which the reagent transfers a proton to the anion (i.e., chlorate, perchlorate, etc.) of an inorganic salt analyte, forming an acid (i.e., chloric acid, perchloric acid) that is more easily vaporized and, hence, more easily detected. The reagents can include acidic salts or cation-donators, more generally. The class of reagents including polymeric acids, polymeric organic acids and polymeric sulfonic acids. Hydrated reagents or other reagents that can release water can also be employed as co-reagents. Further, these reagents can be embedded in a swipe or other substrate, delivered as a liquid infused via nebulizer, or otherwise introduced to a sample to be tested.

    Substrate Containing Latent Vaporization Reagents
    7.
    发明申请
    Substrate Containing Latent Vaporization Reagents 审中-公开

    公开(公告)号：US20180059086A1

    公开(公告)日：2018-03-01

    申请号：US15687010

    申请日：2017-08-25

    Applicant: Massachusetts Institute of Technology

    Inventor： Jude Aaron Kelley ,  Richard Paul Kingsborough ,  Roderick Russell Kunz

    IPC: G01N33/22 ,  G01N27/62 ,  G01N1/44 ,  H01J49/00

    CPC classification number: G01N33/227 ,  G01N1/44 ,  G01N27/622 ,  H01J49/0031 ,  Y10T436/19 ,  Y10T436/24

    Abstract: Methods and reagents are disclosed for improved detection of inorganic oxidizers, such as but not limited to chlorates, perchlorates, permanganates, dichromates, and osmium tetraoxides. In one aspect of the invention, latent acid-generating reagents are employed that are chemically stable at room temperature but undergo an acidic transformation when exposed to an elevated temperature or radiation. The latent reagent can be activated by heat or radiation (e.g., UV radiation). The resulting acidic reagent can then transfer a proton to the anion (i.e., chlorate, perchlorate, etc.) of the target analyte, forming an acid (i.e., chloric acid, perchloric acid) that is more easily vaporized and, hence, more easily detected. In another aspect of the invention, heat-sensitive inorganic salts and/or photosensitive onium salts are disclosed as reagents to carry out this method. In various embodiments, these reagents can be embedded in a swipe or other substrate, infused onto the swipe or sample via nebulizer, or otherwise deployed in a desorption chamber of an ion mobility spectrometer or similar detector.

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