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1.发明申请公开(公告)号：US20130083326A1
公开(公告)日：2013-04-04
申请号：US13250478
申请日：2011-09-30
Applicant: Matthew Clark , Terry Dean Stark , George Goblish , Myles Koshiol
Inventor： Matthew Clark , Terry Dean Stark , George Goblish , Myles Koshiol
CPC classification number: G01K1/16
Abstract: A temperature sensor package includes a temperature sensor having a first side and a second side, wherein the first side of the temperature sensor includes an active region configured for coupling with a target area for temperature measurement of an object. The temperature sensor package further includes a circuit board having a first side and a second side, the first side of the circuit board coupled to the second side of the temperature sensor, wherein the circuit board provides thermal insulation between the active region of the temperature sensor and an environment on the second side of the circuit board.
Abstract translation: 温度传感器封装包括具有第一侧和第二侧的温度传感器，其中温度传感器的第一侧包括被配置为与目标区域耦合以用于物体的温度测量的有源区域。 温度传感器封装还包括具有第一侧和第二侧的电路板，电路板的第一侧耦合到温度传感器的第二侧，其中电路板在温度传感器的有源区域之间提供热绝缘 以及电路板第二面上的环境。
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公开(公告)号：US20110130968A1
公开(公告)日：2011-06-02
申请号：US12626911
申请日：2009-11-29
Applicant: Matthew Clark
Inventor： Matthew Clark
CPC classification number: G16B15/00
Abstract: Methods and systems for computing the binding free energy of a ligand to a host are disclosed. The method entails selecting random poses of a ligand, including translation, rotation, and conformation, and computing the ligand-host interaction energy. The poses are accepted or rejected based on the Metropolis criteria. The entropies of interaction are estimated from the log of the ratio of accepted poses to attempted poses. The free energy of the entire sampling region, and of sub-regions of the binding region, can be accumulated by storing the energies and acceptance ratios for both the entire region and the sub regions. In order to better shape the protein to the ligand, energy minimization of the host atoms in the region of the ligand is carried out in the presence of the lowest free-energy pose of the ligand, optionally preceded by random perturbation of the Cartesian coordinates of the host atoms in the vicinity of the ligand.
Abstract translation: 公开了用于计算配体与宿主的结合自由能的方法和系统。 该方法需要选择配体的随机姿态，包括平移，旋转和构象，以及计算配体 - 宿主相互作用能。 根据Metropolis标准接受或拒绝姿势。 相互作用的熵是从接受的姿势与尝试姿势的比率的对数估计的。 可以通过存储整个区域和子区域的能量和接受比率来累积整个采样区域和结合区域的子区域的自由能。 为了更好地将蛋白质形成配体，配体区域中的宿主原子的能量最小化在配体的最低自由能姿势存在的情况下进行，任选地在随机扰动笛卡尔坐标 主体原子在配体附近。
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公开(公告)号：US20100120772A1
公开(公告)日：2010-05-13
申请号：US12375184
申请日：2007-08-01
Applicant: Matthew Clark
Inventor： Matthew Clark
IPC: A61K31/53 , C07D251/54 , A61P19/02
CPC classification number: C07D251/70 , C40B40/00
Abstract: Compounds of formula (I) and (II) are disclosed, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use in treating disease. The compounds inhibit the production of TNF-alpha and interleukins (IL) by the inhibition of p38 kinase. They are useful in the treatment of inflammation and arthritis.
Abstract translation: 公开了式（I）和（II）的化合物，以及其鉴定方法，制备方法，含有它们的药物组合物及其在治疗疾病中的用途。 该化合物通过抑制p38激酶抑制TNF-α和白介素（IL）的产生。 它们可用于治疗炎症和关节炎。
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公开(公告)号：US20070224607A1
公开(公告)日：2007-09-27
申请号：US11584880
申请日：2006-10-23
Applicant: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
Inventor： Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
CPC classification number: C12N15/1068 , C07H21/00
Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
Abstract translation: 本发明提供了通过筛选包括编码寡核苷酸标签的分子文库来鉴定感兴趣的化合物的方法。
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5.发明授权公开(公告)号：US08905635B2
公开(公告)日：2014-12-09
申请号：US13250478
申请日：2011-09-30
Applicant: Matthew Clark , Terry Dean Stark , George Goblish , Myles Koshiol
Inventor： Matthew Clark , Terry Dean Stark , George Goblish , Myles Koshiol
CPC classification number: G01K1/16
Abstract: A temperature sensor package includes a temperature sensor having a first side and a second side, wherein the first side of the temperature sensor includes an active region configured for coupling with a target area for temperature measurement of an object. The temperature sensor package further includes a circuit board having a first side and a second side, the first side of the circuit board coupled to the second side of the temperature sensor, wherein the circuit board provides thermal insulation between the active region of the temperature sensor and an environment on the second side of the circuit board.
Abstract translation: 温度传感器封装包括具有第一侧和第二侧的温度传感器，其中温度传感器的第一侧包括被配置为与目标区域耦合以用于物体的温度测量的有源区域。 温度传感器封装还包括具有第一侧和第二侧的电路板，电路板的第一侧耦合到温度传感器的第二侧，其中电路板在温度传感器的有源区域之间提供热绝缘 以及电路板第二面上的环境。
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Patent Agency Ranking
公开(公告)号：US20120048020A1
公开(公告)日：2012-03-01
申请号：US12301915
申请日：2007-05-24
Applicant: Matthew Clark
Inventor： Matthew Clark
IPC: G01N29/24
CPC classification number: G01N29/2418 , G10K15/046
Abstract: A generator structure has alternating linear regions which are respectively relatively absorbing and relatively non-absorbing. When the structure is illuminated, the spatial contrast in the absorption created by the characteristics of the regions gives rise to mechanical effects within the workpiece, such as localized heating. This results in ultrasound being created to propagate through the workpiece.
Abstract translation: 发电机结构具有相互吸收且相对不吸收的交替线性区域。 当结构被照亮时，由区域的特征产生的吸收的空间对比度在工件内产生机械效应，例如局部加热。 这导致产生超声以传播通过工件。
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公开(公告)号：US08119798B2
公开(公告)日：2012-02-21
申请号：US12375184
申请日：2007-08-01
Applicant: Matthew Clark
Inventor： Matthew Clark
IPC: C07D251/70 , C07D251/54 , A61K31/53 , A61P19/02
CPC classification number: C07D251/70 , C40B40/00
Abstract: Compounds of formula (I) and (II) are disclosed, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use in treating disease. The compounds inhibit the production of TNF-alpha and interleukins (IL) by the inhibition of p38 kinase. They are useful in the treatment of inflammation and arthritis.
Abstract translation: 公开了式（I）和（II）的化合物，以及其鉴定方法，制备方法，含有它们的药物组合物及其在治疗疾病中的用途。 该化合物通过抑制p38激酶抑制TNF-α和白介素（IL）的产生。 它们可用于治疗炎症和关节炎。
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8.发明申请公开(公告)号：US20120040118A1
公开(公告)日：2012-02-16
申请号：US13284284
申请日：2011-10-28
Applicant: William Doyle , Matthew Clark , Travis Honeycutt
Inventor： William Doyle , Matthew Clark , Travis Honeycutt
IPC: B32B1/08 , C09J107/02 , C08L7/02
CPC classification number: C08C1/04 , C08K3/22 , Y10S524/925 , Y10T428/1334 , Y10T428/1352 , C08L7/02
Abstract: A rubber latex composition is disclosed having reduced allergenicity. Methods for producing a rubber latex composition having reduced allergenicity are also disclosed.
Abstract translation: 公开了具有降低的过敏原性的橡胶胶乳组合物。 还公开了具有降低的变应原性的橡胶胶乳组合物的制造方法。
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公开(公告)号：US07935658B2
公开(公告)日：2011-05-03
申请号：US11906939
申请日：2007-10-04
Applicant: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
Inventor： Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
IPC: C40B30/10
CPC classification number: C07H21/00 , C12N15/1068 , C40B50/10
Abstract: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety which comprises n building blocks which comprise at least one reactive group, which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide which identifies the structure of the functional moiety.
Abstract translation: 本发明提供合成文库的方法，所述分子文库包括与编码寡核苷酸有效连接的功能部分。 方法通常包括提供包含引发剂化合物的溶液，其包含初始功能部分，其包含n个构建块，其包含至少一个与初始寡核苷酸有效连接的反应性基团; 将溶液分解成反应容器; 使每个反应容器中的引发剂化合物与包含互补反应性基团的构建块反应形成共价键; 并且在适合于引入寡核苷酸和初始寡核苷酸的酶连接的条件下，在催化引入的寡核苷酸和初始寡核苷酸的连接的酶存在下，使各等分试样中的初始寡核苷酸与不同的入侵寡核苷酸反应，形成编码 识别功能部分结构的寡核苷酸。
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公开(公告)号：US20100120771A1
公开(公告)日：2010-05-13
申请号：US12375164
申请日：2007-07-27
Applicant: Matthew Clark
Inventor： Matthew Clark
IPC: A61K31/53 , C07D403/14 , A61P35/00 , C12N9/99
CPC classification number: C07D471/04 , C07D251/54 , C07D401/12
Abstract: The present invention provides, at least in part, compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z1, Z2, Z3, R1, x, y, R2, R3, R4a, R4b, R5, R6 and R7 are described herein, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use as Aurora A kinase inhibitors in treatment, e.g., of cancer and other proliferative disorders.
Abstract translation: 本发明至少部分提供式（I）化合物或其药学上可接受的盐，其中Z1，Z2，Z3，R1，x，y，R2，R3，R4a，R4b，R5，R6和R7 以及它们的鉴定方法，其制备方法，含有它们的药物组合物，以及它们在治疗例如癌症和其它增殖性疾病中作为Aurora A激酶抑制剂的用途。
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