公开(公告)号：US11035202B2

公开(公告)日：2021-06-15

申请号：US15873759

申请日：2018-01-17

Applicant: Colin Andrew ,  Matthew Stone ,  Adam M. McGuire

Inventor： Colin Andrew ,  Matthew Stone ,  Adam M. McGuire

IPC: E21B34/14 ,  E21B34/12 ,  E21B43/12 ,  E21B34/08 ,  E21B34/10 ,  E21B33/127 ,  E21B17/20

Abstract: A substance deposition and backflow preventing arrangement including a housing having a port therein, a sleeve disposed within the housing and positionable to cover or uncover the port, the sleeve having a first seal at one end thereof presenting a first hydraulic dimension and a second seal at another end of the sleeve having a different hydraulic dimension, a biasing member operably connected to the sleeve and to the housing and configured to urge the sleeve to a position covering the port.

公开(公告)号：US10900311B2

公开(公告)日：2021-01-26

申请号：US16046823

申请日：2018-07-26

Applicant: YingQing Xu ,  Michael Johnson ,  Matthew Stone ,  Colin Andrew ,  Zhiyue Xu

Inventor： YingQing Xu ,  Michael Johnson ,  Matthew Stone ,  Colin Andrew ,  Zhiyue Xu

IPC: E21B29/02 ,  E21B43/26 ,  E21B33/12 ,  E21B1/02

Abstract: An object removal enhancement arrangement including a second object comprising a material configured to enhance degradation of a first object. A resource recovery system including a tubular string disposed in a formation, a first seat disposed in the tubular string, a second seat disposed in the tubular string, an object receivable in the second seat upstream of the first seat, the object comprising a material to enhance degradation of an object receivable in the first seat. A method for enhancing response time for degrading degradable objects in a system including landing a first object on a first seat, pressuring against the first object, landing a second object on a second seat uphole of the first object, releasing a material of the second object to an environment between the first seat and the second seat.

公开(公告)号：US10767429B2

公开(公告)日：2020-09-08

申请号：US16109531

申请日：2018-08-22

Applicant: Adam McGuire ,  Matthew Stone

Inventor： Adam McGuire ,  Matthew Stone

IPC: E21B21/10 ,  E21B34/14 ,  E21B33/12

Abstract: A plug bypass tool including a housing defining a main flow passage and a bypass passageway, the bypass passageway extending between a first port and a second port, the first and second ports being fluidly connected to the main flow passage, a first seat and a first sleeve disposed within the passage between the first port and second port, and a second seat and a second sleeve disposed in the passage, the second sleeve movable between a position covering the second port and a position revealing the second port.

公开(公告)号：US20190314206A1

公开(公告)日：2019-10-17

申请号：US15951311

申请日：2018-04-12

Applicant: Ryan Bruce Anderson ,  Bradley Yost ,  Matthew Stone ,  Tiffany Lei

Inventor： Ryan Bruce Anderson ,  Bradley Yost ,  Matthew Stone ,  Tiffany Lei

IPC: A61F11/14 ,  H04R1/10

Abstract: An acoustic metamaterial aural protection device ear cup which includes a dome having an opening, an interchangeable membrane stretched across the opening of the dome such that an airtight cavity is created, and a one-way vacuum valve; the valve is mounted to the dome, such that air can be removed from the cavity such that the membrane acts as an acoustic metamaterial, resulting in higher attenuation values at different frequencies.

公开(公告)号：US08632771B2

公开(公告)日：2014-01-21

申请号：US11696579

申请日：2007-04-04

Applicant: Gary L. Nelsestuen ,  Ronald Bach ,  Matthew Stone ,  Stephen Barrett Harvey

Inventor： Gary L. Nelsestuen ,  Ronald Bach ,  Matthew Stone ,  Stephen Barrett Harvey

IPC: A61K38/48

CPC classification number: A61K47/48215 ,  A61K38/00 ,  A61K47/60 ,  C12N9/6437 ,  C12N9/647 ,  C12Y304/21021

Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.

Abstract translation: 描述维生素K依赖性多肽的修饰，其导致在重量或摩尔基础上增强的蛋白质功能和/或循环中蛋白质寿命的增加。 这两个目标对于使用维生素K依赖多肽进行促凝和抗凝治疗以及循环中的其他用途都很重要。

公开(公告)号：US10822901B2

公开(公告)日：2020-11-03

申请号：US16047923

申请日：2018-07-27

Applicant: YingQing Xu ,  Michael Johnson ,  Matthew Stone ,  Colin Andrew ,  Zhiyue Xu

Inventor： YingQing Xu ,  Michael Johnson ,  Matthew Stone ,  Colin Andrew ,  Zhiyue Xu

IPC: E21B23/04 ,  E21B34/14 ,  E21B34/08

Abstract: An object seat including a seat host having a seal bore therein, a seat body dimensioned to be receivable in the seal bore, the seat body having an object receptor. A method for carrying out a pressure operation in a borehole including seating an object on an object receptor of a seat body, the seat body disposed in a seat host, the seat host disposed in the borehole, pressuring against the object, and moving the seat body along an interface between the seat body and the seat host to create a fluid flow pathway through the seat body and seat host interface. A borehole system including a borehole in a formation, an object seat as in any prior embodiment disposed in the borehole.

公开(公告)号：US20200032605A1

公开(公告)日：2020-01-30

申请号：US16046823

申请日：2018-07-26

Applicant: YingQing Xu ,  Michael Johnson ,  Matthew Stone ,  Colin Andrew ,  Zhiyue Xu

Inventor： YingQing Xu ,  Michael Johnson ,  Matthew Stone ,  Colin Andrew ,  Zhiyue Xu

IPC: E21B29/02 ,  E21B43/26

Abstract: An object removal enhancement arrangement including a second object comprising a material configured to enhance degradation of a first object. A resource recovery system including a tubular string disposed in a formation, a first seat disposed in the tubular string, a second seat disposed in the tubular string, an object receivable in the second seat upstream of the first seat, the object comprising a material to enhance degradation of an object receivable in the first seat. A method for enhancing response time for degrading degradable objects in a system including landing a first object on a first seat, pressuring against the first object, landing a second object on a second seat uphole of the first object, releasing a material of the second object to an environment between the first seat and the second seat.

公开(公告)号：US20190338617A1

公开(公告)日：2019-11-07

申请号：US15969599

申请日：2018-05-02

Applicant: Matthew Stone ,  Michael Johnson ,  Colin Andrew

Inventor： Matthew Stone ,  Michael Johnson ,  Colin Andrew

IPC: E21B33/12 ,  E21B34/06

Abstract: A plug seat including a body having a lead in and a tooth, a flow feature disposed at the body, the feature providing fluid access directly to an area immediately adjacent the tooth. A plug seat including a tooth positioned relative to a body to be at an upstream most end of the body, a cage extending from the body immediately downstream of the tooth to an area radially outward of the tooth and upstream thereof.

公开(公告)号：US20190153815A1

公开(公告)日：2019-05-23

申请号：US16178976

申请日：2018-11-02

Applicant: Matthew Stone ,  Herb Dhuet ,  Colin Andrew ,  Crystal Lowe

Inventor： Matthew Stone ,  Herb Dhuet ,  Colin Andrew ,  Crystal Lowe

IPC: E21B34/10 ,  E21B43/26

CPC classification number: E21B34/10 ,  E21B34/14 ,  E21B43/26 ,  E21B2034/002

Abstract: A method of controlling degradation of a degradable material including forming a fluid in a hydration unit, admixing one or more additives to the fluid in a blender, introducing the fluid into a wellbore, injecting a degradation fluid between the hydration unit and the blender. The degradation fluid forms a degradation zone in the fluid. A degradable component formed from a degradable material is introduced into the degradation zone, and the degradable material and the degradation zone is pumped into a wellbore.

公开(公告)号：US20120029176A1

公开(公告)日：2012-02-02

申请号：US13191992

申请日：2011-07-27

Applicant: David Yavorsky ,  John Amara ,  Joaquin Umana ,  William Cataldo ,  Mikhail Kozlov ,  Matthew Stone

Inventor： David Yavorsky ,  John Amara ,  Joaquin Umana ,  William Cataldo ,  Mikhail Kozlov ,  Matthew Stone

IPC: B01D15/08 ,  B01D15/10 ,  B01D15/36 ,  C07K1/20 ,  B01D15/32 ,  C07K1/22 ,  C07K1/18 ,  B01D15/04 ,  B01D15/38

CPC classification number: B01J39/26 ,  B01D15/327 ,  B01D15/361 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3804 ,  B01J20/28023 ,  B01J20/28059 ,  B01J20/285 ,  B01J20/287 ,  B01J20/3244 ,  B01J41/20 ,  B01J47/014 ,  B01J47/127 ,  C07K1/18 ,  C07K16/00 ,  C12N7/00 ,  C12N7/02 ,  G01N2030/521 ,  Y10S502/52724 ,  Y10T428/2938 ,  Y10T428/2973

Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

Abstract translation: 来自成形纤维的用于色谱的吸附介质，特别是离子交换层析。 在某些实施方案中，与普通纤维相比，功能化成形纤维呈现原纤化或脊状结构，其大大增加了纤维的表面积。 本文还公开了一种向高表面积纤维添加提供阳离子交换或阴离子交换官能团的表面侧基官能团的方法。 这种侧链官能团可用于生物分子的离子交换色谱纯化，如单克隆抗体（mAb）。