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公开(公告)号：US10960104B2
公开(公告)日：2021-03-30
申请号：US16289475
申请日：2019-02-28
Applicant: MediBeacon Inc.
Inventor： Bob O. Basore , William L. Neumann , Richard B. Dorshow , Raghavan Rajagopalan
Abstract: The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.
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Patent Agency Ranking
公开(公告)号：US10881759B2
公开(公告)日：2021-01-05
申请号：US15223240
申请日：2016-07-29
Applicant: MediBeacon Inc.
Inventor： Bob O. Basore , William L. Neumann , Richard B. Dorshow , Raghavan Rajagopalan
Abstract: The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.
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公开(公告)号：US20190192727A1
公开(公告)日：2019-06-27
申请号：US16289469
申请日：2019-02-28
Applicant: MediBeacon Inc.
Inventor： Bob O. Basore , William L. Neumann , Richard B. Dorshow , Raghavan Rajagopalan
CPC classification number: A61L24/102 , A61L24/001 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/106 , A61L24/108 , A61L2300/418 , A61L2300/442 , A61L2300/604 , A61L2400/04 , A61L2430/20 , A61L2430/34
Abstract: The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.
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公开(公告)号：US10967096B2
公开(公告)日：2021-04-06
申请号：US16289469
申请日：2019-02-28
Applicant: MediBeacon Inc.
Inventor： Bob O. Basore , William L. Neumann , Richard B. Dorshow , Raghavan Rajagopalan
Abstract: The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.
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公开(公告)号：US20190192728A1
公开(公告)日：2019-06-27
申请号：US16289475
申请日：2019-02-28
Applicant: MediBeacon Inc.
Inventor： Bob O. Basore , William L. Neumann , Richard B. Dorshow , Raghavan Rajagopalan
CPC classification number: A61L24/102 , A61L24/001 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/106 , A61L24/108 , A61L2300/418 , A61L2300/442 , A61L2300/604 , A61L2400/04 , A61L2430/20 , A61L2430/34
Abstract: The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.
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6.发明申请公开(公告)号：US20160331862A1
公开(公告)日：2016-11-17
申请号：US15223240
申请日：2016-07-29
Applicant: MediBeacon Inc.
Inventor： Bob O. Basore , William L. Neumann , Richard B. Dorshow , Raghavan Rajagopalan
Abstract: The present invention provides tissue sealant compositions and vasculature closure devices useful for the optical detection of tissue seal and/or clot formation. Compositions and devices of the present invention comprise optical dyes which undergo an observable change as the compositions and/or devices are incorporated into a tissue seal and/or clot, for example a change in fluorescence quantum yield and/or a change in visual color including a change in emission and/or absorption wavelength. Tissue sealants and vasculature closure devices of the present invention are useful for visualizing seal and/or clot formation, for example, during or after surgical procedures, after catheter removal, etc. The present invention further provides methods for formation and optical detection of tissue seals or vasculature puncture closures as well as medical kits useful for the formation and optical detection of tissue seals or vasculature puncture closures.
Abstract translation: 本发明提供组织密封剂组合物和脉管系统闭合装置，其可用于光学检测组织密封和/或凝块形成。 本发明的组合物和装置包括当组合物和/或装置结合到组织密封和/或凝块中时经历可观察到的变化的光学染料，例如荧光量子产率的变化和/或视觉颜色的变化，包括 发射和/或吸收波长的变化。 本发明的组织密封剂和血管闭合装置可用于可视化密封和/或血块形成，例如，在外科手术期间或之后，导管移除之后等。本发明还提供用于组织密封的形成和光学检测的方法 或脉管系统穿刺闭合件以及可用于组织密封或脉管系统穿刺闭合件的形成和光学检测的医疗套件。
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