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    Method of Fabricating an Array of Capillaries on a Chip
    1.
    发明申请
    Method of Fabricating an Array of Capillaries on a Chip 审中-公开
    在芯片上制造毛细管阵列的方法

    公开(公告)号：US20090054264A1

    公开(公告)日：2009-02-26

    申请号：US12224423

    申请日：2007-02-26

    Applicant: Nicolas Ugolin ,  Pascal Wodling ,  Julien Le Meur ,  Pierre-Yves Tro ,  Sylvie Chevillard

    Inventor： Nicolas Ugolin ,  Pascal Wodling ,  Julien Le Meur ,  Pierre-Yves Tro ,  Sylvie Chevillard

    IPC: C40B40/00 ,  C40B50/18 ,  C40B60/12

    CPC classification number: B01L3/502707 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887

    Abstract: The invention relates to a method of fabricating an array of capillaries of a chip, the method comprising the steps consisting in depositing at least one layer of a meltable or polymerizable construction material on a support plate, focusing and moving a laser beam on and over said layer respectively to melt or polymerize the material so as to form the side walls of the capillaries, and then fastening a cover plate on the side walls of the capillaries. The invention also provides a chip including an array of capillaries in which chemical or biological molecules are fixed, and a chip including an array of chromatography and/or electrophoresis capillaries.

    Abstract translation: 本发明涉及一种制造芯片的毛细管阵列的方法，该方法包括以下步骤：在支撑板上沉积至少一层可熔化或可聚合的建筑材料，聚焦并移动所述的 层以熔化或聚合材料以形成毛细管的侧壁，然后将盖板紧固在毛细管的侧壁上。 本发明还提供一种芯片，其包括固定有化学或生物分子的毛细管阵列，以及包括色谱和/或电泳毛细管阵列的芯片。

    METHOD FOR THE DESALINATION OR PURIFICATION OF WATER BY DISTILLATION OF A SPRAY (SPRAY PUMP)
    2.
    发明申请
    METHOD FOR THE DESALINATION OR PURIFICATION OF WATER BY DISTILLATION OF A SPRAY (SPRAY PUMP) 有权
    通过喷雾（喷雾泵）蒸馏除水或净化水的方法

    公开(公告)号：US20110174605A1

    公开(公告)日：2011-07-21

    申请号：US13060131

    申请日：2009-08-20

    Applicant: Nicolas Ugolin

    Inventor： Nicolas Ugolin

    IPC: C02F1/14

    CPC classification number: B01D1/18 ,  B01D1/16 ,  B01D1/20 ,  C02F1/001 ,  C02F1/06 ,  C02F1/12 ,  C02F1/36 ,  C02F1/444 ,  Y02A20/128 ,  Y02A20/131 ,  Y02W10/37 ,  Y10S203/01 ,  Y10S203/11 ,  Y10S203/18

    Abstract: A system enables the use of solar heat energy together with electromagnetic energy and optionally energy produced during fermentation of organic products to produce fresh water from salt water, wastewater and water vapor contained in the atmosphere. The resulting fresh water can optionally be rendered drinkable by adding mineral salts at the desired concentration. A method and reactors combine electromagnetic and solar heating steps and optionally heat exchanges with a hot gas originating from combustion, to evaporate droplets of a spray produced from salt water or wastewater. The vapor obtained is separated from the salt particles or agglomerated impurities during evaporation using a cyclone system. The vapor can then be transported over a large distance before being condensed by bearings, in order to separate the water from any additives or impurities that may be present. Additives can be used to lower the vapor pressure of the liquid water and to facilitate droplet fractionation.

    Abstract translation: 一种系统能够将太阳能热能与电磁能一起使用，并且可选地在有机产物的发酵期间产生的能量，以从大气中的盐水，废水和水蒸汽中产生淡水。 所得淡水可任选地通过以所需浓度加入矿物盐而变得可饮用。 一种方法和反应器结合电磁和太阳能加热步骤以及任选地与来自燃烧的热气体进行热交换，以蒸发由盐水或废水产生的喷雾的液滴。 使用旋风系统在蒸发期间将所得的蒸气与盐颗粒或附聚杂质分离。 然后可以在通过轴承冷凝之前将蒸气输送很大的距离，以便将水与可能存在的任何添加剂或杂质分离。 可以使用添加剂来降低液态水的蒸汽压力并促进液滴分馏。

    Device for separating and/or analyzing several molecular targets dissolved in a complex mixture
    4.
    发明授权
    Device for separating and/or analyzing several molecular targets dissolved in a complex mixture 失效
    用于分离和/或分析溶解在复杂混合物中的若干分子靶的装置

    公开(公告)号：US07687257B2

    公开(公告)日：2010-03-30

    申请号：US11386781

    申请日：2006-03-23

    Applicant: Nicolas Ugolin ,  Sylvie Chevillard ,  Catherine Ory ,  Jerome Lebeau

    Inventor： Nicolas Ugolin ,  Sylvie Chevillard ,  Catherine Ory ,  Jerome Lebeau

    IPC: C12M1/34

    CPC classification number: B01L3/502715 ,  B01L3/502761 ,  B01L2300/0819 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0478 ,  G01N1/405 ,  G01N27/44773 ,  G01N27/44782

    Abstract: The invention relates to a device for separating and/analyzing several molecular targets dissolved in a complex mixture which is characterized in that it comprises a) a matrix of micro-columns, wherein each micro-column (2) comprises an immobilized molecular probe for retaining a specific molecular target contained in the complex mixture by specific probe/target linkage, b) a first capillary network (3) for circulating the complex mixture introduced into the inventive device towards each micro-column of the matrix defined in a), c) a second capillary network (4) for circulating, after elution, the molecular targets retained on the micro-columns towards a sensor (5) for carrying out the recovery and/or analysis thereof, and d) if necessary, a sensor (5), preferably in the form of a mass spectrometer, for carrying out the recovery and/or analysis of different molecular targets.

    Abstract translation: 本发明涉及用于分离和/分析溶解在复合混合物中的几种分子靶的装置，其特征在于其包括a）微柱基质，其中每个微柱（2）包含固定的分子探针，用于保留 通过特异性探针/靶连接物包含在复合物混合物中的特定分子靶，b）用于将引入本发明装置的复合物混合物循环到a），（c）中定义的基质的每个微柱的第一毛细管网（3） 第二毛细管网络（4），用于在洗脱后使保留在微柱上的分子靶朝向传感器（5）循环，用于进行其回收和/或分析，以及d）如果需要，传感器（5） ，优选以质谱仪的形式，用于进行不同分子靶标的回收和/或分析。

    Device for separating and/or analyzing several molecular targets dissolved in a complex mixture
    5.
    发明申请
    Device for separating and/or analyzing several molecular targets dissolved in a complex mixture 失效
    用于分离和/或分析溶解在复杂混合物中的若干分子靶的装置

    公开(公告)号：US20060239864A1

    公开(公告)日：2006-10-26

    申请号：US11386781

    申请日：2006-03-23

    Applicant: Nicolas Ugolin ,  Sylvie Chevillard ,  Catherine Ory ,  Jerome Lebeau

    Inventor： Nicolas Ugolin ,  Sylvie Chevillard ,  Catherine Ory ,  Jerome Lebeau

    IPC: G01N1/00

    CPC classification number: B01L3/502715 ,  B01L3/502761 ,  B01L2300/0819 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0478 ,  G01N1/405 ,  G01N27/44773 ,  G01N27/44782

    Abstract: The invention relates to a device for separating and/analyzing several molecular targets dissolved in a complex mixture which is characterized in that it comprises a) a matrix of micro-columns, wherein each micro-column (2) comprises an immobilized molecular probe for retaining a specific molecular target contained in the complex mixture by specific probe/target linkage, b) a first capillary network (3) for circulating the complex mixture introduced into the inventive device towards each micro-column of the matrix defined in a), c) a second capillary network (4) for circulating, after elution, the molecular targets retained on the micro-columns towards a sensor (5) for carrying out the recovery and/or analysis thereof, and d) if necessary, a sensor (5), preferably in the form of a mass spectrometer, for carrying out the recovery and/or analysis of different molecular targets.

    Abstract translation: 本发明涉及用于分离和/分析溶解在复合混合物中的几种分子靶的装置，其特征在于其包括a）微柱基质，其中每个微柱（2）包含固定的分子探针，用于保留 通过特异性探针/靶连接物包含在复合物混合物中的特定分子靶，b）用于将引入本发明装置的复合物混合物循环到a），（c）中定义的基质的每个微柱的第一毛细管网（3） 第二毛细管网络（4），用于在洗脱后使保留在微柱上的分子靶朝向传感器（5）循环，用于进行其回收和/或分析，以及d）如果需要，传感器（5） ，优选以质谱仪的形式，用于进行不同分子靶标的回收和/或分析。

    Method for the desalination or purification of water by distillation of a spray (spray pump)
    6.
    发明授权
    Method for the desalination or purification of water by distillation of a spray (spray pump) 有权
    通过喷雾（喷雾泵）蒸馏脱盐或净化水的方法

    公开(公告)号：US08906203B2

    公开(公告)日：2014-12-09

    申请号：US13060131

    申请日：2009-08-20

    Applicant: Nicolas Ugolin

    Inventor： Nicolas Ugolin

    IPC: C02F1/12 ,  C02F1/14 ,  B01D1/14 ,  B01D1/16 ,  B01D3/00 ,  B05D1/00 ,  B01D1/18 ,  B01D1/20 ,  C02F1/06 ,  C02F1/00 ,  C02F1/36 ,  C02F1/44

    CPC classification number: B01D1/18 ,  B01D1/16 ,  B01D1/20 ,  C02F1/001 ,  C02F1/06 ,  C02F1/12 ,  C02F1/36 ,  C02F1/444 ,  Y02A20/128 ,  Y02A20/131 ,  Y02W10/37 ,  Y10S203/01 ,  Y10S203/11 ,  Y10S203/18

    Abstract: A system enables the use of solar heat energy together with electromagnetic energy and optionally energy produced during fermentation of organic products to produce fresh water from salt water, wastewater and water vapor contained in the atmosphere. The resulting fresh water can optionally be rendered drinkable by adding mineral salts at the desired concentration. A method and reactors combine electromagnetic and solar heating steps and optionally heat exchanges with a hot gas originating from combustion, to evaporate droplets of a spray produced from salt water or wastewater. The vapor obtained is separated from the salt particles or agglomerated impurities during evaporation using a cyclone system. The vapor can then be transported over a large distance before being condensed by bearings, in order to separate the water from any additives or impurities that may be present. Additives can be used to lower the vapor pressure of the liquid water and to facilitate droplet fractionation.

    Abstract translation: 一种系统能够将太阳能热能与电磁能一起使用，并且可选地在有机产物的发酵期间产生的能量，以从大气中的盐水，废水和水蒸汽中产生淡水。 所得淡水可任选地通过以所需浓度加入矿物盐而变得可饮用。 一种方法和反应器结合电磁和太阳能加热步骤以及任选地与来自燃烧的热气体进行热交换，以蒸发由盐水或废水产生的喷雾的液滴。 使用旋风系统在蒸发期间将所得的蒸气与盐颗粒或附聚杂质分离。 然后可以在通过轴承冷凝之前将蒸气输送很大的距离，以便将水与可能存在的任何添加剂或杂质分离。 可以使用添加剂来降低液态水的蒸汽压力并促进液滴分馏。

    METHOD FOR THE QUANTITATIVE MEASUREMENT OF BIOMOLECULAR TARGETS DEPOSITED ON A BIOCHIP, AND DEVICE FOR IMPLEMENTING IT
    8.
    发明申请
    METHOD FOR THE QUANTITATIVE MEASUREMENT OF BIOMOLECULAR TARGETS DEPOSITED ON A BIOCHIP, AND DEVICE FOR IMPLEMENTING IT 有权
    生物分子量目标定量测定方法，以及生物分子实验装置

    公开(公告)号：US20100022400A1

    公开(公告)日：2010-01-28

    申请号：US12441225

    申请日：2007-09-14

    Applicant: Nicolas Ugolin ,  Denis Menut ,  Julien Le Meur ,  Pascal Wodling ,  Sylvie Chevillard

    Inventor： Nicolas Ugolin ,  Denis Menut ,  Julien Le Meur ,  Pascal Wodling ,  Sylvie Chevillard

    IPC: C40B30/00 ,  C40B60/12

    CPC classification number: G01N21/718 ,  B33Y80/00

    Abstract: The present invention relates in particular to a method for the quantitative measurement of biomolecular targets that have been deposited on a biochip (1) of the type with a matrix of probes hybridized by the targets, the matrix comprising a multitude of measurement points (2) each comprising a plurality of probes, characterized in that it comprises the following steps: a) at least one laser beam (18) is focused onto each measurement point, in order to extract therefrom a hot confined plasma comprising a chemical element to be quantified that is present in the targets and optionally in the probes; b) the light emission lines from the plasma are detected and analysed for each measurement point, by measuring the respective intensities of these lines; and then c) the concentration in each measurement point of the element or of a group incorporating it within the targets is determined via a prior calibration of the lines establishing a correlation between the intensities of the lines specific to the element to be quantified and given concentrations of this element.

    Abstract translation: 本发明特别涉及一种用于定量测量生物分子靶标的方法，该方法已经沉积在具有由靶标杂交的探针基质的类型的生物芯片（1）上，该基质包含多个测量点（2） 每个包括多个探针，其特征在于，其包括以下步骤：a）至少一个激光束（18）聚焦到每个测量点上，以便从其中提取包含要量化的化学元素的热限制等离子体， 存在于目标物中，任选地存在于探针中; b）通过测量这些线的相应强度，对每个测量点检测和分析来自等离子体的发光线; 然后c）通过先前校准线确定要量化的元素和给定浓度的特异性线之间的相关性来确定元件或其中包含在靶中的组的每个测量点中的浓度 的元素。

    Image analysis process for measuring the signal on biochips
    9.
    发明授权
    Image analysis process for measuring the signal on biochips 失效
    用于测量生物芯片上信号的图像分析过程

    公开(公告)号：US07136517B2

    公开(公告)日：2006-11-14

    申请号：US10173672

    申请日：2002-06-19

    Applicant: Nicolas Ugolin ,  Mory Doukoure ,  Olivier Alibert ,  Sylvie Chevillard

    Inventor： Nicolas Ugolin ,  Mory Doukoure ,  Olivier Alibert ,  Sylvie Chevillard

    IPC: G06K9/00

    CPC classification number: G06T1/0007 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/20056 ,  G06T2207/30072

    Abstract: The invention relates to an image analysis process for measuring the signal on biochips organized into one or several blocks each comprising a large number of spots each composed of at least one probe, the said process being characterized in that it comprises the following steps: a deposit is made with a constant pitch, the spots appearing in the form of a periodic and regular signal; this periodicity property is used to identify the position of the blocks and the spots, this periodicity being searched for on projections of the image in the x and y directions.

    Abstract translation: 本发明涉及一种用于测量组织成一个或多个块的生物芯片上的信号的图像分析过程，每个块包括大量由至少一个探针组成的点，所述方法的特征在于其包括以下步骤：沉积物 以恒定音调制成，斑点以周期性和规则信号的形式出现; 该周期特性用于识别块和斑点的位置，在x和y方向上的图像的投影上搜索该周期。

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