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公开(公告)号：US20190177460A1
公开(公告)日：2019-06-13
申请号：US16278304
申请日：2019-02-18
Applicant: Novartis AG
Inventor： Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08F290/06 , C08G77/392 , C08G77/16 , G02B1/04 , C08G77/20
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US20180113237A1
公开(公告)日：2018-04-26
申请号：US15792807
申请日：2017-10-25
Applicant: Novartis AG
Inventor： Frank Chang , Feng Jing , Fei Cheng , Ying Zheng
CPC classification number: G02B1/043 , B29D11/00038 , B29D11/00134 , C08F283/122 , C08F285/00 , C08F290/142 , C08F299/08 , C08G77/20 , C08G77/28 , C08G2210/00 , C08J3/075 , C08J3/247 , C08J2383/08 , C08L25/06 , C08L33/10 , C08L83/08 , C08L2205/02 , C08L83/04 , C08F2222/108 , C08F2220/286 , C08F226/10
Abstract: The invention provides a class of amphiphilic branched polydiorganosiloxane macromers and the uses thereof. Such a macromer comprises a polydiorganosiloxane polymer chain and two terminal groups free of any ethylenically unsaturated group, wherein the polydiorganosiloxane polymer chain comprises (1) at least 5 dimethylsiloxane units in a consecutive sequence, (2) at least two first siloxane units each having methyl as one of the two substituents of each first siloxane unit and one first first organic radical having one sole (meth)acryloyl group as the other substituent, (3) at least one second siloxane unit having methyl as one of the two substituents of the second siloxane unit and one second organic radical, which is free of any ethylenically unsaturated group and comprises one or more hydrophilic groups or polymer chains, as the other substituent.
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公开(公告)号：US20170166673A1
公开(公告)日：2017-06-15
申请号：US15376700
申请日：2016-12-13
Applicant: Novartis AG
Inventor： Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08F290/06 , C08G77/20 , G02B1/04
CPC classification number: C08F290/068 , C08G77/12 , C08G77/16 , C08G77/20 , C08G77/392 , G02B1/043 , C08L83/04 , C08L101/14
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US10301451B2
公开(公告)日：2019-05-28
申请号：US15727666
申请日：2017-10-09
Applicant: Novartis AG
Inventor： Feng Jing , Frank Chang
IPC: C08G77/14 , C08K5/00 , C08K5/5419 , C08G77/20 , C08G77/392 , C08G77/38 , C08G77/388 , G02C7/04
Abstract: The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising a chain-extended polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US10246543B2
公开(公告)日：2019-04-02
申请号：US16110194
申请日：2018-08-23
Applicant: Novartis AG
Inventor： Jinyu Huang , Frank Chang , Steve Yun Zhang , Feng Jing
IPC: C08L101/14 , C08L83/04 , C08F290/06 , C08G77/20 , C08G77/16 , C08G77/392 , G02B1/04 , C08G77/12
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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Patent Agency Ranking
公开(公告)号：US20180105620A1
公开(公告)日：2018-04-19
申请号：US15730785
申请日：2017-10-12
Applicant: Novartis AG
Inventor： Frank Chang , Troy Vernon Holland , Feng Jing , Ryan DeSousa
CPC classification number: C08F28/02 , C08B37/0063 , C08F8/30 , C08F8/34 , C08F8/48 , C08F20/56 , C08F24/00 , C08F26/06 , C08F2810/20 , G02B1/04 , G02B1/043 , G02C7/04 , C08F216/06 , C08F220/36 , C08F216/38 , C08L1/00 , C08L29/04 , C08L37/00
Abstract: The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.
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公开(公告)号：US10920099B2
公开(公告)日：2021-02-16
申请号：US16036988
申请日：2018-07-17
Applicant: Novartis AG
Inventor： Frank Chang , Feng Jing , Troy Vernon Holland , Chung-Yuan Chiang , John Dallas Pruitt
IPC: C09D133/26 , C08L33/26 , C08L79/02 , C09D179/02 , C08F220/28 , C08F220/38 , C08F220/56 , C09D5/02 , C09D133/14 , C09D179/08 , G02B1/04
Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.
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公开(公告)号：US20190023891A1
公开(公告)日：2019-01-24
申请号：US16036983
申请日：2018-07-17
Applicant: Novartis AG
Inventor： Frank Chang , Feng Jing , Troy Vernon Holland , Chung-Yuan Chiang , John Dallas Pruitt
Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.
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公开(公告)号：US20180100038A1
公开(公告)日：2018-04-12
申请号：US15727674
申请日：2017-10-09
Applicant: Novartis AG
Inventor： Feng Jing , Frank Chang
IPC: C08G77/442 , C08G77/38 , C08F299/08 , C08F26/10 , C08F20/06 , G02C7/04
CPC classification number: C08G77/442 , C08F20/06 , C08F26/10 , C08F299/08 , C08F2800/20 , C08G77/20 , C08G77/38 , C08G77/46 , C08G2210/00 , G02C7/049
Abstract: The invention provides a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer which comprises (1) a linear polymer chain comprising at least two polydimethylsiloxane segments, one hydrophilic polyoxyalkylene segment between each pair of polydimethylsiloxane segments, and one amide-rich linker between each pair of one polydimethylsiloxane segment and one hydrophilic polyoxyalkylene segment, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a weight average molecular weight of at least 3000 Daltons. The invention is also related to a silicone hydrogel contact lens produced from a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer of the invention.
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公开(公告)号：US10676608B2
公开(公告)日：2020-06-09
申请号：US16036983
申请日：2018-07-17
Applicant: Novartis AG
Inventor： Frank Chang , Feng Jing , Troy Vernon Holland , Chung-Yuan Chiang , John Dallas Pruitt
Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.
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