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    Ophthalmic devices for delivery of hydrophobic comfort agents
    1.
    发明授权
    Ophthalmic devices for delivery of hydrophobic comfort agents 有权

    公开(公告)号：US10913224B2

    公开(公告)日：2021-02-09

    申请号：US16181763

    申请日：2018-11-06

    Applicant: Novartis AG

    Inventor： John Dallas Pruitt ,  Lynn Cook Winterton ,  Jared Nelson

    IPC: A61K9/00 ,  G02B1/04 ,  B29D11/00

    Abstract: The invention relates to a soft hydrogel contact lens, especially a silicone hydrogel contact lens, which has a capability of delivering a hydrophobic comfort agent into the eye of a wearer. The hydrophobic comfort agent includes without limitation a monoglyceride, a diglyceride, a triglyceride, a glycolipid, a glyceroglycolipid, a sphingolipid, a sphingo-glycolipid, a phospholipid, a fatty acid, a fatty alcohol, a hydrocarbon having a C12-C28 chain in length, a mineral oil, a silicone oil, or a mixture thereof. It can be released from the soft hydrogel contact lens into the eye of a wearer when being worn so as to strengthen and stabilize the tear film lipid layer and alleviate the dryness of the eye.

    Hydrogel contact lenses with lubricious coating thereon
    2.
    发明授权
    Hydrogel contact lenses with lubricious coating thereon 有权

    公开(公告)号：US10449739B2

    公开(公告)日：2019-10-22

    申请号：US15704205

    申请日：2017-09-14

    Applicant: Novartis AG

    Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Jared Nelson

    IPC: B29D11/00 ,  C08F20/00 ,  G02B1/04 ,  C08F220/20 ,  C08F220/58

    Abstract: The invention is generally related to soft contact lenses which comprise a non-silicone hydrogel lens body and a hydrogel coating thereon. The non-silicone hydrogel lens body is composed of a hydrogel material which is free of silicone and comprises at least 50% by mole of repeating units of at least one hydroxyl-containing vinylic monomer. The hydrogel coating comprises a first polymeric material having first reactive functional groups and a hydrogel layer derived from a second polymeric material having second reactive functional groups, and the hydrogel layer is covalently attached onto the anchor layer through linkages each formed between one first reactive functional group and one second reactive functional group. The soft contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and has a friction rating of about 2 or lower after 7 cycles of manual rubbing, a water content of from about 10% to about 85% by weight and an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated at room temperature.

    HYDROGEL CONTACT LENSES WITH LUBRICIOUS COATING THEREON
    3.
    发明申请
    HYDROGEL CONTACT LENSES WITH LUBRICIOUS COATING THEREON 审中-公开

    公开(公告)号：US20180079158A1

    公开(公告)日：2018-03-22

    申请号：US15704205

    申请日：2017-09-14

    Applicant: Novartis AG

    Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Jared Nelson

    IPC: B29D11/00 ,  G02B1/04 ,  C08F20/00

    CPC classification number: B29D11/00067 ,  B29D11/00038 ,  B29D11/00865 ,  B29D11/00923 ,  B29K2995/0092 ,  C08F20/00 ,  C08F220/20 ,  C08F220/58 ,  G02B1/043

    Abstract: The invention is generally related to soft contact lenses which comprise a non-silicone hydrogel lens body and a hydrogel coating thereon. The non-silicone hydrogel lens body is composed of a hydrogel material which is free of silicone and comprises at least 50% by mole of repeating units of at least one hydroxyl-containing vinylic monomer. The hydrogel coating comprises a first polymeric material having first reactive functional groups and a hydrogel layer derived from a second polymeric material having second reactive functional groups, and the hydrogel layer is covalently attached onto the anchor layer through linkages each formed between one first reactive functional group and one second reactive functional group. The soft contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and has a friction rating of about 2 or lower after 7 cycles of manual rubbing, a water content of from about 10% to about 85% by weight and an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated at room temperature.

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