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    INTRACANALICULAR INSERT COMPRISING A NON-STEROIDAL ANTI-INFLAMMATORY AGENT
    2.
    发明申请
    INTRACANALICULAR INSERT COMPRISING A NON-STEROIDAL ANTI-INFLAMMATORY AGENT 有权

    公开(公告)号：US20250064760A1

    公开(公告)日：2025-02-27

    申请号：US18726302

    申请日：2023-01-06

    Applicant: OCULAR THERAPEUTIX, INC.

    Inventor： Charles D. BLIZZARD ,  Ankita DESAI ,  Rami EL-HAYEK ,  Michael GOLDSTEIN ,  Peter JARRETT ,  Oktay UZUN

    IPC: A61K31/165 ,  A61K9/00

    Abstract: In certain embodiments, the invention relates to a sustained release biodegradable intracanalicular insert containing nepafenac dispersed in a hydrogel for the treatment of pain and inflammation. According to certain embodiments of the present invention, pain and inflammation is treated by administering a biodegradable insert into the superior and/or inferior canaliculus of the eye, wherein the insert provides sustained release of a nonsteroidal anti-inflammatory such as nepafenac that is effective for treating pain and inflammation in a patient, e.g., during a period of one or more weeks, with only a single administration, and without the need for removal of the drug-depleted insert.

    PRODRUGS OF AXITINIB
    5.
    发明申请
    PRODRUGS OF AXITINIB 有权

    公开(公告)号：US20250092013A1

    公开(公告)日：2025-03-20

    申请号：US18706306

    申请日：2022-10-14

    Applicant: OCULAR THERAPEUTIX, INC.

    Inventor： Peter JARRETT ,  Rami EL-HAYEK

    IPC: C07D401/06 ,  A61K31/4439

    Abstract: In certain embodiments, the invention is directed to a compound of formula I: wherein: X1 is selected from N or N+Y1; X2 is selected from NH or NY2; X3 is selected from NH or NY3; Y is selected from —CH2OCO(OCH2CH2)n1OM1; or —CH2OCO(CH2)n1aCOOH; Y2 is selected from —CH2OCO(OCH2CH2)n2OM2; or —CH2OCO(CH2)n2aCOOH; Y3 is selected from —CH2OCO(OCH2CH2)n3OM3; or —CH2OCO(CH2)n3aCOOH; n1, n1a n2a, n3 and n3a are independently 0 or an integer from 1 to 8; M1, M2 and M3 are independently selected from H, optionally substituted C1-6alkyl and optionally substituted aryl wherein at least one of X1, X2 and X3 is not N or NH; and pharmaceutically acceptable salts thereof.

    IMPLANT INJECTOR DEVICE
    6.
    发明公开
    IMPLANT INJECTOR DEVICE 审中-公开

    公开(公告)号：US20240041647A1

    公开(公告)日：2024-02-08

    申请号：US18282124

    申请日：2022-03-24

    Applicant: OCULAR THERAPEUTIX, INC.

    Inventor： Peter JARRETT ,  Erik WONG ,  Eric DICKINSON

    IPC: A61F9/00

    CPC classification number: A61F9/0017

    Abstract: A system (100) includes a first assembly (110A) and a second assembly (110B). The first assembly (110A) includes a body (120) forming a first interior volume, a plunger (130) comprising a first distal end disposed within the first interior volume, a wire comprising a first distal end secured to the first distal end of the plunger (130), and a plunger clip (140) configured to interface with the plunger (130) and the body (120) to prevent actuation of the plunger (130). The second assembly (110B) includes a cowl (150) forming a second interior volume, a needle comprising a hub and a shaft, and a cowl cap disposed partially within the hub to secure the implant in the shaft. A first distal end of the shaft is connected to the hub. The hub is disposed within the second interior volume. The shaft is configured to receive an implant.

    INTRACANALICULAR DEPOT INSERTER DEVICE
    7.
    发明申请
    INTRACANALICULAR DEPOT INSERTER DEVICE 有权

    公开(公告)号：US20240390183A1

    公开(公告)日：2024-11-28

    申请号：US18619321

    申请日：2024-03-28

    Applicant: OCULAR THERAPEUTIX, INC.

    Inventor： Peter JARRETT ,  Erik WONG

    IPC: A61F9/00

    Abstract: Disclosed in certain embodiments is an intracanalicular injectable applicator device includes a body forming a cavity and a cannula coupled to a first distal end of the body. The cannula forms a channel that is aligned with the cavity of the body. The cannula is configured to store an intracanalicular injectable in the channel. The intracanalicular injectable applicator device further includes a tip structure coupled to the body. The tip structure is disposed around at least a portion of the cannula. A distal end of the tip structure is configured to dilate a lacrimal punctum by inserting the distal end of the tip structure into the canaliculus via the lacrimal punctum. The intracanalicular injectable applicator device further includes an actuating structure configured to push the intracanalicular injectable through the channel and the distal end of the tip structure into a canaliculus via a lacrimal punctum.

    INTRACANALICULAR DEPOT INSERTER DEVICE
    8.
    发明公开
    INTRACANALICULAR DEPOT INSERTER DEVICE 审中-公开

    公开(公告)号：US20240082054A1

    公开(公告)日：2024-03-14

    申请号：US18278538

    申请日：2022-02-23

    Applicant: OCULAR THERAPEUTIX, INC.

    Inventor： Peter JARRETT ,  Erik WONG

    IPC: A61F9/00

    CPC classification number: A61F9/0017

    Abstract: Disclosed in certain embodiments is an intracanalicular injectable applicator device includes a body forming a cavity and a cannula coupled to a first distal end of the body. The cannula forms a channel that is aligned with the cavity of the body. The cannula is configured to store an intracanalicular injectable in the channel. The intracanalicular injectable applicator device further includes a tip structure coupled to the body. The tip structure is disposed around at least a portion of the cannula. A distal end of the tip structure is configured to dilate a lacrimal punctum by inserting the distal end of the tip structure into the canaliculus via the lacrimal punctum. The intracanalicular injectable applicator device further includes an actuating structure configured to push the intracanalicular injectable through the channel and the distal end of the tip structure into a canaliculus via a lacrimal punctum.

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