公开(公告)号：US20190350507A1

公开(公告)日：2019-11-21

申请号：US16271653

申请日：2019-02-08

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  G16H20/17 ,  A61M5/172 ,  A61B5/00 ,  A61M39/10 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61B5/155 ,  A61B5/15 ,  G01N21/03 ,  G01N21/07 ,  G01N33/49 ,  A61B5/1459

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US09554742B2

公开(公告)日：2017-01-31

申请号：US14589867

申请日：2015-01-05

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: G01N33/48 ,  A61B5/157 ,  A61B5/1455 ,  A61B5/15 ,  G01N33/49 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/153 ,  G01N21/03 ,  G01N21/07 ,  A61M5/172 ,  G06F19/00 ,  A61M5/142 ,  G01N21/35 ,  A61M5/14 ,  A61M5/168

CPC classification number: A61B5/157 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/6866 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

Abstract translation: 公开了用于确定流体（例如血液）中分析物浓度的系统和方法。 该系统可以从患者抽取血液并将血液输送到样品池。 流体（例如，等离子体）的特定组分可以被分离和/或定位，使得在流体的特定组分（例如，等离子体）中测量分析物的浓度。 样品池可以包括具有两个窗件的样品容器。 该系统可以具有流体通道，其具有构造成与多腔导管配合而不泄漏的顶端。 多腔导管可以具有近端和远端端口。 流体压力系统可以被配置成周期性地从脉管系统中抽取流体通过近端血管内开口和近端口，同时保持低压和/或流速，从而降低反转容器中的流体流动的风险，并将输注物上游到另一个 血管内开放。

公开(公告)号：US10660557B2

公开(公告)日：2020-05-26

申请号：US16271653

申请日：2019-02-08

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61B5/155 ,  A61M39/10 ,  A61B5/15 ,  A61B5/1459 ,  A61M5/172 ,  G01N21/03 ,  G01N21/07 ,  G01N33/49 ,  G06F19/00 ,  G16H20/17 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US10201303B2

公开(公告)日：2019-02-12

申请号：US15418485

申请日：2017-01-27

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61M39/10 ,  A61B5/15 ,  A61B5/1459 ,  A61M5/172 ,  G01N21/03 ,  G01N21/07 ,  G01N33/49 ,  G06F19/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US20170296112A1

公开(公告)日：2017-10-19

申请号：US15418485

申请日：2017-01-27

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/15 ,  A61B5/153 ,  A61B5/155 ,  G01N33/49 ,  G01N21/07 ,  G01N21/03 ,  A61M5/172 ,  G06F19/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

CPC classification number: A61B5/157 ,  A61B5/0059 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/412 ,  A61B5/6866 ,  A61B2560/0228 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M39/10 ,  A61M39/1011 ,  A61M2005/14208 ,  A61M2039/1033 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US20150119663A1

公开(公告)日：2015-04-30

申请号：US14589867

申请日：2015-01-05

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/15 ,  A61B5/1455

CPC classification number: A61B5/157 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/6866 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

Abstract translation: 公开了用于确定流体（例如血液）中分析物浓度的系统和方法。 该系统可以从患者抽取血液并将血液输送到样品池。 流体（例如，等离子体）的特定组分可以被分离和/或定位，使得在流体的特定组分（例如，等离子体）中测量分析物的浓度。 样品池可以包括具有两个窗件的样品容器。 该系统可以具有流体通道，其具有构造成与多腔导管配合而不泄漏的顶端。 多腔导管可以具有近端和远端端口。 流体压力系统可以被配置成周期性地从脉管系统中抽取流体通过近端血管内开口和近端口，同时保持低压和/或流速，从而降低反转容器中的流体流动的风险，并将输注物上游到另一个 血管内开放。

公开(公告)号：US20200227144A1

公开(公告)日：2020-07-16

申请号：US16680468

申请日：2019-11-11

Applicant: OptiScan Biomedical Corporation

Inventor： David N. Callicoat ,  Monnett H. Soldo

IPC: G16C99/00 ,  G01N33/66 ,  G16B99/00

Abstract: Examples of methods and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. In one example, the method can reduce the error in the estimation of analyte concentration in the presence of interferents. The method can include the use of one or more calibration set to determine analyte concentration. From a sample measurement, each calibration set can be tested to determine if it is eligible to estimate the analyte concentration in the sample. An estimate of analyte concentration can then be produced, based at least in part on the eligible calibration sets and on the sample measurement. In some implementations, if no calibration sets are eligible, an action is taken such as not outputting an estimate, displaying an alarm or alert, or providing a notification.

公开(公告)号：US20180263555A1

公开(公告)日：2018-09-20

申请号：US15853249

申请日：2017-12-22

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/00

CPC classification number: A61B5/4839 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/157 ,  A61B5/6866 ,  A61M5/1415 ,  A61M5/1452 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/201

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.