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    Fluorescence-Detected Mid-Infrared Photothermal Microscopy
    1.
    发明公开
    Fluorescence-Detected Mid-Infrared Photothermal Microscopy 审中-公开

    公开(公告)号：US20240328949A1

    公开(公告)日：2024-10-03

    申请号：US18286320

    申请日：2022-04-12

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Garth Jason Simpson ,  Aleksandr Razumtcev ,  Minghe Li

    IPC: G01N21/64 ,  G01N21/17 ,  G01N21/35 ,  G01N21/63

    CPC classification number: G01N21/6458 ,  G01N21/35 ,  G01N21/636 ,  G01N2021/1731 ,  G01N2021/3595 ,  G01N2021/6439 ,  G01N2201/06113

    Abstract: A method of selectively photothermally heating a sample in a fluorescence-detected mid-infrared photothermal microscopy is disclosed which includes energizing a sample with one or more modulated infrared (IR) beams sourced by a multichannel laser array, concurrently continuously illuminating the sample with a probe beam, thereby generating a fluorescence response signal, capturing the fluorescence response signal, processing the captured modulated fluorescence response signal into two IR absorption spectra corresponding to chemical properties of two components in the sample by scanning over each channel of the multichannel laser array, generating a binary mask associated with the two spectra, establishing a cost function based on the generated binary mask, optimizing the cost function by optimizing the binary mask, and selectively energizing channels of the multichannel laser array based on the optimized binary mask thereby maximizing discrimination between the two components.

    Axially-offset differential interference contrast correlation spectroscopy
    4.
    发明授权
    Axially-offset differential interference contrast correlation spectroscopy 有权

    公开(公告)号：US11656164B2

    公开(公告)日：2023-05-23

    申请号：US17329017

    申请日：2021-05-24

    Applicant: Purdue Research Foundation

    Inventor： Garth Jason Simpson ,  Chen Li ,  Changqin Ding

    IPC: G01N15/02 ,  G01J3/02 ,  G01J3/457

    CPC classification number: G01N15/0211 ,  G01J3/0224 ,  G01J3/457 ,  G01N15/0227

    Abstract: A method of obtaining a measurement signal representative of the particle size distributions in nanocrystal suspensions that includes a step of providing a first light beam along a first axis to a first micro-retarder array to generate polarization wavefront shaped light. The shaped light is applied to an objective configured to focus two orthogonally polarized components of the polarization wavefront shaped light to produce first and second axially offset foci along the first axis. A sample having particles in suspension is disposed in one foci to produce a measurement optical signal having phase and intensity values corresponding to at least some of the particles in suspension. The method also includes determining intensity and quantitative phase information as a function of time based on the optical signals.

    Systems and methods for imaging a sample
    5.
    发明授权
    Systems and methods for imaging a sample 有权

    公开(公告)号：US11635610B2

    公开(公告)日：2023-04-25

    申请号：US17322903

    申请日：2021-05-18

    Applicant: Purdue Research Foundation

    Inventor： Garth Jason Simpson ,  James Ulcickas ,  Fengyuan Deng ,  Changqin Ding

    IPC: G02B21/36 ,  G01N21/21 ,  G06T5/00 ,  G02B21/26 ,  G02B21/06

    Abstract: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.

    LINEAR FITTING OF MULTI-THRESHOLD COUNTING DATA
    6.
    发明申请
    LINEAR FITTING OF MULTI-THRESHOLD COUNTING DATA 审中-公开

    公开(公告)号：US20200174142A1

    公开(公告)日：2020-06-04

    申请号：US16209938

    申请日：2018-12-04

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Garth Jason Simpson ,  Ryan Douglas Muir ,  Nicholas Roman Pogranichniy

    IPC: G01T1/24 ,  G01T1/36 ,  G01T1/17

    Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.0 keV data can be analytically separated to recover the monochromatic images through simple linear fitting.

    HIGH FRAME-RATE MULTICHANNEL BEAM-SCANNING MICROSCOPY
    7.
    发明申请
    HIGH FRAME-RATE MULTICHANNEL BEAM-SCANNING MICROSCOPY 有权
    高帧率多通道光束扫描显微镜

    公开(公告)号：US20160004060A1

    公开(公告)日：2016-01-07

    申请号：US14735959

    申请日：2015-06-10

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Garth Jason Simpson ,  Charles Addison Bouman ,  Ryan Douglas Muir ,  Shane Sullivan ,  Justin Allen Newman ,  Mark Carlsen

    IPC: G02B21/00 ,  G06T5/00 ,  G02B26/10

    CPC classification number: G02B21/0084 ,  G02B21/0048 ,  G02B21/0076 ,  G02B26/101

    Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.

    Abstract translation: 描述了用于在多个同时数据采集通道上实现高达kHz帧频光学成像的波束扫描光学设计。 在一个实施例中，两个快速扫描谐振反射镜将光束引导通过视场的迂回轨迹，轨迹重复时间由反射镜周期的最小公倍数给出。 将原始时域数据划分为与基于模型的图像重建（MBIR）相结合的子轨迹。3D绘图算法允许比Lissajous轨迹的重复时间高得多的有效帧速率。 因为子轨迹和全轨迹成像是分析相同数据的不同方法，同时获取具有较低分辨率的高帧率图像和高分辨率的低帧率图像。

    METHOD OF MEASURING DIFFUSION IN A MEDIUM
    10.
    发明申请
    METHOD OF MEASURING DIFFUSION IN A MEDIUM 有权

    公开(公告)号：US20220099574A1

    公开(公告)日：2022-03-31

    申请号：US17487981

    申请日：2021-09-28

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Garth Jason Simpson ,  Andreas C. Geiger

    IPC: G01N21/64 ,  G02B21/16 ,  G02B21/36

    Abstract: Methods for measuring diffusion in a medium. One method includes dissolving a fluorescent sample in a medium, imaging the fluorescent sample with a patterned illumination Fluorescence Recovery After Photobleaching (FRAP) technique, and analyzing a set of microscope images of the photobleached dissolved fluorescent sample with the patterned illumination using a Fourier Transform (FT) FRAP technique.

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