公开(公告)号：US08994947B2

公开(公告)日：2015-03-31

申请号：US13752320

申请日：2013-01-28

Applicant: Pranalytica, Inc.

Inventor： C. Kumar Patel ,  L. Ravi Narasimhan

IPC: G01N21/59 ,  G01N21/39

CPC classification number: G01N21/39 ,  G01N21/1702 ,  G01N21/59 ,  G01N2021/1704 ,  G01N2201/022 ,  G01N2201/06113

Abstract: A method for detecting component concentrations in human gas emissions such as breath and gas emitted from skin. A gas sample containing a specified component is collected into a gas cell using a pump and a series of valves to draw the gas sample into the cell and control the gas pressure within the cell. A tunable optical radiation beam is passed through the gas cell and the amount of energy absorbed by the specified component may be measured indirectly by taking the difference between the incident and emerging beam energy or directly by optoacoustic methods. Concentrations of the specified component as small as 0.1 ppB may be determined. Additionally, the tunable optical radiation beam may be multiplexed for use with a plurality of systems utilizing the beam for medical purposes.

Abstract translation: 一种检测人体气体排放物中成分浓度的方法，如从皮肤发出的呼吸和气体。 使用泵和一系列阀将含有特定组分的气体样品收集到气室中，以将气体样品吸入电池并控制电池内的气体压力。 可调谐的光辐射束通过气室，并且可以通过考虑入射光束能量和出射光束能量之间的差异或直接通过光声法间接地测量由特定部件吸收的能量的量。 可以确定小于0.1ppB的指定组分的浓度。 此外，可调谐光辐射束可以被复用以与利用用于医疗目的的光束的多个系统一起使用。

公开(公告)号：US09285310B2

公开(公告)日：2016-03-15

申请号：US14630492

申请日：2015-02-24

Applicant: Pranalytica, Inc.

Inventor： C. Kumar Patel ,  L. Ravi Narasimhan

IPC: G01N21/39 ,  G01N21/17 ,  G01N21/59

CPC classification number: G01N21/39 ,  G01N21/1702 ,  G01N21/59 ,  G01N2021/1704 ,  G01N2201/022 ,  G01N2201/06113

Abstract: A system for collecting gas samples emitted from skin and detecting concentrations of specified components therein. The system includes a collection chamber housing defining an interior space, the collection chamber housing having a gas inlet, a gas outlet, and an opening. The opening is configured for enclosing a skin portion from which to receive an emitted gas sample and sealing the interior space against the skin portion. An inert gas source is connected to the gas inlet, which is capable of allowing inert gas from the inert gas source to flow into the interior space. A gas cell is connected to the gas outlet, which is capable of allowing the inert gas and the gas sample to flow from the interior space into the gas cell. As a laser travels through the gas cell, power and optoacoustic signals are measured and used to determine a concentration of the specified component.

Abstract translation: 用于收集从皮肤发出的气体样品并检测其中特定组分的浓度的系统。 该系统包括限定内部空间的收集室壳体，收集室壳体具有气体入口，气体出口和开口。 开口构造成用于封闭皮肤部分，从该部分接收发射的气体样品并将内部空间密封抵靠皮肤部分。 惰性气体源连接到气体入口，其能够允许来自惰性气体源的惰性气体流入内部空间。 气体单元连接到气体出口，其能够使惰性气体和气体样品从内部空间流入气室。 当激光穿过气室时，测量功率和光声信号，并用于确定特定部件的浓度。

公开(公告)号：US20150211990A1

公开(公告)日：2015-07-30

申请号：US14630492

申请日：2015-02-24

Applicant: Pranalytica, Inc.

Inventor： C. Kumar Patel ,  L. Ravi Narasimhan

IPC: G01N21/39 ,  G01N21/17 ,  G01N21/59

CPC classification number: G01N21/39 ,  G01N21/1702 ,  G01N21/59 ,  G01N2021/1704 ,  G01N2201/022 ,  G01N2201/06113

Abstract: A system for collecting gas samples emitted from skin and detecting concentrations of specified components therein. The system includes a collection chamber housing defining an interior space, the collection chamber housing having a gas inlet, a gas outlet, and an opening. The opening is configured for enclosing a skin portion from which to receive an emitted gas sample and sealing the interior space against the skin portion. An inert gas source is connected to the gas inlet, which is capable of allowing inert gas from the inert gas source to flow into the interior space. A gas cell is connected to the gas outlet, which is capable of allowing the inert gas and the gas sample to flow from the interior space into the gas cell. As a laser travels through the gas cell, power and optoacoustic signals are measured and used to determine a concentration of the specified component.

Abstract translation: 用于收集从皮肤发出的气体样品并检测其中特定组分的浓度的系统。 该系统包括限定内部空间的收集室壳体，收集室壳体具有气体入口，气体出口和开口。 开口构造成用于封闭皮肤部分，从该部分接收发射的气体样品并将内部空间密封抵靠皮肤部分。 惰性气体源连接到气体入口，其能够允许来自惰性气体源的惰性气体流入内部空间。 气体单元连接到气体出口，其能够允许惰性气体和气体样品从内部空间流入气体单元。 当激光穿过气室时，测量功率和光声信号，并用于确定特定部件的浓度。