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    Methods and apparatuses for determining the intact mass of large molecules from mass spectrographic data
    3.
    发明授权
    Methods and apparatuses for determining the intact mass of large molecules from mass spectrographic data 有权

    公开(公告)号：US10319573B2

    公开(公告)日：2019-06-11

    申请号：US15881698

    申请日：2018-01-26

    Applicant: Protein Metrics Inc.

    Inventor： Marshall Bern

    IPC: H01J49/26 ,  H01J49/00 ,  H01J49/16

    Abstract: Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. The method involves using a measured spectrum of data from a sample taken with a mass spectrometer, deconvoluting the measured spectrum of data by applying parsimony weighting to minimize the number of charge states based on one or more of: the number of intense peaks in the mass spectrum; the number of harmonic relationships (e.g., masses in small integer ratios); and the number of off-by-one relationships (e.g., m/z bins with high probability for two adjacent charges). Thus, the underlying m/z spectrum may be inferred from the family of plausible deconvoluted spectra determined by applying parsimony and the inferred m/z spectrum may be used to identify and/or characterize the sample.

    Methods and apparatuses for determining the intact mass of large molecules from mass spectrographic data
    4.
    发明授权
    Methods and apparatuses for determining the intact mass of large molecules from mass spectrographic data 有权

    公开(公告)号：US11127575B2

    公开(公告)日：2021-09-21

    申请号：US16883983

    申请日：2020-05-26

    Applicant: Protein Metrics Inc.

    Inventor： Marshall Bern

    IPC: H01J49/00 ,  H01J49/16

    Abstract: Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. The method involves using a measured spectrum of data from a sample taken with a mass spectrometer, deconvoluting the measured spectrum of data by applying parsimony weighting to minimize the number of charge states based on one or more of: the number of intense peaks in the mass spectrum; the number of harmonic relationships (e.g., masses in small integer ratios); and the number of off-by-one relationships (e.g., m/z bins with high probability for two adjacent charges). Thus, the underlying m/z spectrum may be inferred from the family of plausible deconvoluted spectra determined by applying parsimony and the inferred m/z spectrum may be used to identify and/or characterize the sample.

    Intact mass reconstruction from peptide level data and facilitated comparison with experimental intact observation
    6.
    发明授权
    Intact mass reconstruction from peptide level data and facilitated comparison with experimental intact observation 有权

    公开(公告)号：US11346844B2

    公开(公告)日：2022-05-31

    申请号：US16859758

    申请日：2020-04-27

    Applicant: Protein Metrics Inc.

    Inventor： Andrew Nichols ,  Marshall Bern ,  Yong Joo Kil ,  Eric Carlson

    IPC: G01N33/68 ,  H01J49/00

    Abstract: Methods and apparatuses for the identification and/or characterization of properties of a macromolecule based on mass spectrometry data. Specifically, described herein are methods and apparatuses for converting peptide-level data into a pseudo-intact mass spectra. Also described herein are methods and apparatuses for converting peptide-level data into a pseudo-electropherogram. The methods may be well suited for analyzing proteins and protein complexes, including estimating properties of post-translational modifications of the proteins and protein complexes. Methods may include generating a theoretical graph or spectrum based on peptide-level mass spectrometry data. In some embodiments, the theoretical graph may be a theoretical intact mass spectrum or a theoretical charge distribution spectrum.

    Methods and apparatuses for determining the intact mass of large molecules from mass spectrographic data
    7.
    发明授权
    Methods and apparatuses for determining the intact mass of large molecules from mass spectrographic data 有权

    公开(公告)号：US10665439B2

    公开(公告)日：2020-05-26

    申请号：US16438279

    申请日：2019-06-11

    Applicant: Protein Metrics Inc.

    Inventor： Marshall Bern

    IPC: H01J49/16 ,  H01J49/00

    Abstract: Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. The method involves using a measured spectrum of data from a sample taken with a mass spectrometer, deconvoluting the measured spectrum of data by applying parsimony weighting to minimize the number of charge states based on one or more of: the number of intense peaks in the mass spectrum; the number of harmonic relationships (e.g., masses in small integer ratios); and the number of off-by-one relationships (e.g., m/z bins with high probability for two adjacent charges). Thus, the underlying m/z spectrum may be inferred from the family of plausible deconvoluted spectra determined by applying parsimony and the inferred m/z spectrum may be used to identify and/or characterize the sample.

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