公开(公告)号：US20220396550A1

公开(公告)日：2022-12-15

申请号：US17826061

申请日：2022-05-26

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Monika Yadav ,  Andrew Mesecar

IPC: C07D207/26 ,  C07D227/087

Abstract: Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

公开(公告)号：US20220389030A1

公开(公告)日：2022-12-08

申请号：US17567737

申请日：2022-01-03

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Andrew Mesecar ,  Margherita Brindisi ,  Emilio Leal Cardenas

IPC: C07D513/04 ,  C07C233/78 ,  C07D307/22 ,  C07D309/14 ,  C07D519/00

Abstract: Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.

公开(公告)号：US11214579B2

公开(公告)日：2022-01-04

申请号：US16847398

申请日：2018-10-12

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Andrew Mesecar ,  Margherita Brindisi ,  Emilio Leal Cardenas

IPC: A61K31/554 ,  A61P25/28 ,  C07D513/06 ,  C07D513/04 ,  C07C233/78 ,  C07D307/22 ,  C07D309/14 ,  C07D519/00

Abstract: Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.

公开(公告)号：US20210196684A1

公开(公告)日：2021-07-01

申请号：US17199559

申请日：2021-03-12

Applicant: Purdue Research Foundation

Inventor： Antonella Pepe ,  Andrew Mesecar

IPC: A61K31/4162 ,  A61K45/06 ,  C07D491/052

Abstract: The present invention generally relates to 6-amino-2,4-dihydropyrano[2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.

公开(公告)号：US20200299308A1

公开(公告)日：2020-09-24

申请号：US16847398

申请日：2018-10-12

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Andrew Mesecar ,  Margherita Brindisi ,  Emilio Leal Cardenas

IPC: C07D513/04 ,  C07C233/78 ,  C07D307/22 ,  C07D309/14 ,  C07D519/00

Abstract: Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.

公开(公告)号：US12043631B2

公开(公告)日：2024-07-23

申请号：US17567737

申请日：2022-01-03

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Andrew Mesecar ,  Margherita Brindisi ,  Emilio Leal Cardenas

IPC: C07D307/22 ,  A61K31/166 ,  A61K31/341 ,  A61K31/351 ,  A61P25/28 ,  C07C233/78 ,  C07D309/14 ,  C07D513/04 ,  C07D513/06 ,  C07D519/00

CPC classification number: C07D513/04 ,  C07C233/78 ,  C07D307/22 ,  C07D309/14 ,  C07D519/00

Abstract: Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.

公开(公告)号：US20240043417A1

公开(公告)日：2024-02-08

申请号：US18255339

申请日：2021-11-30

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Hiroaki Mitsuya ,  Andrew Mesecar

IPC: C07D417/14 ,  C07D403/12 ,  C07D413/14 ,  C07D401/12

CPC classification number: C07D417/14 ,  C07D403/12 ,  C07D413/14 ,  C07D401/12

Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID) and methods of using them to treat a severe acute respiratory syndrome.

公开(公告)号：US20230192671A1

公开(公告)日：2023-06-22

申请号：US17998909

申请日：2021-03-15

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Hiroaki Mitsuya ,  Andrew Mesecar

IPC: C07D405/12 ,  C07D213/56 ,  C07D401/12 ,  C07D413/12 ,  C07D493/04 ,  C07D493/08 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D493/06 ,  C07D519/00 ,  C07D498/04

CPC classification number: C07D405/12 ,  C07D213/56 ,  C07D401/12 ,  C07D413/12 ,  C07D493/04 ,  C07D493/08 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D493/06 ,  C07D519/00 ,  C07D498/04

Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

公开(公告)号：US11617738B2

公开(公告)日：2023-04-04

申请号：US17199559

申请日：2021-03-12

Applicant: Purdue Research Foundation

Inventor： Antonella Pepe ,  Andrew Mesecar

IPC: A61K31/4162 ,  A61K45/06 ,  C07D491/052

Abstract: The present invention generally relates to 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.

公开(公告)号：US20240124395A1

公开(公告)日：2024-04-18

申请号：US18492411

申请日：2023-10-23

Applicant: Purdue Research Foundation

Inventor： Arun K. Ghosh ,  Monika Yadav ,  Andrew Mesecar

IPC: C07D207/26 ,  C07D227/087

CPC classification number: C07D207/26 ,  C07D227/087

Abstract: Inhibitors of SARS-COV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.