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    Method and device for annihilation of methicillin-resistant Staphylococcus aureus
    1.
    发明授权
    Method and device for annihilation of methicillin-resistant Staphylococcus aureus 有权

    公开(公告)号：US11013933B2

    公开(公告)日：2021-05-25

    申请号：US16139127

    申请日：2018-09-24

    Applicant: Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Mohamed Seleem ,  Pu-Ting Dong ,  Jie Hui

    IPC: A61N5/06 ,  C12N13/00 ,  A61K31/546 ,  A61K31/7036 ,  A61K31/496 ,  A61K38/12 ,  A61K31/431 ,  A61N5/067

    Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) possesses array of strategies to evade antibiotics through mutational inactivation, hiding inside host immune cells or concealing inside the biofilm in a sessile form. We report a drug-free approach to eradicate MRSA through blue-light bleaching of staphyloxanthin (STX), an anti-oxidative carotenoid residing inside the cell membrane of S. aureus. The photobleaching process, uncovered through a transient absorption imaging study and quantitated by mass spectrometry, decomposes STX and sensitizes MRSA to reactive oxygen species attack. Consequently, photobleaching using low-level blue light exhibits high-level synergy when combined with low-concentration of hydrogen peroxide. Antimicrobial effectiveness of this synergistic therapy is validated in MRSA culture, MRSA-infected macrophage cells, biofilm, and a mouse wound infection model. Collectively, these findings highlight broad applications of STX photobleaching for MRSA-infected diseases.

    SYSTEMS AND METHODS FOR BOND-SELECTIVE TRANSIENT PHASE IMAGING
    2.
    发明申请
    SYSTEMS AND METHODS FOR BOND-SELECTIVE TRANSIENT PHASE IMAGING 审中-公开

    公开(公告)号：US20200348182A1

    公开(公告)日：2020-11-05

    申请号：US16865082

    申请日：2020-05-01

    Applicant: Trustees of Boston University ,  Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Delong Zhang ,  Lu Lan

    IPC: G01J5/08 ,  H01S3/094 ,  G02F1/125

    Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.

    Systems and methods for bond-selective transient phase imaging
    4.
    发明授权
    Systems and methods for bond-selective transient phase imaging 有权

    公开(公告)号：US11199453B2

    公开(公告)日：2021-12-14

    申请号：US17067345

    申请日：2020-10-09

    Applicant: Trustees of Boston University ,  Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Delong Zhang ,  Lu Lan

    IPC: G01J5/08 ,  G02F1/125 ,  H01S3/094 ,  G01J5/00

    Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.

    SYSTEMS AND METHODS FOR BOND-SELECTIVE TRANSIENT PHASE IMAGING
    5.
    发明申请
    SYSTEMS AND METHODS FOR BOND-SELECTIVE TRANSIENT PHASE IMAGING 有权

    公开(公告)号：US20210108968A1

    公开(公告)日：2021-04-15

    申请号：US17067345

    申请日：2020-10-09

    Applicant: Trustees of Boston University ,  Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Delong Zhang ,  Lu Lan

    IPC: G01J5/08 ,  G02F1/125 ,  H01S3/094

    Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.

    Methods for determining aggressiveness of a cancer and treatment thereof
    10.
    发明授权
    Methods for determining aggressiveness of a cancer and treatment thereof 有权
    用于确定癌症侵袭性的方法及其治疗

    公开(公告)号：US09164084B2

    公开(公告)日：2015-10-20

    申请号：US14371598

    申请日：2013-01-25

    Applicant: Purdue Research Foundation

    Inventor： Ji-Xin Cheng

    IPC: A61K31/18 ,  G01N33/50 ,  A61B5/00

    CPC classification number: G01N33/5091 ,  A61B5/0073 ,  A61B5/4842 ,  A61K31/18

    Abstract: The invention generally relates to methods for determining aggressiveness of a cancer and treatment thereof. Certain aspects of the invention provide methods that involve conducting an assay on a lipid droplet in order to detect an amount of a biomarker within the lipid droplet, and determining aggressiveness of a cancer based upon the amount of the biomarker within the lipid droplet. Other aspects of the invention provide methods for treating a cancer that involve administering an agent that blocks storage of cholesteryl ester in a lipid droplet.

    Abstract translation: 本发明一般涉及确定癌症侵袭性及其治疗方法。 本发明的某些方面提供了涉及对脂滴进行测定以检测脂滴内的生物标志物的量的方法，以及基于脂滴内的生物标志物的量确定癌症的侵袭性。 本发明的其它方面提供了治疗癌症的方法，所述方法涉及施用阻断胆脂酯在脂滴中的储存的试剂。

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