公开(公告)号：US11504357B2

公开(公告)日：2022-11-22

申请号：US16869268

申请日：2020-05-07

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64 ,  A61K31/426 ,  C07C323/52 ,  A61K51/04

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US11318121B2

公开(公告)日：2022-05-03

申请号：US17359314

申请日：2021-06-25

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Sumith A. Kularatne

IPC: A61K47/54 ,  A61K51/04 ,  A61K51/08 ,  A61K47/64 ,  A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K49/00 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20210077468A1

公开(公告)日：2021-03-18

申请号：US17086063

申请日：2020-10-30

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Sumith A. Kularatne

IPC: A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10828282B2

公开(公告)日：2020-11-10

申请号：US15990152

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/54 ,  A61K47/64 ,  A61K51/04 ,  A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K49/00 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20200261592A1

公开(公告)日：2020-08-20

申请号：US16869268

申请日：2020-05-07

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K51/08 ,  A61K51/04 ,  A61K47/54 ,  A61K49/00 ,  C07C323/52 ,  C07K5/08 ,  A61K31/475 ,  A61K31/426 ,  A61K31/4745 ,  C07D207/416

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US20190002861A1

公开(公告)日：2019-01-03

申请号：US15934974

申请日：2018-03-24

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: C12N9/48 ,  A61K49/00 ,  A61K31/454 ,  C12N9/96 ,  A61K51/04 ,  A61K47/54 ,  A61K31/475 ,  A61K31/4745 ,  A61K38/00

CPC classification number: C12N9/485 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K38/00 ,  A61K47/542 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0402 ,  A61K51/0497 ,  C12N9/96 ,  C12Y304/17021

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US09782497B2

公开(公告)日：2017-10-10

申请号：US14953928

申请日：2015-11-30

Applicant: Purdue Research Foundation

Inventor： Sumith A. Kularatne

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  G01N33/569 ,  G01N33/566 ,  G01N33/50 ,  G01N33/58 ,  G01N33/68 ,  C07D475/04 ,  G01N33/574 ,  G01N21/64

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US09233175B2

公开(公告)日：2016-01-12

申请号：US14135099

申请日：2013-12-19

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne ,  Lindsay E. Kelderhouse ,  Sakkarapalayam M. Mahalingam

IPC: A61K49/00 ,  G01N33/569 ,  G01N33/566 ,  G01N33/50

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods of imaging of inflammatory diseases using the compounds.

Abstract translation: 本公开涉及可用作近红外荧光探针的化合物，其中所述化合物包括i）与靶受体蛋白结合的蝶啶配体，ii）染料分子，和iii）包含氨基酸的连接分子 或其衍生物。 本公开进一步描述了使用该化合物成像炎性疾病的方法。

公开(公告)号：US11369590B2

公开(公告)日：2022-06-28

申请号：US17359277

申请日：2021-06-25

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Sumith A. Kularatne

IPC: A61K31/426 ,  C07C323/52 ,  C07D207/416 ,  A61K47/54 ,  A61K49/00 ,  A61K51/04 ,  C07K5/08 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08 ,  A61K47/64

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US11298341B2

公开(公告)日：2022-04-12

申请号：US16507713

申请日：2019-07-10

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K31/426 ,  A61K47/54 ,  A61K49/00 ,  C07K5/08 ,  A61K51/08 ,  A61K47/64 ,  C07C323/52 ,  C07D207/416 ,  A61K51/04 ,  A61K31/4745 ,  A61K31/475

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.