公开(公告)号：US12220454B2

公开(公告)日：2025-02-11

申请号：US17199972

申请日：2021-03-12

Applicant: Purdue Research Foundation

Inventor： Suresh Kumar Mittal

IPC: A61K39/145 ,  A61P31/16 ,  A61P37/04 ,  A61K39/00

Abstract: Disclosed herein a unique cell line system to generate a novel bovine adenovirus vector that provides more gene insertion capabilities and better immunogenicity for inserted antigens. The unique cell line is used for generating and growing of the new adenovirus vectors for gene delivery or recombinant vaccine production.

公开(公告)号：US10968464B2

公开(公告)日：2021-04-06

申请号：US16359973

申请日：2019-03-20

Applicant: Purdue Research Foundation

Inventor： Suresh Kumar Mittal

IPC: C12N15/00 ,  C12N5/00 ,  C12N15/86 ,  C07K14/09 ,  C07K14/11

Abstract: Disclosed herein a unique cell line system to generate a novel bovine adenovirus vector that provides more gene insertion capabilities and better immunogenicity for inserted antigens. The unique cell line is used for generating and growing of the new adenovirus vectors for gene delivery or recombinant vaccine production.

公开(公告)号：US20240366741A1

公开(公告)日：2024-11-07

申请号：US18550036

申请日：2022-03-08

Applicant: Purdue Research Foundation ,  HOUSTON METHODIST RESEARCH INSTITUTE

Inventor： Suresh Kumar Mittal ,  Chinnaswamy Jagannath

IPC: A61K39/04 ,  A61K39/00 ,  A61P31/06 ,  C12N15/86

Abstract: The present invention discloses a recombinant adenovirus vector of a replication-defective human adenovirus (HAdv85C5) or a bovine adenovirus (BAdv85C5) comprising a recombinant adenovirus vector having a heterologous DNA segment encoding mycobacterial Ag85B-p25 epitope (SEQ ID NO: 1), mycobacterial Ag85B-p25 epitope fusion of autophagy-inducing peptide-C5 (SEQ ID NO: 2), or a substantially homologous functional fragment thereof. The vector, having a heterologous DNA segment of SEQ ID NO: 3, SEQ ID NO: 4, or a substantially homologous functional fragment thereof, is an effective vaccine for therapeutically or prophylactically immunizing a subject for protection of infections by various microorganisms, especially Mycobacterium tuberculosis (Mtb), which causes the widespread tuberculosis. Methods of uses and pharmaceutical composition matters are within the scope of this disclosure.

公开(公告)号：US20250057935A1

公开(公告)日：2025-02-20

申请号：US18749120

申请日：2024-06-20

Applicant: Purdue Research Foundation

Inventor： Suresh Kumar Mittal

IPC: A61K39/145 ,  A61K39/00 ,  A61P31/16 ,  A61P37/04

Abstract: Disclosed herein a unique cell line system to generate a novel bovine adenovirus vector that provides more gene insertion capabilities and better immunogenicity for inserted antigens. The unique cell line is used for generating and growing of the new adenovirus vectors for gene delivery or recombinant vaccine production.

公开(公告)号：US20220288188A1

公开(公告)日：2022-09-15

申请号：US17199972

申请日：2021-03-12

Applicant: Purdue Research Foundation

Inventor： Suresh Kumar Mittal

IPC: A61K39/145 ,  A61P37/04 ,  A61P31/16

Abstract: Disclosed herein a unique cell line system to generate a novel bovine adenovirus vector that provides more gene insertion capabilities and better immunogenicity for inserted antigens. The unique cell line is used for generating and growing of the new adenovirus vectors for gene delivery or recombinant vaccine production.

公开(公告)号：US20190292562A1

公开(公告)日：2019-09-26

申请号：US16359973

申请日：2019-03-20

Applicant: Purdue Research Foundation

Inventor： Suresh Kumar Mittal

IPC: C12N15/86 ,  C07K14/11 ,  C07K14/09

Abstract: Disclosed herein a unique cell line system to generate a novel bovine adenovirus vector that provides more gene insertion capabilities and better immunogenicity for inserted antigens. The unique cell line is used for generating and growing of the new adenovirus vectors for gene delivery or recombinant vaccine production.