公开(公告)号：US20170349903A1

公开(公告)日：2017-12-07

申请号：US15614147

申请日：2017-06-05

Applicant: Purdue Research Foundation

Inventor： Wanqing Liu ,  Yoon Yeo

IPC: C12N15/113 ,  A61K31/7088 ,  A61K31/713

CPC classification number: C12N15/1137 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/48123 ,  A61K47/48192 ,  A61K47/554 ,  A61K47/58 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32 ,  C12N2320/34 ,  C12Y301/01003

Abstract: The invention provides siRNA compositions that specifically downregulates expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD).

公开(公告)号：US11028393B2

公开(公告)日：2021-06-08

申请号：US16735034

申请日：2020-01-06

Applicant: Purdue Research Foundation

Inventor： Wanqing Liu ,  Yoon Yeo

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/713 ,  A61K31/7088 ,  A61K47/59 ,  A61K47/58 ,  A61K47/54 ,  A61K47/69

Abstract: The invention provides siRNA compositions that specifically downregulates expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD).

公开(公告)号：US20180327751A1

公开(公告)日：2018-11-15

申请号：US16026609

申请日：2018-07-03

Applicant: Purdue Research Foundation

Inventor： Wanqing Liu ,  Yoon Yeo

IPC: C12N15/113 ,  A61K31/7088 ,  A61K31/713

Abstract: The invention provides siRNA compositions that specifically downregulates expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD).

公开(公告)号：US20200270615A1

公开(公告)日：2020-08-27

申请号：US16735034

申请日：2020-01-06

Applicant: Purdue Research Foundation

Inventor： Wanqing Liu ,  Yoon Yeo

IPC: C12N15/113 ,  A61K31/713 ,  A61K31/7088 ,  A61K47/59 ,  A61K47/58 ,  A61K47/54 ,  A61K47/69

Abstract: The invention provides siRNA compositions that specifically downregulates expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD).

公开(公告)号：US10526605B2

公开(公告)日：2020-01-07

申请号：US16026609

申请日：2018-07-03

Applicant: Purdue Research Foundation

Inventor： Wanqing Liu ,  Yoon Yeo

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/713 ,  A61K31/7088 ,  A61K47/58 ,  A61K47/54 ,  A61K47/59 ,  A61K47/69

Abstract: The invention provides siRNA compositions that specifically downregulates expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD).

公开(公告)号：US10036024B2

公开(公告)日：2018-07-31

申请号：US15614147

申请日：2017-06-05

Applicant: Purdue Research Foundation

Inventor： Wanqing Liu ,  Yoon Yeo

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/713 ,  A61K31/7088 ,  A61K47/48

CPC classification number: C12N15/1137 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/554 ,  A61K47/58 ,  A61K47/59 ,  A61K47/6923 ,  A61K47/6933 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32 ,  C12N2320/34 ,  C12Y301/01003

Abstract: The invention provides siRNA compositions that specifically downregulates expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD).