公开(公告)号：US09279813B2

公开(公告)日：2016-03-08

申请号：US14187844

申请日：2014-02-24

Applicant: Purdue Research Foundation

Inventor： Philip Stewart Low ,  Wei He ,  Sumith A. Kularatne

IPC: G01N33/574 ,  G01N33/58 ,  G01N33/50 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N33/582 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/5091 ,  G01N33/574 ,  G01N33/57434 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/149 ,  G01N2458/00

Abstract: The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.

Abstract translation: 本发明涉及诊断由致病细胞介导的疾病状态的方法。 该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，以及 使用流式细胞术检测表达配体受体的致病细胞。