公开(公告)号：US12110519B2

公开(公告)日：2024-10-08

申请号：US17283980

申请日：2019-10-02

Applicant: Purdue Research Foundation

Inventor： Zoltan K. Nagy ,  Joseph A. Oliva ,  Kanjakha Pal

IPC: C12N9/36 ,  A61K38/47 ,  C07K1/02 ,  C12N9/98

CPC classification number: C12N9/2462 ,  A61K38/47 ,  C07K1/026 ,  C12N9/98 ,  C12Y302/01017

Abstract: The present disclosure relates to a novel spherical agglomeration method for proteins, and protein particles made by the spherical agglomeration method. By using continuous oscillatory baffled crystallizer, the method of the present disclosure is capable of maintain the biologically activities and providing protein particles with an average particle size between 1-500 μm.

公开(公告)号：US12076444B2

公开(公告)日：2024-09-03

申请号：US18152394

申请日：2023-01-10

Applicant: Purdue Research Foundation

Inventor： Arun V. Giridhar ,  Michael Harris ,  Gintaras V. Reklaitis ,  Lynne S. Taylor ,  Zoltan K. Nagy ,  Elcin Icten ,  Frederick Fiesser ,  Laura Hirshfield

IPC: A61K9/70 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/415 ,  A61K31/635 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K47/38 ,  B01J4/00 ,  B01J4/02

CPC classification number: A61K9/7007 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/415 ,  A61K31/635 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K47/38 ,  B01J4/002 ,  B01J4/008 ,  B01J4/02 ,  B01J2204/005 ,  B01J2204/007

Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

公开(公告)号：US20180228737A1

公开(公告)日：2018-08-16

申请号：US15751771

申请日：2016-08-09

Applicant: Purdue Research Foundation

Inventor： Arun V. Giridhar ,  Michael Harris ,  Gintaras V. Raklaitis ,  Lynne S. Taylor ,  Zoltan K. Nagy ,  Elcin Icten ,  Frederick Fiesser ,  Laura Hirshfield

IPC: A61K9/70 ,  B01J4/00 ,  B01J4/02 ,  A61K31/192 ,  A61K47/34 ,  A61K47/38 ,  A61K31/635 ,  A61K31/167 ,  A61K31/196 ,  A61K47/14

CPC classification number: A61K9/7007 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/415 ,  A61K31/635 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K47/38 ,  B01J4/002 ,  B01J4/008 ,  B01J4/02 ,  B01J2204/005 ,  B01J2204/007

Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

公开(公告)号：US11547675B2

公开(公告)日：2023-01-10

申请号：US15751771

申请日：2016-08-09

Applicant: Purdue Research Foundation

Inventor： Arun V. Giridhar ,  Michael Harris ,  Gintaras V. Reklaitis ,  Lynne S. Taylor ,  Zoltan K. Nagy ,  Elcin Icten ,  Frederick Fiesser ,  Laura Hirshfield

IPC: A61K9/70 ,  A61K47/10 ,  A61K31/415 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/635 ,  A61K47/14 ,  A61K47/34 ,  A61K47/38 ,  B01J4/00 ,  B01J4/02

Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

公开(公告)号：US20210380959A1

公开(公告)日：2021-12-09

申请号：US17283980

申请日：2019-10-02

Applicant: Purdue Research Foundation

Inventor： Zoltan K. Nagy ,  Joseph A. Oliva ,  Kanjakha Pal

IPC: C12N9/36 ,  C07K1/02 ,  A61K38/47 ,  C12N9/98

Abstract: The present disclosure relates to a novel spherical agglomeration method for proteins, and protein particles made by the spherical agglomeration method. By using continuous oscillatory baffled crystallizer, the method of the present disclosure is capable of maintain the biologically activities and providing protein particles with an average particle size between 1-500 μm.