公开(公告)号：US10696714B2

公开(公告)日：2020-06-30

申请号：US16422102

申请日：2019-05-24

Applicant: Puridify Ltd.

Inventor： Daniel Gilbert Bracewell ,  Robert Stevens ,  Oliver Hardick

IPC: C07K1/16 ,  B01D15/36 ,  B01J20/28 ,  B01J20/30 ,  C07K1/18 ,  C07K1/22 ,  B01J20/24 ,  B82Y30/00 ,  B01D15/18 ,  B01D15/38 ,  B01J20/285

Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.

公开(公告)号：US12070735B2

公开(公告)日：2024-08-27

申请号：US17078435

申请日：2020-10-23

Applicant: Puridify Ltd.

Inventor： Oliver Hardick ,  Daniel Gilbert Bracewell ,  Stewart Dods

IPC: B01D39/14 ,  B01D15/32 ,  B01D15/36 ,  B01D15/38 ,  B01D39/16 ,  B01J20/24 ,  B01J20/26 ,  B01J20/28 ,  B01J20/285 ,  B01J20/287 ,  B01J20/288 ,  B01J20/30 ,  B01J39/05 ,  B01J39/19 ,  B01J39/26 ,  B01J41/07 ,  B01J41/13 ,  B01J41/20 ,  B29C65/00 ,  B29C65/02 ,  B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B37/06 ,  B32B37/10 ,  B32B37/18 ,  C07K1/16 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22 ,  B29K601/00 ,  B29K627/18 ,  B29L9/00 ,  C12M1/12

CPC classification number: B01J20/265 ,  B01D15/327 ,  B01D15/361 ,  B01D15/362 ,  B01D15/363 ,  B01D15/38 ,  B01D15/3804 ,  B01D15/3809 ,  B01D15/3819 ,  B01D39/14 ,  B01D39/16 ,  B01D39/1623 ,  B01J20/24 ,  B01J20/28007 ,  B01J20/28033 ,  B01J20/28038 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/285 ,  B01J20/287 ,  B01J20/288 ,  B01J20/3007 ,  B01J20/3085 ,  B01J39/05 ,  B01J39/19 ,  B01J39/26 ,  B01J41/07 ,  B01J41/13 ,  B01J41/20 ,  B29C65/02 ,  B29C66/45 ,  B29C66/712 ,  B29C66/7294 ,  B32B5/022 ,  B32B27/08 ,  B32B27/12 ,  B32B27/322 ,  B32B37/06 ,  B32B37/10 ,  B32B37/182 ,  C07K1/165 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22 ,  B01J2220/54 ,  B29K2601/12 ,  B29K2627/18 ,  B29K2713/00 ,  B29L2009/00 ,  B32B2262/04 ,  B32B2317/18 ,  B32B2327/18 ,  C07K1/16 ,  C12M25/14

Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.

公开(公告)号：US10344051B2

公开(公告)日：2019-07-09

申请号：US15714781

申请日：2017-09-25

Applicant: Puridify Ltd.

Inventor： Daniel Gilbert Bracewell ,  Robert Stevens ,  Oliver Hardick

IPC: C07K1/16 ,  B01D15/36 ,  B01J20/28 ,  B01J20/285 ,  B01J20/30 ,  C07K1/18 ,  C07K1/22 ,  B01D15/18 ,  B01D15/38 ,  B01J20/24 ,  B82Y30/00

Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibers which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.

公开(公告)号：US20220268745A1

公开(公告)日：2022-08-25

申请号：US17737163

申请日：2022-05-05

Applicant: Puridify Ltd.

Inventor： Michael Williams ,  Iwan Roberts ,  Oliver Hardick ,  Matthew Townsend ,  Christopher Morris ,  Shameer Subratty

IPC: G01N30/38 ,  G01N30/60 ,  G01N30/84

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

公开(公告)号：US20210162370A1

公开(公告)日：2021-06-03

申请号：US17078435

申请日：2020-10-23

Applicant: Puridify Ltd.

Inventor： Oliver Hardick ,  Daniel Gilbert Bracewell ,  Stewart Dods

IPC: B01J20/26 ,  B01D15/38 ,  C07K1/18 ,  B01J20/285 ,  B01J20/24 ,  B01J20/30 ,  B01D15/36 ,  B01J20/28 ,  B01D15/32 ,  B01J39/05 ,  B01J41/13 ,  B01J41/07 ,  B01J39/19 ,  B01D39/14 ,  B01D39/16 ,  B01J20/287 ,  B01J20/288 ,  B01J39/26 ,  B01J41/20 ,  B29C65/02 ,  B29C65/00 ,  B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B37/06 ,  B32B37/10 ,  B32B37/18 ,  C07K1/16 ,  C07K1/20 ,  C07K1/22

Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.

公开(公告)号：US20180094022A1

公开(公告)日：2018-04-05

申请号：US15714781

申请日：2017-09-25

Applicant: Puridify Ltd.

Inventor： Daniel Gilbert Bracewell ,  Robert Stevens ,  Oliver Hardick

IPC: C07K1/16 ,  B01J20/28 ,  B01J20/285 ,  B01J20/30 ,  C07K1/18 ,  B01D15/36 ,  B01D15/18 ,  B01D15/38 ,  B01J20/24 ,  B82Y30/00 ,  C07K1/22

CPC classification number: C07K1/16 ,  B01D15/1821 ,  B01D15/361 ,  B01D15/3804 ,  B01J20/24 ,  B01J20/28007 ,  B01J20/28038 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/285 ,  B01J20/3007 ,  B82Y30/00 ,  C07K1/18 ,  C07K1/22

Abstract: The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.

公开(公告)号：US20160288089A1

公开(公告)日：2016-10-06

申请号：US15091158

申请日：2016-04-05

Applicant: Puridify Ltd.

Inventor： Oliver Hardick ,  Daniel Gilbert Bracewell ,  Stewart Dods

IPC: B01J20/26 ,  C07K1/22 ,  C07K1/20 ,  C07K1/16 ,  B01J20/28 ,  B01J20/287 ,  B01J20/288 ,  B01J39/18 ,  B01J39/04 ,  B01J39/26 ,  B01J41/04 ,  B01J41/12 ,  B01J41/20 ,  B01J20/30 ,  B01D15/36 ,  B01D15/38 ,  B29C65/02 ,  B29C65/00 ,  B32B37/06 ,  B32B5/02 ,  B32B27/32 ,  B32B27/08 ,  B32B27/12 ,  B32B37/10 ,  B32B37/18 ,  C07K1/18

CPC classification number: B01J20/265 ,  B01D15/327 ,  B01D15/361 ,  B01D15/362 ,  B01D15/363 ,  B01D15/38 ,  B01D15/3804 ,  B01D15/3809 ,  B01D15/3819 ,  B01J20/24 ,  B01J20/28007 ,  B01J20/28033 ,  B01J20/28038 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/285 ,  B01J20/287 ,  B01J20/288 ,  B01J20/3007 ,  B01J20/3085 ,  B01J39/05 ,  B01J39/19 ,  B01J39/26 ,  B01J41/07 ,  B01J41/13 ,  B01J41/20 ,  B01J2220/54 ,  B29C65/02 ,  B29C66/45 ,  B29C66/712 ,  B29C66/7294 ,  B29K2601/12 ,  B29K2627/18 ,  B29K2713/00 ,  B29L2009/00 ,  B32B5/022 ,  B32B27/08 ,  B32B27/12 ,  B32B27/322 ,  B32B37/06 ,  B32B37/10 ,  B32B37/182 ,  B32B2262/04 ,  B32B2317/18 ,  B32B2327/18 ,  C07K1/16 ,  C07K1/165 ,  C07K1/18 ,  C07K1/20 ,  C07K1/22

Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.

Abstract translation: 本发明提供了一种制备官能化聚合物色谱介质的方法，该方法包括（I）提供两个或更多个层叠在另一个上的非织造片材，每个所述片材同时包含一种或多种聚合物纳米纤维（II） 加热和压制叠片以熔化相邻片材的纳米纤维之间的接触点，和（III）使被加压和加热的产物与将作为色谱介质的步骤（II）的产物起作用的试剂接触。

公开(公告)号：US20240210365A1

公开(公告)日：2024-06-27

申请号：US18408693

申请日：2024-01-10

Applicant: Puridify Ltd.

Inventor： Michael Williams ,  Iwan Roberts ,  Oliver Hardick ,  Matthew Townsend ,  Christopher Morris ,  Shameer Subratty

IPC: G01N30/38 ,  G01N30/60

CPC classification number: G01N30/38 ,  G01N30/6017 ,  G01N2030/386

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

公开(公告)号：US11913918B2

公开(公告)日：2024-02-27

申请号：US17737163

申请日：2022-05-05

Applicant: Puridify Ltd.

Inventor： Michael Williams ,  Iwan Roberts ,  Oliver Hardick ,  Matthew Townsend ,  Christopher Morris ,  Shameer Subratty

IPC: G01N30/38 ,  G01N30/60

CPC classification number: G01N30/38 ,  G01N30/6017 ,  G01N2030/386 ,  G01N30/6017 ,  G01N2030/386

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

公开(公告)号：US11353433B2

公开(公告)日：2022-06-07

申请号：US16327985

申请日：2017-08-25

Applicant: Puridify Ltd.

Inventor： Michael Williams ,  Iwan Roberts ,  Oliver Hardick ,  Matthew Townsend ,  Christopher Morris ,  Shameer Subratty

IPC: G01N30/38 ,  G01N30/60 ,  G01N30/84

Abstract: A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.