公开(公告)号：US11885820B2

公开(公告)日：2024-01-30

申请号：US17408298

申请日：2021-08-20

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Brett Holmquist ,  Nigel J. Clarke ,  Richard E Reitz

IPC: G01N33/82 ,  G01N30/72 ,  G01N30/88 ,  H01J49/00

CPC classification number: G01N33/82 ,  G01N30/7233 ,  G01N30/88 ,  G01N2030/8813 ,  H01J49/0031 ,  H01J49/0045 ,  Y10T436/203332 ,  Y10T436/24

Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.

公开(公告)号：US20230375575A1

公开(公告)日：2023-11-23

申请号：US18364356

申请日：2023-08-02

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N33/68 ,  H01J49/00

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/0027 ,  Y10T436/212 ,  H01J49/00 ,  G01N2560/00

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US10429398B2

公开(公告)日：2019-10-01

申请号：US15489551

申请日：2017-04-17

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Brett Holmquist ,  Nigel J. Clarke ,  Richard E Reitz

IPC: G01N33/82 ,  G01N30/88 ,  G01N30/72 ,  H01J49/00

Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.

公开(公告)号：US20160139157A1

公开(公告)日：2016-05-19

申请号：US15005801

申请日：2016-01-25

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel J. Clarke ,  Brett Holmquist ,  Gloria Kwang-Ja Lee ,  Richard E. Reitz

IPC: G01N33/82

CPC classification number: G01N33/82 ,  G01N30/72 ,  G01N30/7233 ,  G01N2030/8813 ,  G01N2030/8822 ,  G01N2458/15 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/004 ,  Y10T436/20 ,  Y10T436/203332 ,  Y10T436/24

Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.

公开(公告)号：US11280799B2

公开(公告)日：2022-03-22

申请号：US17001425

申请日：2020-08-24

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N30/72 ,  H01J49/00 ,  H01J49/14 ,  G01N30/00 ,  G01N30/88 ,  G01N30/02

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

公开(公告)号：US20200158688A1

公开(公告)日：2020-05-21

申请号：US16748234

申请日：2020-01-21

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Brett Holmquist ,  Nigel Clarke ,  Anne Caston-Balderrama ,  Richard E. Reitz

IPC: G01N27/62 ,  G01N33/82

Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.

公开(公告)号：US10267810B2

公开(公告)日：2019-04-23

申请号：US15848325

申请日：2017-12-20

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel J. Clarke ,  Brett Holmquist ,  Gloria Kwang-Ja Lee ,  Richard E. Reitz

IPC: G01N33/82 ,  G01N30/72 ,  G01N30/88 ,  H01J49/00 ,  H01L49/00

Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.

公开(公告)号：US09535077B2

公开(公告)日：2017-01-03

申请号：US14063956

申请日：2013-10-25

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Brett Holmquist ,  Nigel J. Clarke ,  Richard E Reitz

IPC: G01N24/00 ,  G01N33/82 ,  G01N30/72 ,  G01N30/88

CPC classification number: G01N33/82 ,  G01N30/7233 ,  G01N30/88 ,  G01N2030/8813 ,  H01J49/0031 ,  H01J49/0045 ,  Y10T436/203332 ,  Y10T436/24

Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.

Abstract translation: 本发明涉及维生素D代谢物的检测。 在一个特定方面，本发明涉及通过质谱法检测衍生的维生素D代谢物的方法。

公开(公告)号：US09506937B2

公开(公告)日：2016-11-29

申请号：US14715153

申请日：2015-05-18

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  H01J49/00 ,  G01N33/68

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/0027 ,  Y10T436/212

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US20140051176A1

公开(公告)日：2014-02-20

申请号：US14063956

申请日：2013-10-25

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Brett Holmquist ,  Nigel J. Clarke ,  Richard E Reitz

IPC: G01N33/82

CPC classification number: G01N33/82 ,  G01N30/7233 ,  G01N30/88 ,  G01N2030/8813 ,  H01J49/0031 ,  H01J49/0045 ,  Y10T436/203332 ,  Y10T436/24

Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.

Abstract translation: 本发明涉及维生素D代谢物的检测。 在一个特定方面，本发明涉及通过质谱法检测衍生的维生素D代谢物的方法。