公开(公告)号：US20180209998A1

公开(公告)日：2018-07-26

申请号：US15928595

申请日：2018-03-22

Applicant: Randox Laboratories Limited

Inventor： Elouard Benchikh ,  Peter Fitzgerald ,  Ivan McConnell ,  Philip Lowry

IPC: G01N33/94 ,  C07K16/44

CPC classification number: G01N33/94 ,  C07K16/44 ,  C07K2317/33 ,  G01N33/946 ,  G01N2430/00

Abstract: Immunoassay methods and their requisite components for the detection and determination of phenethylamines of the 2C and DO sub-families are described.

公开(公告)号：US09945877B2

公开(公告)日：2018-04-17

申请号：US14451964

申请日：2014-08-05

Applicant: Randox Laboratories Limited

Inventor： Elouard Benchikh ,  Peter Fitzgerald ,  Ivan McConnell ,  Philip Lowry

IPC: G01N33/94 ,  C07K16/44

CPC classification number: G01N33/94 ,  C07K16/44 ,  C07K2317/33 ,  G01N33/946 ,  G01N2430/00

Abstract: Immunoassay methods and their requisite components for the detection and determination of phenethylamines of the 2C and DO sub-families are described.

公开(公告)号：US20170176476A1

公开(公告)日：2017-06-22

申请号：US15385063

申请日：2016-12-20

Applicant: Randox Laboratories Limited

Inventor： Ivan McConnell ,  Elouard Benchikh ,  Philip Lowry ,  Peter Fitzgerald

IPC: G01N33/94 ,  C07K16/44 ,  G01N33/543

CPC classification number: G01N33/9486 ,  C07K16/44 ,  C07K2317/33 ,  G01N33/54366

Abstract: An immunoassay method is described which detects O-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of O-desmethyltramadol and mitragynine.

公开(公告)号：US09671415B2

公开(公告)日：2017-06-06

申请号：US14874047

申请日：2015-10-02

Applicant: RANDOX LABORATORIES LIMITED

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  Philip Lowry ,  Elouard Benchikh

IPC: G01N33/94 ,  C07K16/44

CPC classification number: G01N33/94 ,  C07K16/44 ,  C07K2317/33 ,  G01N33/946

Abstract: The current invention provides an improved immunoassay for the detection and determination of pyrrolidinophenone based designer drugs in hair and biological fluids (urine, blood, and oral fluid). The generic immunoassay is underpinned by novel, sub-family-specific antibodies, which display surprising sensitivity. The invention further describes substrates comprising an antibody that is specific to compounds of the pyrrolidinophenone family. Also described are the novel immunogens from which the antibodies are derived and kits incorporating the antibodies of the current invention.

公开(公告)号：US20160266153A1

公开(公告)日：2016-09-15

申请号：US15067979

申请日：2016-03-11

Applicant: Randox Laboratories Limited

Inventor： Elouard Benchikh ,  Ivan McConnell ,  Peter Fitzgerald ,  Philip Lowry

IPC: G01N33/94 ,  C07K1/107 ,  C07K16/44 ,  C07K14/765 ,  C07K14/435

CPC classification number: G01N33/9426 ,  C07K1/1077 ,  C07K14/43504 ,  C07K14/765 ,  C07K16/44

Abstract: Antibodies, immunoassay methods and kits thereof are described for the detection and determination of 3-(aminomethyl)-5-methylhexanoic acid. The novel immunogens from which said antibodies are generated are also described.

Abstract translation: 描述了用于检测和测定3-（氨基甲基）-5-甲基己酸的抗体，免疫测定方法和试剂盒。 还描述了产生所述抗体的新型免疫原。

公开(公告)号：US10416175B2

公开(公告)日：2019-09-17

申请号：US15385063

申请日：2016-12-20

Applicant: Randox Laboratories Limited

Inventor： Ivan McConnell ,  Elouard Benchikh ,  Philip Lowry ,  Peter Fitzgerald

IPC: G01N33/94 ,  C07K16/44 ,  G01N33/543

Abstract: An immunoassay method is described which detects O-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of O-desmethyltramadol and mitragynine.

公开(公告)号：US10253006B2

公开(公告)日：2019-04-09

申请号：US15130137

申请日：2016-04-15

Applicant: RANDOX LABORATORIES LIMITED

Inventor： Elouard Benchikh ,  Ivan McConnell ,  Philip Lowry ,  Peter Fitzgerald

IPC: C07D295/155 ,  G01N33/53 ,  C07K14/47 ,  C07K14/765 ,  C07K16/44 ,  C07D295/096 ,  C07D241/04

Abstract: The current invention describes novel immunogens which are used in the production of novel antibodies with unique binding properties in that they cross-react with a variety of phenylpiperazine derivatives. These antibodies enable methods and kits to detect and/or determine phenylpiperazine derivatives (for example mCPP, TFMPP and MeOPP) in an in vitro sample which are advantageous over currently available analytical methods in terms of cost, ease of use, speed and sensitivity.

公开(公告)号：US20160084859A1

公开(公告)日：2016-03-24

申请号：US14859948

申请日：2015-09-21

Applicant: Randox Laboratories Limited

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  Phillip Lowry ,  Elouard Benchikh

IPC: G01N33/94 ,  C07K16/44 ,  C07D409/12 ,  C07D231/56

CPC classification number: G01N33/948 ,  C07D231/56 ,  C07D409/12 ,  C07K16/44

Abstract: Components for enabling immunodection of indazole synthetic cannabinoids are described including immunogens, haptens, antibodies, methods and kits.

Abstract translation: 描述了用于实现吲唑合成大麻素的免疫测定的组分，包括免疫原，半抗原，抗体，方法和试剂盒。

公开(公告)号：US20150346227A1

公开(公告)日：2015-12-03

申请号：US14723609

申请日：2015-05-28

Applicant: Randox Laboratories Limited

Inventor： Ivan McConnell ,  Elouard Benchikh ,  Philip Lowry ,  Peter Fitzgerald

IPC: G01N33/94 ,  A61K47/48 ,  A61K39/385

CPC classification number: G01N33/948 ,  A61K39/385 ,  C07D231/56 ,  C07K16/44 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/92

Abstract: An immunoassay method for detecting and determining adamantane substituted indazole and indole synthetic cannabinoids is described. Also described are components for use in implementing the method, namely, antibodies, detection agents, solid state devices and kits as well as immunogens used to raise the antibodies.

Abstract translation: 描述了用于检测和测定金刚烷取代的吲唑和吲哚合成大麻素的免疫测定方法。 还描述了用于实施该方法的组分，即抗体，检测剂，固态装置和试剂盒以及用于产生抗体的免疫原。

公开(公告)号：US20140242618A1

公开(公告)日：2014-08-28

申请号：US14186650

申请日：2014-02-21

Applicant: RANDOX LABORATORIES LIMITED

Inventor： Philip Lowry ,  Elouard Benchikh ,  Ivan McConnell ,  Peter Fitzgerald

IPC: G01N33/53

CPC classification number: G01N33/5308 ,  C07K16/44 ,  C07K2317/33

Abstract: The invention provides novel antibodies which specifically bind to the methylphenidate metabolite, ritalinic acid, enabling an immunoassay that can detect methyphenidate in biological samples for an extended period following its ingestion. The invention also describes novel conjugates and kits incorporating the antibodies.

Abstract translation: 本发明提供了特异性结合哌甲酯代谢物维拉酸的新型抗体，其能够进行生物样品中甲硝酸酯在其摄入后长时间内检测的免疫测定。 本发明还描述了掺入抗体的新型缀合物和试剂盒。