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公开(公告)号：US10596355B2
公开(公告)日：2020-03-24
申请号：US13173164
申请日：2011-06-30
Applicant: Ralph A. Chappa
Inventor： Ralph A. Chappa
IPC: A61M25/10
Abstract: A catheter assembly includes an expandable and collapsible structure having an outer surface. The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A coating is disposed on the outer surface of the expandable and collapsible structure. The coating includes a bioactive agent. A sleeve is disposed over the coating. The sleeve is adapted to expand between a compressed state and an enlarged state and to return to the compressed state. The sleeve defines a plurality of openings in the compressed state. An outer diameter of the coating is less than an outer diameter of the sleeve when the expandable and collapsible structure is in the contracted state and greater than the outer diameter of the sleeve when the expandable and collapsible structure is in the dilated state.
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公开(公告)号：US09295820B2
公开(公告)日：2016-03-29
申请号：US12583112
申请日：2009-08-14
Applicant: Ralph A. Chappa , Mark F. Carlson
Inventor： Ralph A. Chappa , Mark F. Carlson
CPC classification number: A61M25/1029 , A61M25/1018 , A61M25/1027 , A61M2025/1031 , A61M2025/105 , B05B13/0214 , B05B13/0228 , B05C13/00 , B05D1/002 , B05D1/02 , B05D3/12
Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
Abstract translation: 描述了一种用于涂覆球囊导管的球囊部分的涂覆装置。 涂覆装置包括可旋转构件，其中气囊导管的导管部分被安装和固定，并且引起气囊导管的旋转。 该装置还包括支撑构件，其中导管的远侧末端插入并自由旋转; 以及将喷射材料引导到气球表面上的喷嘴。 涂覆装置的本发明构造允许球囊导管沿着其轴线旋转，具有非实质或无摆动，这显着地改善了施加到气球表面的涂层的质量。
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公开(公告)号：US08961457B2
公开(公告)日：2015-02-24
申请号：US13248462
申请日：2011-09-29
Applicant: Ralph A. Chappa
Inventor： Ralph A. Chappa
CPC classification number: A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1081
Abstract: A catheter assembly includes an expandable and collapsible structure having an outer surface. The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A guard is bonded to the outer surface of the expandable and collapsible structure. The guard and the expandable and collapsible structure cooperatively define a plurality of reservoirs. A coating disposed in the reservoirs. The coating includes a bioactive agent. The coating protrudes from the reservoirs when the expandable and collapsible structure is expanded to the dilated state.
Abstract translation: 导管组件包括具有外表面的可膨胀和可折叠结构。 可膨胀和可折叠结构适于在收缩状态和膨胀状态之间膨胀。 防护件结合到可膨胀和可折叠结构的外表面。 护罩和可膨胀和可折叠结构协同地限定了多个储存器。 设置在储存器中的涂层。 涂层包括生物活性剂。 当可膨胀和可折叠结构膨胀到膨胀状态时，涂层从储存器突出。
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公开(公告)号：US08927000B2
公开(公告)日：2015-01-06
申请号：US13173143
申请日：2011-06-30
Applicant: Ralph A. Chappa , Emily R. Rolfes Meyering
Inventor： Ralph A. Chappa , Emily R. Rolfes Meyering
CPC classification number: A61L29/085 , A61L29/044 , A61L29/14 , A61L29/145 , A61L29/16 , A61M2025/105 , C08L91/00
Abstract: The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent.
Abstract translation: 本发明涉及用于从包括可扩张和可折叠结构的医疗装置输送治疗剂的组合物和使用它们的方法。 包括一种或多种脂肪酸的脂质涂层增加了在递送部位从装置释放的治疗剂的量。 治疗剂可以是包括亲水性聚合物或两亲性聚合物的基质。 释放和粘附涂层也可以促进治疗剂的递送。
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公开(公告)号：US08697106B2
公开(公告)日：2014-04-15
申请号：US13242837
申请日：2011-09-23
Applicant: Tim M. Kloke , Steven J. Keough , Nathan Lockwood , Margaret R. Gardner , Robert W. Hergenrother , Ralph A. Chappa
Inventor： Tim M. Kloke , Steven J. Keough , Nathan Lockwood , Margaret R. Gardner , Robert W. Hergenrother , Ralph A. Chappa
CPC classification number: A61L31/16 , A61L17/005 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/406 , A61L2300/62
Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
Abstract translation: 公开了一种包含由不可吸收缝合材料连接的多个珠粒的伤口间隔器。 该装置可以例如由受伤个体的第一响应者应用，或者可以由诸如2级医疗单位的创伤治疗设施应用。 在典型的实施方案中，该装置允许抗微生物剂如妥布霉素的位点特异性受控洗脱，包括在一段时间内如48或72小时的定义的洗脱。
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Patent Agency Ranking
公开(公告)号：US08668667B2
公开(公告)日：2014-03-11
申请号：US13339926
申请日：2011-12-29
Applicant: Ralph A. Chappa
Inventor： Ralph A. Chappa
IPC: A61M29/00
CPC classification number: A61M25/1011 , A61L29/085 , A61L29/16 , A61L2300/00 , A61M2025/1013 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
Abstract: The present invention relates to a catheter assembly that can deliver a therapeutic composition. The catheter assembly can include an outer balloon with openings for releasing the therapeutic composition. When the catheter assembly is in its contracted state, the openings are closed, and the assembly retains the therapeutic composition. When the catheter assembly is in its dilated state, the openings are open, and the therapeutic composition is released. The present invention also includes methods of making and using such a catheter assembly.
Abstract translation: 本发明涉及可递送治疗组合物的导管组件。 导管组件可以包括具有释放治疗组合物的开口的外球囊。 当导管组件处于其收缩状态时，开口关闭，并且组件保持治疗组合物。 当导管组件处于其扩张状态时，开口是开放的，并且治疗组合物被释放。 本发明还包括制造和使用这种导管组件的方法。
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公开(公告)号：US08318263B2
公开(公告)日：2012-11-27
申请号：US12980920
申请日：2010-12-29
Applicant: Mark F. Carlson , Steven J. Porter , Sean M. Stucke , Ralph A. Chappa
Inventor： Mark F. Carlson , Steven J. Porter , Sean M. Stucke , Ralph A. Chappa
CPC classification number: B05C3/109 , B05C9/14 , B05D1/18 , B05D3/061 , B05D2258/02
Abstract: Described herein is a method for coating an object with a polymer layer. The method includes contacting the object with a first solution comprising a non-polymeric grafting initiator comprising at least one photoinitiator group capable of generating a free radical active species upon absorption of electromagnetic energy, wherein the photoinitiator group is selected from the group consisting of an initiator that is insoluble in polar solvent; and a negatively charged initiator; irradiating the first solution and the object, resulting in the grafting initiator binding to the object; removing the first solution; contacting the object with a second solution comprising a polymerizable monomer having at least one free-radical polymerizable group; and irradiating the second solution and the object, wherein the non-polymeric grafting initiator acts as a photoinitiator for a free-radical polymerization reaction.
Abstract translation: 本文描述了用聚合物层涂覆物体的方法。 该方法包括使物体与第一溶液接触，所述第一溶液包含非吸收引发剂，所述非聚合接枝引发剂包含至少一种能够在吸收电磁能时产生自由基活性物质的光引发剂基团，其中所述光引发剂基团选自引发剂 不溶于极性溶剂; 和带负电的引发剂; 照射第一溶液和物体，导致接枝引发剂与物体结合; 去除第一个解决方案; 使物体与包含具有至少一个自由基可聚合基团的可聚合单体的第二溶液接触; 并照射第二溶液和物体，其中非聚合接枝引发剂用作自由基聚合反应的光引发剂。
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公开(公告)号：US20120165786A1
公开(公告)日：2012-06-28
申请号：US13173143
申请日：2011-06-30
Applicant: Ralph A. Chappa , Emily R. Rolfes Meyering
Inventor： Ralph A. Chappa , Emily R. Rolfes Meyering
CPC classification number: A61L29/085 , A61L29/044 , A61L29/14 , A61L29/145 , A61L29/16 , A61M2025/105 , C08L91/00
Abstract: The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent.
Abstract translation: 本发明涉及用于从包括可扩张和可折叠结构的医疗装置输送治疗剂的组合物和使用它们的方法。 包括一种或多种脂肪酸的脂质涂层增加了在递送部位从装置释放的治疗剂的量。 治疗剂可以是包括亲水性聚合物或两亲性聚合物的基质。 释放和粘附涂层也可以促进治疗剂的递送。
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公开(公告)号：US08166909B2
公开(公告)日：2012-05-01
申请号：US11559817
申请日：2006-11-14
Applicant: Ralph A. Chappa
Inventor： Ralph A. Chappa
IPC: B05B7/06
CPC classification number: B05B17/06 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/606 , A61L2420/02 , B05B1/26 , B05B7/0408 , B05B7/0416 , B05B7/0846 , B05B13/0228 , B05B17/0623 , B05D1/002 , B05D1/02 , B05D1/34 , B05D3/042
Abstract: The invention relates to systems and methods for forming coatings that can elute active agents and coating produced by the same. In an embodiment, the invention includes an apparatus for applying a coating to a medical device including a first spray nozzle, a first coating composition supply conduit, a second spray nozzle, and a second coating composition supply conduit. In an embodiment, the invention includes a method of applying a coating to a medical device including forming a first spray stream, forming a second spray stream, and directing the spray streams toward the medical device so that the first spray stream intersects the second spray stream before hitting the medical device. In an embodiment, the invention includes an apparatus for applying a coating to a medical device including a spray nozzle, a first coating composition supply conduit and a second coating composition supply conduit. In an embodiment, the invention includes a method of applying a coating to a medical device including applying a first composition onto the surface of a spray nozzle, applying a second composition onto the surface of the spray nozzle, generating a spray stream comprising the first composition and the second composition with the nozzle and directing the spray stream at the medical device.
Abstract translation: 本发明涉及用于形成可洗脱活性剂的涂层的系统和方法以及由其制备的涂层。 在一个实施方案中，本发明包括用于将涂层施加到包括第一喷雾喷嘴，第一涂料组合物供应导管，第二喷嘴和第二涂料组合物供应导管的医疗装置的装置。 在一个实施方案中，本发明包括将涂层施加到医疗装置的方法，包括形成第一喷雾流，形成第二喷雾流，并将喷雾流引向医疗装置，使得第一喷雾流与第二喷雾流相交 在击中医疗器械之前。 在一个实施例中，本发明包括一种用于将涂层施加到包括喷嘴，第一涂料组合物供应导管和第二涂料组合物供应导管的医疗装置的装置。 在一个实施方案中，本发明包括将涂层施加到医疗装置的方法，包括将第一组合物施加到喷嘴的表面上，将第二组合物施加到喷嘴的表面上，产生包含第一组合物的喷雾流 和具有喷嘴的第二组合物并将喷雾流引导到医疗装置。
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公开(公告)号：US08034369B2
公开(公告)日：2011-10-11
申请号：US11225301
申请日：2005-09-12
Applicant: Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
Inventor： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
IPC: A61F2/00
CPC classification number: A61K31/58 , A61F2310/00353 , A61K9/0051
Abstract: The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.
Abstract translation: 本发明提供一种用于治疗眼睛的控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分 身体构件偏离延伸方向，以及与本体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。 第一聚合物和第二聚合物是疏水性的，并且本体构件具有这样的长度，使得当将该装置放置在眼睛后部的植入部位时，该装置不进入眼睛的中心视野。 本发明还提供了将生物活性剂递送到眼后部区域的方法。
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